Puis-je prendre Lansoprazole et Clopidogrel ensemble ?

It is generally not recommended to take lansoprazole et clopidogrel together as lansoprazole can reduce how well clopidogrel works, making it less effective at preventing blood clots.

Clopidogrel needs to be changed into its active form by an enzyme in the liver (called CYP2C19) to work properly. Lansoprazole can interfere with this enzyme, meaning less of the clopidogrel is converted into its active 'blood-thinning' form.

You should speak to your doctor or pharmacist before taking these together. They may suggest an alternative stomach acid medicine, such as pantoprazole ou famotidine, which are less likely to interfere with clopidogrel.

Comment savoir si vous avez une interaction médicamenteuse

You may be experiencing an interaction between lansoprazole and clopidogrel if you notice:

• Douleur ou pression à la poitrine.

• Essoufflement.

• Weakness, numbness, or trouble speaking.

• Unexplained blood clots or stroke-like symptoms.

• Changes in bleeding patterns (less than expected).

If you notice these symptoms:

• Call emergency services immediately for chest pain, shortness of breath, or stroke-like signs.

• Do not stop your medications on your own.

• Contact your doctor as soon as possible.

• Keep a record of your symptoms and medications.

Drug Interaction

Lansoprazole can make clopidogrel less effective, increasing your risk of a heart attack or stroke. Your doctor may suggest a different stomach medicine, such as famotidine, instead.

Bleeding Risk

You must tell any surgeon or dentist that you are taking clopidogrel before any procedure is planned, as it increases the risk of serious bleeding and may need to be stopped 7 days in advance.

Diarrhée sévère

Le lansoprazole peut augmenter votre risque d'infections intestinales graves. Si vous développez une diarrhée aqueuse sévère ou persistante, ou de la fièvre, contactez immédiatement votre médecin et ne prenez pas de médicament anti-diarrhéique.

Lupus (LES) ou réactions cutanées

Contactez votre médecin si vous développez une éruption cutanée, surtout dans les zones exposées au soleil, car le lansoprazole peut provoquer une réaction cutanée auto-immune rare mais grave.

Jus de pamplemousse

Avoid drinking large amounts of grapefruit juice. Grapefruit contains compounds that can reduce the effectiveness of clopidogrel, potentially making it less effective at preventing blood clots.

Alcool

While alcohol does not directly interact with lansoprazole, it is best to limit or avoid it. Alcohol can increase stomach acid production and irritate the digestive system, which may worsen the symptoms your medicine is trying to treat.

It is best to avoid or strictly limit alcohol while taking clopidogrel. Both alcohol and clopidogrel can irritate the stomach lining and increase the risk of internal bleeding, particularly in the stomach and intestines.

Caféine (café, thé, cola)

Caffeine can trigger or worsen symptoms of acid reflux and stomach ulcers. If you are taking lansoprazole for these conditions, reducing your caffeine intake may help the medicine work more effectively.

Alimentation (Timing)

Lansoprazole works best if you take it at least 30 minutes before food. Taking it with or after food can make it less effective at reducing stomach acid.

Taking multiple medicines? Our Vérificateur d'Interactions Médicamenteuses helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Avertissement

Ces informations sont fournies à des fins éducatives générales uniquement et ne doivent pas être considérées comme un substitut aux conseils médicaux professionnels. Consultez toujours votre médecin généraliste, votre pharmacien ou un autre professionnel de santé qualifié avant de prendre des décisions concernant vos médicaments. Les circonstances individuelles peuvent varier, et seul un professionnel de santé connaissant votre historique médical peut fournir des conseils personnalisés.