Pantoprazole pour réduire l'acidité gastrique
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSLast updated 4 juil. 2023
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Pantoprazole reduces the amount of acid produced in your stomach.
Swallow the tablet whole - do not chew or crush it before you swallow.
The most common side-effects are stomach upset and headache. These effects are generally mild and do not last long.
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About pantoprazole
Type de médicament | Proton pump inhibitor |
Utilisé pour | Healing or prevention of gastric or duodenal ulcers; gastro-oesophageal reflux disease; Helicobacter pylori infection; Zollinger-Ellison syndrome |
Disponible sous forme de | Tablets and injection |
Acid is produced naturally in your stomach to help you digest food and to kill bacteria. This acid is irritant so your body produces a natural mucous barrier which protects the lining of your stomach. In some people, this barrier can break down allowing the acid to damage the stomach, causing inflammation, des ulcères and other conditions. Other people can have a problem with the muscular band at the top of the stomach that keeps the stomach tightly closed. This may allow the acid to escape and irritate the oesophagus, causing heartburn. This is often referred to as 'reflux acide'.
Proton pump inhibitors such as pantoprazole stop cells in the lining of the stomach from producing too much acid. This helps to prevent ulcers from forming, or assists the healing process where damage has already occurred. By decreasing the amount of acid, they can also help to reduce the symptoms of acid reflux disease, such as heartburn. Pantoprazole is also given as one part of a treatment to get rid of Helicobacter pylori, a bacterium found in the stomach, which can cause ulcers.
Pantoprazole is available on prescription. You can also buy short courses of pantoprazole at a pharmacy for the treatment of reflux symptoms (such as heartburn) in adults.
Before taking pantoprazole
Retour au sommaireSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking pantoprazole it is important that your doctor or pharmacist knows:
Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.
If you have any of the following symptoms: difficulty swallowing, loss of blood, weight loss, or if you are being sick (vomiting).
Si vous avez des problèmes avec le fonctionnement de votre foie, ou avec le fonctionnement de vos reins.
Si vous avez déjà eu une réaction allergique à un médicament.
Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.
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How to take pantoprazole
Retour au sommaireBefore you start this treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about pantoprazole and will provide you with a full list of the side-effects which you may experience from taking it.
If you have been prescribed pantoprazole, take it exactly as your doctor tells you to. There are different strengths of tablets available so your doctor will tell you which is right for you. It is usually taken once a day. If you are taking it for either Helicobacter pylori eradication or for Zollinger-Ellison syndrome, it is likely you will be asked to take two doses a day. Your doctor will tell you which dose is right for you and the directions will also be on the label of the pack to remind you.
If you have bought pantoprazole for symptoms such as heartburn, take one tablet in the morning. You may need to take pantoprazole for a day or so to control your symptoms. If your symptoms do not improve within a few days, you should talk with your doctor about this.
Swallow the tablets with a drink of water. Do not chew, crush or break the tablet before you swallow. Pantoprazole can be taken before or after food, although taking it before food is preferable.
If you forget to take a dose at your usual time, you can take it when you remember (unless it is nearly time for your next dose, in which case leave out the missed dose). Do not take two doses together to make up for a forgotten dose.
Tirer le meilleur parti de votre traitement
Retour au sommaireTry to keep your regular appointments with your doctor. This is so your progress can be checked. If you are taking pantoprazole on a long-term basis your doctor will want to review your treatment at least once a year to make sure it is still right for you.
A typical course of treatment lasts for one or two weeks if you are taking pantoprazole for Helicobacter pylori eradication. It will last for one or two months if it is to allow an ulcer to heal. For all other reasons for taking pantoprazole, your treatment will last for as long as is necessary to control your symptoms.
Some foods may make your symptoms worse. Foods and drinks that have been suspected of this include peppermint, tomatoes, chocolate, spicy foods, hot drinks, coffee, and alcoholic drinks. If it seems that a food is aggravating your symptoms, try avoiding it for a while to see if your symptoms improve. Also, try avoiding eating large meals, as these can make your symptoms worse too.
If you are overweight, it puts extra pressure on your stomach and encourages the symptoms of acid reflux. Losing some weight and eating a healthy balanced diet may help you.
Smoking increases the amount of acid produced by the stomach and may make your symptoms worse. If you are a smoker, speak with your doctor or pharmacist about how to quit.
Recent studies suggest that there may be a slight increase in the risk of bone fractures when proton pump inhibitors like pantoprazole are taken for longer than a year. If this affects you, your doctor will check that you are taking enough vitamin D and calcium to reduce this risk.
If you buy any medicines 'over the counter', always check with a pharmacist that they are safe to take alongside your other medicines.
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Can pantoprazole cause problems?
Retour au sommaireAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with pantoprazole. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Pantoprazole side-effects (these affect fewer than 1 in 100 people) | Que puis-je faire si je ressens cela ? |
Stomach upset (such as feeling sick (nausea), stomach ache, or wind), tummy (abdominal) pain, being sick (vomiting) | Stick to simple meals - avoid rich or spicy foods. If symptoms are severe or do not go away, let your doctor know |
Diarrhée | Drink plenty of water. If it continues or becomes severe, let your doctor know |
Constipation | Essayez de manger un régime équilibré et de boire plusieurs verres d'eau chaque jour |
Maux de tête | Buvez beaucoup d'eau et demandez à votre pharmacien de vous recommander un antidouleur approprié. Si les maux de tête persistent, informez votre médecin |
Se sentir étourdi ou fatigué | Ne conduisez pas et n'utilisez pas d'outils ou de machines jusqu'à ce que vous vous sentiez mieux |
Dry mouth, itchy skin rash, sleeping problems | Si l'un d'eux devient gênant, informez-en votre médecin |
Important: long-term use of pantoprazole (for at least three months) may lead to low levels of magnesium in your blood. Initial signs this might be happening include feeling tired, dizzy or confused and an irregular heartbeat (palpitations). Let your doctor know if you think this applies to you.
Si vous ressentez d'autres symptômes que vous pensez être dus au médicament, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.
How to store pantoprazole
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Yellow Card website.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Lectures complémentaires et références
- Manufacturer's PIL, Pantoprazole 20 mg gastro-resistant Tablets; Takeda UK Ltd, The electronic Medicines Compendium. Dated April 2022.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Prochaine révision prévue : 3 juil. 2026
4 juil. 2023 | Dernière version

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