Can I take Metformin and Naproxen together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking naproxen and metformin together can increase the risk of a rare but serious condition called lactic acidosis. It can also put extra strain on your kidneys, which may lead to metformin building up in your body.
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Why this happens
Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that can reduce blood flow to the kidneys and affect how well they filter waste. Since metformin is removed from the body by the kidneys, any decrease in kidney function can cause metformin levels to rise, increasing the risk of side effects.
What you should do
Use this combination with caution. If you need to take naproxen, keep it to the lowest dose for the shortest time possible. Ensure you stay well-hydrated. Speak to your doctor if you have any existing kidney problems, or if you experience unusual muscle pain, trouble breathing, or feeling very weak and cold.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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