Can I take Tramadol and Venlafaxine together?

Why this happens

Both tramadol and venlafaxine increase the levels of serotonin in the brain. When used together, these effects add up, potentially leading to dangerously high levels. Additionally, both drugs can lower the 'seizure threshold', making it easier for the brain to experience a seizure.

What you should do

You should speak to your doctor before taking these medicines together. They may prefer to prescribe an alternative painkiller or antidepressant. If your doctor decides you must take both, they will monitor you closely. Seek immediate medical help if you experience high fever, shivering, severe muscle stiffness, or confusion.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Clause de non-responsabilité

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.