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Progestérone

Cyclogest, Utrogestan

Progesterone is a natural female sex hormone.

Follow carefully the directions your doctor gives to you about taking progesterone. It is prescribed for a selected number of days each month.

Any side-effects are usually mild, but may include feeling sick (nausea), weight gain, and headache.

En un coup d'œil

  • Progesterone is a female hormone used for various gynaecological problems, including infertility and HRT.

  • It comes in several forms like capsules, gels, pessaries, and injections, each for different uses.

  • Your doctor will explain why it has been prescribed for you.

  • Always follow your doctor's instructions for taking progesterone.

  • Common side-effects can include feeling sick, headaches, and irregular periods.

  • Tell your doctor about certain conditions or other medicines you are taking before starting progesterone.

  • If you have diabetes, you might need to check your blood sugar more often.

About progesterone

Type de médicament

A progestogen

Utilisé pour

A variety of gynaecological problems, including infertility, in early pregnancy, and as part of hormone replacement therapy (HRT)

Aussi appelé

Crinone® vaginal gel; Cyclogest® pessaries; Lubion® injection; Lutigest® vaginal tablets; Utrogestan® capsules and vaginal capsules

Disponible sous forme de

Capsules, vaginal gel, vaginal capsules, pessaries and injection

Progesterone is a naturally occurring female sex hormone which is essential for the function of the female reproductive system. It is produced in the ovaries during the second half of the menstrual cycle, and also by the placenta during pregnancy. The amount of progesterone a woman produces declines during the menopause.

You will have been prescribed progesterone to supplement your naturally produced progesterone for a reason which your doctor will have explained to you. It works by adjusting the balance of your body's own hormones.

Progesterone is available in a number of formulations that are the subject of this leaflet (gel, injection, capsules, and pessaries). Each formulation is prescribed for a different gynaecological reason.

Progesterone may also be included as an ingredient in a number of combination products used for a variety of medical reasons. These products are not covered by this leaflet and you should read the printed information provided by your doctor and the manufacturer.

Before taking progesterone

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking progesterone, it is important that your doctor knows:

  • Si vous êtes enceinte ou si vous allaitez.

  • If you have migraines, asthma, epilepsy or high blood pressure.

  • If you are having any vaginal bleeding other than your normal monthly period.

  • If you have ever had a blood clot in your legs or lungs.

  • Si vous avez une maladie cardiaque.

  • If you have had any problems with the way your liver or kidneys work.

  • If you have ever had depression.

  • Si vous avez trop de sucre dans le sang (diabète sucré).

  • Si vous avez un cancer.

  • If during a pregnancy you had problems such as severe itching, yellowing of your skin or of the whites of your eyes (jaundice), or a skin condition called pemphigoid gestationis.

  • Si vous avez un trouble sanguin héréditaire rare appelé porphyrie.

  • Si vous avez déjà eu une réaction allergique à un médicament.

  • Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.

How to take progesterone

  • Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The leaflet will give you more information about the brand of progesterone you have been given. It will also provide a full list of side-effects which you may experience.

  • Follow carefully the instructions your doctor has given you. Progesterone is usually only used on a number of specified days during a monthly cycle. This may range from 4 to 25 days of a month depending on the reason it has been prescribed for you. If you are unsure about what to do, check again with your doctor.

If you have been prescribed:

  • Utrogestan® capsules as HRT: these should be taken at bedtime, on an empty stomach. This means that you should not take them with or soon after eating food. Just take them on the days of the month your doctor has told you to. You will also be prescribed an oestrogen-containing HRT medicine to take throughout the month.

  • Utrogestan vaginal® capsules for fertility treatment: use the applicator and follow the manufacturer's instructions for inserting the capsule high into the vagina. Do not take the capsule by mouth, although if you do swallow it accidentally, it will not harm you. The capsules are usually prescribed during the first three months of pregnancy only.

  • Lutigest® vaginal tablets for fertility treatment: put one tablet into the end of the applicator and use it to insert the tablet into the vagina following the manufacturer's instructions. Push the plunger to release the tablet. The usual dose is one tablet inserted three times daily starting on the day of egg retrieval. You will need to continue using Lutigest® for 30 days if pregnancy is confirmed. Follow the instructions of your doctor.

  • Crinone® vaginal gel for fertility treatment: use one 'applicatorful' daily into the vagina. Just use it on the days of the month your doctor has told you to.

  • Cyclogest® pessaries for menstrual problems: use twice daily on the days of the month your doctor has told you to. Pessaries are generally designed to be inserted into the vagina, but Cyclogest® pessaries are also suitable to be inserted into the back passage, as a suppository. If you are unsure which is the correct way for you to use them, check again with your doctor.

  • Lubion® injection for fertility treatment: make sure you know how to use this injection. If you are unsure which days to use it, or how much to use, check again with your doctor or clinic.

Tirer le meilleur parti de votre traitement

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Also, remember to keep any routine appointments for breast screening and cervical smear tests.

  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are on progesterone.

  • If you have diabetes you may need to check your blood glucose more frequently, as progesterone can affect the levels of sugar in your blood. Your doctor will advise you about this.

  • It is best to avoid smoking and drinking too much alcohol while on progesterone. If you are a smoker and you would like advice on how to quit, speak with your doctor or pharmacist.

  • If you buy any medicines, check with a pharmacist that they are suitable to take with progesterone. This is because some herbal preparations (such as St John's wort) can interfere with the way it works.

Can progesterone cause problems?

Along with their useful effects, all medicines can cause unwanted side-effects although not everyone experiences them. The table below lists some of the most common ones associated with progesterone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve over the first few days of taking or using a new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Common progesterone side-effects

Que puis-je faire si je ressens cela ?

Sensation de malaise (nausée)

Mangez des repas simples (évitez les aliments riches ou épicés)

Maux de tête

Ask your pharmacist to recommend a suitable painkiller. If the headaches continue or are unusually severe, speak with your doctor as soon as possible

Irregular periods, breast tenderness, weight changes, feeling dizzy or sleepy, difficulty sleeping, changes in sexual desire, mood changes, skin rash, acne-like spots, changes in hair growth, swollen feet and ankles (due to fluid retention)

Parlez à votre médecin si l'un de ces symptômes devient gênant

Si vous ressentez d'autres symptômes que vous pensez être dus à ce médicament, parlez-en à votre médecin ou à votre pharmacien.

How to store progesterone

  • Gardez tous les médicaments hors de la portée et de la vue des enfants.

  • Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.

Informations importantes sur tous les médicaments

Informations importantes sur tous les médicaments

Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.

Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.

Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.

Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.

Signaler les effets secondaires d'un médicament ou d'un vaccin

Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.

vérificateur de symptômes

Vous n'êtes pas sûr de mélanger des médicaments ?

Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.

Questions fréquemment posées

Can I use Cyclogest and Utrogestan together for progesterone support?

Each formulation of progesterone (like Cyclogest pessaries and Utrogestan capsules/vaginal capsules) is typically prescribed for a specific gynaecological reason. While they both contain progesterone, your doctor will have prescribed a particular type for your individual needs. You should only use the specific formulation and dosage your doctor has prescribed and follow their instructions carefully. If you have questions about combining or switching formulations, you should check with your doctor.

Does progesterone therapy cause weight gain?

Weight changes are listed as a possible side-effect of progesterone. If you notice weight changes and find them troublesome, you should speak with your doctor for advice.

What is the role of progesterone in the body?

Progesterone is a natural female sex hormone crucial for the female reproductive system. It is produced by the ovaries during the second half of the menstrual cycle and by the placenta during pregnancy. Its levels decrease during menopause. When prescribed as medication, it supplements your body's natural progesterone to adjust your hormone balance for various gynaecological issues, including infertility, early pregnancy support, and as part of hormone replacement therapy (HRT).

Who should not take progesterone, or should use it with extra caution?

You should inform your doctor if you have certain conditions before taking progesterone, as it might not be suitable or may require extra care. These include if you are pregnant or breastfeeding, have migraines, asthma, epilepsy, high blood pressure, a history of blood clots, heart problems, liver or kidney issues, depression, diabetes, cancer, or if you experienced specific problems during a previous pregnancy like severe itching, jaundice, or pemphigoid gestationis. Also mention if you have porphyria or have had an allergic reaction to any medicine in the past.

Are there any specific lifestyle habits I should avoid while taking progesterone?

It is advisable to avoid smoking and excessive alcohol consumption while on progesterone. If you are a smoker and would like to quit, your doctor or pharmacist can offer advice. Additionally, if you purchase any over-the-counter medicines, including herbal remedies like St John's wort, it's important to check with a pharmacist to ensure they won't interfere with your progesterone treatment.

When should I take Utrogestan capsules if prescribed for HRT?

If you have been prescribed Utrogestan capsules for HRT, you should take them at bedtime on an empty stomach. This means you should not take them with or soon after eating food. You should only take them on the specific days of the month your doctor has instructed you to. You will also typically be prescribed an oestrogen-containing HRT medicine to take throughout the month.

Lectures complémentaires et références

À propos de l'auteurVoir la biographie complète

Image de l'auteur

Michael Stewart, MRPharmS

Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien

BPharm (Hons), MRPharmS

Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.

À propos du critique

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Sid Dajani

Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.

Historique de l'article

Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.

  • Prochaine révision prévue : 8 juil. 2027
  • 9 janv. 2023 | Dernière version

    Dernière mise à jour par

    Michael Stewart, MRPharmS

    Revu par

    Sid Dajani
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