Trétinoïne pour l'acné
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 9 juin 2024
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Apply tretinoin exactly as your doctor tells you to. You will be asked to apply it either once or twice a day.
Your skin may become more sensitive to sunlight than usual. Avoid strong sunlight and do not use sunbeds.
You should avoid getting pregnant. Ask your doctor about suitable contraception.
En un coup d'œil
Tretinoin is a topical retinoid medicine used to treat mild-to-moderate acne.
It works by unblocking pores and helping to reduce inflammation.
Do not use tretinoin if you are pregnant or trying to conceive.
Apply a thin layer to affected areas, usually once or twice daily, as directed by your doctor.
Your skin may become more sensitive to sunlight, so use sun protection.
It can take several weeks to see an improvement, and side-effects like skin irritation may occur.
About tretinoin
Type de médicament | A rub-on (topical) retinoid |
Utilisé pour | Mild-to-moderate acne |
Aussi appelé | Aknemycin® Plus (contains tretinoin with erythromycin); Treclin® (contains tretinoin with clindamycin) |
Disponible sous forme de | Solution and gel |
Acne is the common cause of spots. Most people with acne are aged between 12 and 25, but some older and younger people are affected too. Small sebaceous glands lie just under your skin surface and make an oil (sebum) that keeps your skin supple and smooth. Tiny pores on your skin allow the sebum to come on to the surface of your skin. In acne, some of these pores become blocked, causing small pimples, blackheads and whiteheads (comedones).
Applying tretinoin to the areas of your skin with acne will help to unblock pores and treat blackheads or whiteheads. It also has an effect on reducing inflammation. Two brands of rub-on tretinoin are currently available. Aknemycin® Plus solution also contains an antibacterial agent called erythromycin. Treclin® gel contains an antibacterial agent called clindamycin.
Before using tretinoin
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using tretinoin it is important that your doctor knows:
If you are pregnant, trying for a baby or breastfeeding. You must not use tretinoin if you could be pregnant.
If you have a skin problem other than acne, such as if you have eczema or rosacea.
If you or any close family members have ever had skin cancer.
If you are taking or using any other medicines. This includes any creams you are using which are available to buy without a prescription.
Si vous avez déjà eu une réaction allergique à un médicament.
How to use tretinoin
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about tretinoin and will provide you with a full list of the side-effects which you may experience from using it.
Apply tretinoin exactly as your doctor tells you to. It is best if you wash and gently dry the affected areas of your skin before you apply it. A general point is that you should apply it to all of the area where your spots occur and not just to each spot. It is usual to apply the solution (Aknemycin® Plus) once or twice a day. Treclin® gel is applied once daily at bedtime. You only need to apply a thin layer. Remember to wash your hands after you have finished applying the solution/gel.
If you have recently been using a preparation for your acne that causes your skin to peel, allow your skin to recover for a few days before you start using tretinoin.
Do not use tretinoin on any areas of your skin which are sunburnt or sore. Also, try to avoid getting it on the sensitive areas of your skin in or around your nostrils, your eyes and your mouth. Try not to let it build up in the folds or creases of your skin.
Tirer le meilleur parti de votre traitement
It is recommended that you use a mild soap and lukewarm water to wash with, as very hot or cold water can worsen acne. You cannot clean off blackheads. The black tip of a blackhead is actually a skin pigment and cannot be removed by cleaning or scrubbing.
If your skin becomes very dry, it may help to use a moisturising cream (preferably a fragrance-free and water-based cream). Do not use ointments or oil-rich creams, as these could clog your pores again.
You can use make-up and moisturisers, but do not apply them at the same time as you use tretinoin. Try to avoid any skin products which exfoliate or dry your skin.
Tretinoin can make your skin more sensitive to sunlight than usual. A sun protection cream can help if you are out in the sun on bright days, even if it is cloudy. Do not use sunbeds.
It is normal for tretinoin treatment to take several weeks before there is a noticeable improvement in your skin. The most common reason for treatment failure is stopping treatment too soon thinking it is not working. If there is no improvement despite having used it for eight weeks, speak with your doctor again as there are other treatments which could be more suited to your condition.
You should avoid getting pregnant while you are using tretinoin as there is a slight risk of harm to unborn babies. If necessary, discuss with your doctor which types of contraception are suitable for you and your partner.
Once your spots have cleared, acne commonly flares up again if you stop treatment. To prevent this, it is usual to carry on with a maintenance treatment after your spots have gone. Your doctor will recommend a suitable preparation for you to use. It is common to need maintenance treatment for a number of years to keep acne away.
Can tretinoin solution or gel cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with rub-on tretinoin preparations. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Tretinoin solution/gel side-effects | Que puis-je faire si je ressens cela ? |
Skin irritation, redness, burning, dry or peeling skin | Reduce how often you apply tretinoin for a few days to see if this settles. If it is severe or troublesome, speak with your doctor |
Important : Aknemycin® Plus is an alcohol-based product and is flammable. Do not light a cigarette or use a naked flame until the solution has completely dried on your skin.
If you experience any other symptoms which you think may be due to tretinoin, speak with your doctor or pharmacist for further advice.
How to store tretinoin
Gardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
Si vous achetez des médicaments, vérifiez toujours avec un pharmacien qu'ils sont sûrs à utiliser avec vos autres médicaments.
This preparation is for external use only. If you suspect that someone has swallowed some of it by accident, contact the accident and emergency department of your local hospital for advice.
Si vous subissez une opération ou un traitement dentaire, informez la personne effectuant le traitement des médicaments que vous utilisez.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
Does tretinoin help with closed comedones?
Yes, tretinoin helps to unblock pores, which treats blackheads and whiteheads (comedones).
Does treclin contain tretinoin?
Yes, Treclin® gel is one brand of rub-on tretinoin that is available. It also contains clindamycin, an antibacterial agent.
How long does it typically take to see an improvement in acne after starting tretinoin?
It is normal for tretinoin treatment to take several weeks before you notice an improvement in your skin. The most common reason for treatment failure is stopping too soon because you think it isn't working. If there's no improvement after eight weeks, you should speak with your doctor again.
Can I use other skincare products like make-up or moisturisers while using tretinoin?
Yes, you can use make-up and moisturisers, but you should not apply them at the same time as tretinoin. You should also try to avoid any skin products that exfoliate or dry your skin.
What should I do if my skin becomes very dry from using tretinoin?
If your skin becomes very dry, using a moisturising cream can help. It's best to choose a fragrance-free and water-based cream. Avoid using ointments or oil-rich creams, as these could clog your pores again.
Lectures complémentaires et références
- Manufacturer's PIL, Aknemycin® Plus 4.0% w/w and 0.025% w/w cutaneous solution; Almirall Ltd, The electronic Medicines Compendium. Dated April 2020.
- Manufacturer's PIL, Treclin® 1% /0.025% w/w gel; Mylan (Viatris), The electronic Medicines Compendium. Dated October 2019.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
À propos de l'auteurVoir la biographie complète

Michael Stewart, MRPharmS
Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien
BPharm (Hons), MRPharmS
Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.
À propos du critique

Sid Dajani
Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Article également disponible en Anglais, Allemand, Espagnol, Français, Italien, Portugais, Hindi, Hébreu, Arabe, and Suédois.
Next review due: 22 May 2027
9 juin 2024 | Dernière version

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