Can I take Ibuprofen lysine and Sertraline together?
Drug interaction guide
Originally published 24 Jan 2026
Répond aux besoins du patient lignes directrices éditoriales
- TéléchargerTélécharger
- Partager
- Langue
- Discussion
Taking ibuprofen and sertraline together increases your risk of internal bleeding, particularly in the stomach or gut. You may also bruise more easily.
Dans cet article :
Poursuivre la lecture ci-dessous
Why this happens
Sertraline (an SSRI) and ibuprofen (an NSAID) both affect how your blood clots. Sertraline reduces the amount of serotonin in your blood platelets, which they need to stick together, while ibuprofen directly interferes with the clotting process and can irritate the lining of the stomach. Together, they make it much harder for your body to stop small bleeds.
What you should do
Speak to your doctor before taking these together. They may suggest a different painkiller, such as paracetamol, or prescribe a medicine to protect your stomach. Seek medical help immediately if you notice signs of bleeding, such as black or tarry stools, vomiting blood (which may look like coffee grounds), or unexplained bruising.
Poursuivre la lecture ci-dessous
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Traitement et médicaments
Can I take Amytriptaline and Ramipril together?
Taking amitriptyline and ramipril together can cause your blood pressure to drop lower than intended. This is most common when you first start the medication or when your dose is increased. You may feel dizzy, lightheaded, or faint, especially when standing up quickly from a sitting or lying position.
Traitement et médicaments
Can I take Amytriptaline and Aspirin together?
Taking amitriptyline and aspirin together can increase your risk of bleeding, particularly in the stomach or gut. You may also find that you bruise more easily.
Poursuivre la lecture ci-dessous
Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
24 janvier 2026 | Publié à l'origine
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets liés à la santé.
Vous ne vous sentez pas bien ?
Évaluez gratuitement vos symptômes en ligne
Inscrivez-vous à la newsletter destinée aux patients
Votre dose hebdomadaire de conseils santé clairs et fiables, rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.