Early-onset glaucoma
Dernière mise à jour 4 Apr 2022
Respecte les directives éditoriales
- TéléchargerTélécharger
- Partager
- Language
- Discussion
- Version audio
- Ajouter aux sources préférées sur Google
Glaucoma is a group of eye disorders in which the optic nerves connecting the eyes and the brain are progressively damaged. This damage can lead to reduction in side (peripheral) vision and eventual blindness. Other signs and symptoms may include bulging eyes, excessive tearing, and abnormal sensitivity to light (photophobia). The term "early-onset glaucoma" may be used when the disorder appears before the age of 40.
Description
Glaucoma is a group of eye disorders in which the optic nerves connecting the eyes and the brain are progressively damaged. This damage can lead to reduction in side (peripheral) vision and eventual blindness. Other signs and symptoms may include bulging eyes, excessive tearing, and abnormal sensitivity to light (photophobia). The term "early-onset glaucoma" may be used when the disorder appears before the age of 40.
In most people with glaucoma, the damage to the optic nerves is caused by increased pressure within the eyes (intraocular pressure). Intraocular pressure depends on a balance between fluid entering and leaving the eyes.
Usually glaucoma develops in older adults, in whom the risk of developing the disorder may be affected by a variety of medical conditions including high blood pressure (hypertension) and diabetes mellitus, as well as family history. The risk of early-onset glaucoma depends mainly on heredity.
Structural abnormalities that impede fluid drainage in the eye increase ocular pressure. These abnormalities may be present at birth and usually become apparent during the first year of life. Such structural abnormalities may be part of a genetic disorder that affects many body systems, called a syndrome. If glaucoma appears before the age of 3 without other associated abnormalities, it is called primary congenital glaucoma.
Other individuals experience early onset of primary open-angle glaucoma, the most common adult form of glaucoma. If primary open-angle glaucoma develops during childhood or early adulthood, it is called juvenile open-angle glaucoma.
Inheritance patterns
The source lists the following possible inheritance patterns: Autosomal recessive; Autosomal dominant. More than one pattern can apply in different cases.
Related genes
Other names
Hereditary glaucoma
Related patient information and medicines
Patient information leaflet
Problèmes visuels
This leaflet describes most eye conditions which can affect vision, either temporarily or permanently. Generally speaking, the further towards the back of the eye that problems occur, the m... Shingles is known for causing a painful one-sided blistering rash on the body and, if this is on the face, it can affect the eye. In addition, there is a.
Patient information leaflet
Glaucome
Glaucome est an eye condition which causes damage to the optic nerve at the back of your eye et can affect your vision. Glaucoma There are different types of glaucoma. The type usually referred to just as 'glaucoma' is the most common type. Technically it is called by one of the following names: Chronic open-angle glaucoma (COAG). Chronic.
Patient information leaflet
Glaucome aigu par fermeture de l'angle
Glaucome aigu par fermeture de l'angle is a serious eye condition that occurs when the fluid pressure inside the eye rises quickly, leading to sudden, severe eye pain, a red eye and reduced or blurred vision. It is a medical emergency. What is acute angle-closure glaucoma. Acut... What is the life expectancy of a glaucoma patient. Acute glaucoma does not.
Patient information leaflet
Corps flottants, éclairs et halos
They are a common symptom, particularly in older people. They can sometimes be a sign of underlying eye conditions tel que glaucoma. What are eye floaters. The la plupart common and important cause of this is acute glaucoma. Glaucome is a condition where there is increased pressure in the eye. Acute glaucoma is a very painful condition which can ....
Patient information leaflet
Puis-je prendre du magnésium et de la solifénacine ensemble ?
If you notice your bladder symptoms are not being controlled as well as usual, or if you suffer from severe constipation, speak with your pharmacist or doctor. Important precautions Glaucoma Do not take this medicine if you have narrow-angle glaucoma, as it can increase the pressure in your eye and worsen the condition. Kidney disease If you have.
Patient information leaflet
Uvée
If steroid eye drops are used for long periods of time, they can lead to clouding of your lenses (cataracts) or to raised pressure in your eye (glaucoma). Treatment to relieve pain and discomfort Cycloplegic eye drops : these are eye drops that relieve pain by causing the pupil in your eye to widen (dilate) b... Managing inflammation early and.
Lectures complémentaires et références
- Early-onset glaucoma; MedlinePlus, National Library of Medicine.
- Abu-Amero KK, Edward DP. Primary Congenital Glaucoma - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY. 2004 Sep 30 [updated 2017 Aug 17]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1135/
- Bayat B, Yazdani S, Alavi A, Chiani M, Chitsazian F, Tusi BK, Suri F, Narooie-Nejhad M, Sanati MH, Elahi E. Contributions of MYOC and CYP1B1 mutations to JOAG. Mol Vis. 2008 Mar 13;14:508-17.
- Chavarria-Soley G, Sticht H, Aklillu E, Ingelman-Sundberg M, Pasutto F, Reis A, Rautenstrauss B. Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme. Hum Mutat. 2008 Sep;29(9):1147-53. doi: 10.1002/humu.20786.
- Chen Y, Jiang D, Yu L, Katz B, Zhang K, Wan B, Sun X. CYP1B1 and MYOC mutations in 116 Chinese patients with primary congenital glaucoma. Arch Ophthalmol. 2008 Oct;126(10):1443-7. doi: 10.1001/archopht.126.10.1443.
- Choudhary D, Jansson I, Sarfarazi M, Schenkman JB. Characterization of the biochemical and structural phenotypes of four CYP1B1 mutations observed in individuals with primary congenital glaucoma. Pharmacogenet Genomics. 2008 Aug;18(8):665-76. doi: 10.1097/FPC.0b013e3282ff5a36.
- Scelsi HF, Barlow BM, Saccuzzo EG, Lieberman RL. Common and rare myocilin variants: Predicting glaucoma pathogenicity based on genetics, clinical, and laboratory misfolding data. Hum Mutat. 2021 Aug;42(8):903-946. doi: 10.1002/humu.24238. Epub 2021 Jun 24.
- Selvan H, Gupta S, Wiggs JL, Gupta V. Juvenile-onset open-angle glaucoma - A clinical and genetic update. Surv Ophthalmol. 2022 Jul-Aug;67(4):1099-1117. doi: 10.1016/j.survophthal.2021.09.001. Epub 2021 Sep 16.
- Turalba AV, Chen TC. Clinical and genetic characteristics of primary juvenile-onset open-angle glaucoma (JOAG). Semin Ophthalmol. 2008 Jan-Feb;23(1):19-25. doi: 10.1080/08820530701745199.
- Vasiliou V, Gonzalez FJ. Role of CYP1B1 in glaucoma. Annu Rev Pharmacol Toxicol. 2008;48:333-58. doi: 10.1146/annurev.pharmtox.48.061807.154729.
Participez à la conversation
Partagez vos pensées ou expériences avec les autres dans notre communautés de patients.
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.
Inscrivez-vous à la newsletter Patient
Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.