RAB18, member RAS oncogene family
Dernière mise à jour 18 Aug 2020
Respecte les directives éditoriales
- TéléchargerTélécharger
- Partager
- Language
- Discussion
- Version audio
- Ajouter aux sources préférées sur Google
La RAB18 gene provides instructions for producing the RAB18 protein, which functions as a GTPase. Often referred to as molecular switches, GTPases can be turned on and off. They are turned on (active) when they are attached (bound) to a molecule called GTP and are turned off (inactive) when they are bound to another molecule called GDP. When active, RAB18 is involved in a process called vesicle trafficking, which moves proteins and other molecules within cells in sac-like structures called vesicles. RAB18 regulates the movement of substances between compartments in cells and the storage and release of fats (lipids) by structures called lipid droplets. The protein also appears to play a role in a process called autophagy, which helps clear unneeded materials from cells. RAB18 is important for the organisation of a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport.
Normal function
La RAB18 gene provides instructions for producing the RAB18 protein, which functions as a GTPase. Often referred to as molecular switches, GTPases can be turned on and off. They are turned on (active) when they are attached (bound) to a molecule called GTP and are turned off (inactive) when they are bound to another molecule called GDP. When active, RAB18 is involved in a process called vesicle trafficking, which moves proteins and other molecules within cells in sac-like structures called vesicles. RAB18 regulates the movement of substances between compartments in cells and the storage and release of fats (lipids) by structures called lipid droplets. The protein also appears to play a role in a process called autophagy, which helps clear unneeded materials from cells. RAB18 is important for the organisation of a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport.
Conditions referring to this gene or chromosome
Other names
RAB18 small GTPase
RAB18LI1
ras-related protein Rab-18 isoform 1
ras-related protein Rab-18 isoform 2
ras-related protein Rab-18 isoform 3
ras-related protein Rab-18 isoform 4
ras-related protein Rab-18 isoform 5
WARBM3
Related patient information and medicines
Patient information leaflet
Faits et facteurs de risque du cancer du sein
La plupart cases of breast cancer occur by chance. However, breast cancer does occur more often than usual in some families because of their genetic makeup. Some facts about breast cancer Breast cancer is one of the most common cancers in the world. Pour details of the factors used to assess le risk, see the website of the National Institute for Health.
Patient information leaflet
Polyarthrite rhumatoïde
Rheumatoid arthritis causes inflammation, pain, and swelling of joints. Treatments include disease-modifying medicines to suppress inflammation, which can prevent or delay the progression of the disease, and medication to ease pain. Polyarthrite rhumatoïde treatment Standards of care you should expect The National Institute for Health and Care.
Patient information leaflet
Rétinoblastome
Most commonly, it affects children aged under 2, including newborn babies. It is a tumour of the nerve layer of the retina, which... Even though rétinoblastome is a genetic disease, most of these cases occur in families who have never had a family member with retinoblastoma. Siblings of an affected child dans a family in which aucune other family.
Patient information leaflet
Cancer du sein chez les hommes
We think of breast cancer as a disease of women because it is usually women who are affected. However, breast cancer can develop occasionally in men too. Whatever your gender, it is very important to see a doctor as soon as possible if you develop a lump in your breast. What is cancer du sein. Cancer is a condition where cells multiply abnormally,.
Patient information leaflet
Éruptions virales
Many viral infections can cause a éruption cutanée in addition to other symptoms. Rashes are very common with viral infections, especially in young children. It is very important to make sure the rash is not part of a serious infection - eg, meningococcal infection which is a bacterial infection and can be associated with meningitis. What is a viral rash. The.
Patient information leaflet
Albinisme
Albinisme is a rare inherited (genetic) condition which reduces the amount of of melanin pigment in the skin, hair and/or eyes. People with albinism are often pale, with light-coloured irises. However, there are many types of albinism and people can be affected to different degrees. What is albinism. Albinism is an inherited condition that leads to.
Lectures complémentaires et références
- RAB18, member RAS oncogene family; MedlinePlus, National Library of Medicine.
- Bem D, Yoshimura S, Nunes-Bastos R, Bond FC, Kurian MA, Rahman F, Handley MT, Hadzhiev Y, Masood I, Straatman-Iwanowska AA, Cullinane AR, McNeill A, Pasha SS, Kirby GA, Foster K, Ahmed Z, Morton JE, Williams D, Graham JM, Dobyns WB, Burglen L, Ainsworth JR, Gissen P, Muller F, Maher ER, Barr FA, Aligianis IA. Loss-of-function mutations in RAB18 cause Warburg micro syndrome. Am J Hum Genet. 2011 Apr 8;88(4):499-507. doi: 10.1016/j.ajhg.2011.03.012.
- Feldmann A, Bekbulat F, Huesmann H, Ulbrich S, Tatzelt J, Behl C, Kern A. The RAB GTPase RAB18 modulates macroautophagy and proteostasis. Biochem Biophys Res Commun. 2017 May 6;486(3):738-743. doi: 10.1016/j.bbrc.2017.03.112. Epub 2017 Mar 22.
- Gerondopoulos A, Bastos RN, Yoshimura S, Anderson R, Carpanini S, Aligianis I, Handley MT, Barr FA. Rab18 and a Rab18 GEF complex are required for normal ER structure. J Cell Biol. 2014 Jun 9;205(5):707-20. doi: 10.1083/jcb.201403026. Epub 2014 Jun 2.
- Handley MT, Carpanini SM, Mali GR, Sidjanin DJ, Aligianis IA, Jackson IJ, FitzPatrick DR. Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation. Open Biol. 2015 Jun;5(6):150047. doi: 10.1098/rsob.150047.
Participez à la conversation
Partagez vos pensées ou expériences avec les autres dans notre communautés de patients.
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.
Inscrivez-vous à la newsletter Patient
Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.