retinitis pigmentosa GTPase regulator
Dernière mise à jour 8 mai 2023
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La RPGR gene provides instructions for making a protein that is essential for normal vision. Although the protein's function is not well understood, studies suggest that it plays an important role in cell structures called cilia. Cilia are microscopic, finger-like projections that stick out from the surface of many types of cells. They are involved in cell movement and many different chemical signaling pathways. Cilia are also necessary for the perception of sensory input, including hearing, smell, and vision.
Normal function
La RPGR gene provides instructions for making a protein that is essential for normal vision. Although the protein's function is not well understood, studies suggest that it plays an important role in cell structures called cilia. Cilia are microscopic, finger-like projections that stick out from the surface of many types of cells. They are involved in cell movement and many different chemical signaling pathways. Cilia are also necessary for the perception of sensory input, including hearing, smell, and vision.
Several different versions (isoforms) of the RPGR protein are produced from the RPGR gene. One version contains a segment known as the ORF15 exon. This version of the RPGR protein is active (expressed) predominantly in the retina, which is the light-sensitive tissue at the back of the eye. Specifically, the ORF15-containing isoform is found in the retina's specialized light receptor cells (photoreceptors). Researchers suspect that this isoform may help maintain photoreceptors by regulating the function of cilia. Other isoforms of the RPGR protein are expressed in other parts of the body, where they are probably also involved in cilia function.
Conditions referring to this gene or chromosome
Other names
COD1
CORDX1
CRD
PCDX
retinitis pigmentosa 15
retinitis pigmentosa 3 GTPase regulator
RP15
RP3
RPGR_HUMAN
X-linked retinitis pigmentosa GTPase regulator
XLRP3
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Patient information leaflet
Problèmes oculaires
Macular degeneration The macula is the small area of the retina at the back of your eye and respon... Retinitis pigmentosa Retinitis pigmentosa is the term for several inherited diseases with a gradual deterioration of le light-sensitive cells of le retina. Retinal dystrophy Retinal dystrophies are a group of inherited disorders which result in.
Patient information leaflet
Problèmes visuels
Chorioretinitis Chorioretinitis is infection or inflammation of the choroid and retina. The choroid is the pigmented, highly vascular layer of the globe of the eye, whose main function is to nourish the outer layers of the retina. Retinitis pigmentosa (RP) 'Retinitis pigmentosa' is the term for several inherited diseases which cause a gradual.
Patient information leaflet
Syndrome de Charles Bonnet
One patient described trying to fight off the images of wild animals by using an umbrella. Charles Bonnet syndrome causes The main cause of the symptoms of CBS is loss of vision. The loss of vision may be caused by retinitis pigmentosa, Stargardt's disease or any other accident or disease which can affect the eyesight. Researchers believe that.
Patient information leaflet
Uvée
Uvée is a general term describing inflammation of the part of the eye called the uveal tract. This consists of the iris, ciliary body and choroid - although uveitis can additionally involve other parts of the eye. What is uveitis. Uveitis is inflammation of the uveal tract. The choroid : the layer of tissue between your rétine and your sclera,.
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Erreur médicale
There are several different options for making complaints about care: Making an 'informal complaint' can be a good first step, as this often resolves the problem more quickly than the formal complaint process. (In Northern Ireland, pharmacists sont regulated by the Pharmaceutical Society of Northern Ireland). The Health and Care Professions ....
Patient information leaflet
Mastocytose et troubles des mastocytes
A mast cell is a type of white blood cell. Altogether, they occur in about 1 in 150,000 people. The most common type - urticaria pigmentosa (see section on symptoms, below) - is seen in 1 person in every 1,000 who attends a skin (dermatology) clinic. What are the symptoms of mast cell disorders. Cutaneous mastocytosis When larger than normal.
Lectures complémentaires et références
- retinitis pigmentosa GTPase regulator; MedlinePlus, National Library of Medicine.
- Bachmann-Gagescu R, Neuhauss SC. The photoreceptor cilium and its diseases. Curr Opin Genet Dev. 2019 Jun;56:22-33. doi: 10.1016/j.gde.2019.05.004. Epub 2019 Jun 28.
- Bujakowska KM, Liu Q, Pierce EA. Photoreceptor Cilia and Retinal Ciliopathies. Cold Spring Harb Perspect Biol. 2017 Oct 3;9(10):a028274. doi: 10.1101/cshperspect.a028274.
- Churchill JD, Bowne SJ, Sullivan LS, Lewis RA, Wheaton DK, Birch DG, Branham KE, Heckenlively JR, Daiger SP. Mutations in the X-linked retinitis pigmentosa genes RPGR and RP2 found in 8.5% of families with a provisional diagnosis of autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2013 Feb 19;54(2):1411-6. doi: 10.1167/iovs.12-11541.
- Fahim AT, Daiger SP, Weleber RG. Nonsyndromic Retinitis Pigmentosa Overview. 2000 Aug 4 [updated 2023 Apr 6]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1417/
- Foote KG, Wong JJ, Boehm AE, Bensinger E, Porco TC, Roorda A, Duncan JL. Comparing Cone Structure and Function in RHO- and RPGR-Associated Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2020 Apr 9;61(4):42. doi: 10.1167/iovs.61.4.42.
- Fry AM, Leaper MJ, Bayliss R. The primary cilium: guardian of organ development and homeostasis. Organogenesis. 2014 Jan 1;10(1):62-8. doi: 10.4161/org.28910. Epub 2014 Apr 17.
- Hwang S, Jeon S, Yoon JM, Woo SJ, Joo K, Choi YJ, Yoon CK, Kim M, Lee HJ, Byeon SH, Lee CS, Jeon J, Kim JY, Han J, Surl D, Sagong M, Jeong A, Park TK, Park HS, Kim M, Hong YJ, Jang JH, Jang MA, Kim SJ. Retinitis Pigmentosa GTPase Regulator-Associated X-Linked Retinitis Pigmentosa: Molecular Genetics and Clinical Characteristics. Am J Ophthalmol. 2025 Jun;274:171-183. doi: 10.1016/j.ajo.2025.03.001. Epub 2025 Mar 6.
- Iannaccone A, Breuer DK, Wang XF, Kuo SF, Normando EM, Filippova E, Baldi A, Hiriyanna S, MacDonald CB, Baldi F, Cosgrove D, Morton CC, Swaroop A, Jablonski MM. Clinical and immunohistochemical evidence for an X linked retinitis pigmentosa syndrome with recurrent infections and hearing loss in association with an RPGR mutation. J Med Genet. 2003 Nov;40(11):e118. doi: 10.1136/jmg.40.11.e118. No abstract available.
- Lyraki R, Megaw R, Hurd T. Disease mechanisms of X-linked retinitis pigmentosa due to RP2 and RPGR mutations. Biochem Soc Trans. 2016 Oct 15;44(5):1235-1244. doi: 10.1042/BST20160148.
- May-Simera H, Nagel-Wolfrum K, Wolfrum U. Cilia - The sensory antennae in the eye. Prog Retin Eye Res. 2017 Sep;60:144-180. doi: 10.1016/j.preteyeres.2017.05.001. Epub 2017 May 11.
- Moore A, Escudier E, Roger G, Tamalet A, Pelosse B, Marlin S, Clement A, Geremek M, Delaisi B, Bridoux AM, Coste A, Witt M, Duriez B, Amselem S. RPGR is mutated in patients with a complex X linked phenotype combining primary ciliary dyskinesia and retinitis pigmentosa. J Med Genet. 2006 Apr;43(4):326-33. doi: 10.1136/jmg.2005.034868. Epub 2005 Jul 31.
- Murga-Zamalloa C, Swaroop A, Khanna H. Multiprotein complexes of Retinitis Pigmentosa GTPase regulator (RPGR), a ciliary protein mutated in X-linked Retinitis Pigmentosa (XLRP). Adv Exp Med Biol. 2010;664:105-14. doi: 10.1007/978-1-4419-1399-9_13.
- Pelletier V, Jambou M, Delphin N, Zinovieva E, Stum M, Gigarel N, Dollfus H, Hamel C, Toutain A, Dufier JL, Roche O, Munnich A, Bonnefont JP, Kaplan J, Rozet JM. Comprehensive survey of mutations in RP2 and RPGR in patients affected with distinct retinal dystrophies: genotype-phenotype correlations and impact on genetic counseling. Hum Mutat. 2007 Jan;28(1):81-91. doi: 10.1002/humu.20417.
- Shu X, Black GC, Rice JM, Hart-Holden N, Jones A, O'Grady A, Ramsden S, Wright AF. RPGR mutation analysis and disease: an update. Hum Mutat. 2007 Apr;28(4):322-8. doi: 10.1002/humu.20461.
- Thiadens AA, Soerjoesing GG, Florijn RJ, Tjiam AG, den Hollander AI, van den Born LI, Riemslag FC, Bergen AA, Klaver CC. Clinical course of cone dystrophy caused by mutations in the RPGR gene. Graefes Arch Clin Exp Ophthalmol. 2011 Oct;249(10):1527-35. doi: 10.1007/s00417-011-1789-3. Epub 2011 Aug 25.
- Vervoort R, Lennon A, Bird AC, Tulloch B, Axton R, Miano MG, Meindl A, Meitinger T, Ciccodicola A, Wright AF. Mutational hot spot within a new RPGR exon in X-linked retinitis pigmentosa. Nat Genet. 2000 Aug;25(4):462-6. doi: 10.1038/78182.
- Yang Z, Peachey NS, Moshfeghi DM, Thirumalaichary S, Chorich L, Shugart YY, Fan K, Zhang K. Mutations in the RPGR gene cause X-linked cone dystrophy. Hum Mol Genet. 2002 Mar 1;11(5):605-11. doi: 10.1093/hmg/11.5.605.
- Zhang Q, Giacalone JC, Searby C, Stone EM, Tucker BA, Sheffield VC. Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1353-1360. doi: 10.1073/pnas.1817639116. Epub 2019 Jan 8.
- Zito I, Downes SM, Patel RJ, Cheetham ME, Ebenezer ND, Jenkins SA, Bhattacharya SS, Webster AR, Holder GE, Bird AC, Bamiou DE, Hardcastle AJ. RPGR mutation associated with retinitis pigmentosa, impaired hearing, and sinorespiratory infections. J Med Genet. 2003 Aug;40(8):609-15. doi: 10.1136/jmg.40.8.609. No abstract available.
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