sequestosome 1
Dernière mise à jour 20 nov. 2025
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The SQSTM1 gene provides instructions for making a protein called sequestosome-1. This protein helps regulate bone remodeling, a normal process in which old bone is broken down and replaced by new bone. Sequestosome-1 is involved in a chemical signaling pathway that promotes the formation and activity of bone cells called osteoclasts, which are specialized cells that break down bone tissue during bone remodeling.
Normal function
The SQSTM1 gene provides instructions for making a protein called sequestosome-1. This protein helps regulate bone remodeling, a normal process in which old bone is broken down and replaced by new bone. Sequestosome-1 is involved in a chemical signaling pathway that promotes the formation and activity of bone cells called osteoclasts, which are specialized cells that break down bone tissue during bone remodeling.
In addition to its role in bone remodeling, sequestosome-1 may have other functions, although these are less well-defined. Sequestosome-1 may be involved in recycling worn-out cell parts and unneeded proteins (autophagy), the self-destruction of cells when they are no longer needed (apoptosis), and the body's immune responses and inflammatory reactions.
Conditions referring to this gene or chromosome
Other names
A170
autophagy receptor p62
OSIL
p60
p62
p62B
PDB3
ubiquitin-binding protein p62
ZIP3
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Lectures complémentaires et références
- sequestosome 1; MedlinePlus, National Library of Medicine.
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- Rendina D, Falchetti A, Diacinti D, Bertoldo F, Merlotti D, Giannini S, Cianferotti L, Girasole G, Di Monaco M, Gonnelli S, Malavolta N, Minisola S, Vescini F, Rossini M, Frediani B, Chiodini I, Asciutti F, Gennari L. Diagnosis and treatment of Paget's disease of bone: position paper from the Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS). J Endocrinol Invest. 2024 Jun;47(6):1335-1360. doi: 10.1007/s40618-024-02318-1. Epub 2024 Mar 15.
- Salari M, Etemadifar M, Neshat Ghalibaf M, Azizi F, Davoodi M, Asadi S. Neurodegeneration, Ataxia, Dystonia, and Gaze Palsy (NADGP) Syndrome with Nocturnal Paroxysmal Head Tremor. Mov Disord Clin Pract. 2023 Apr 20;10(5):835-838. doi: 10.1002/mdc3.13697. eCollection 2023 May. No abstract available.
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