Can I take Amitriptyline and Ripinrole together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking amitriptyline and ropinirole together can increase the risk of side effects such as extreme sleepiness, dizziness, and confusion. It may also increase the risk of 'serotonin syndrome', a rare but serious condition, and can lead to a sudden drop in blood pressure when standing up.
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Why this happens
Both medications affect chemicals in the brain and have 'sedating' effects that add together. Amitriptyline can also interfere with how the liver processes ropinirole, potentially leading to higher levels of the drug in your system. Additionally, both drugs can lower blood pressure, increasing the risk of falls.
What you should do
Speak to your doctor before taking these together. If your doctor prescribes both, be very careful when performing tasks that require alertness, such as driving. Move slowly when standing up from a sitting or lying position. Seek medical help immediately if you experience high fever, muscle stiffness, or agitation.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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