Can I take Atorvastatin and Ezetimibe together?

Why this happens

Both medicines work in different ways to lower cholesterol (atorvastatin stops the liver from making it, while ezetimibe stops the gut from absorbing it). Because both drugs can independently affect muscle tissue, taking them together has an 'additive' effect, meaning the small risk associated with each drug is combined.

What you should do

It is generally safe to take these together if prescribed by your doctor. You should monitor yourself for any unexplained muscle pain, tenderness, or weakness, especially when you first start the treatment or if your dose is increased. If you notice these symptoms, or if your urine becomes dark in colour, contact your doctor immediately.

Important precautions

Pregnancy

You must not take these medicines if you are pregnant or planning to become pregnant, as they can cause serious harm to an unborn baby. Use effective contraception while taking these medicines.

Muscle disorders

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Food and drink warnings

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

While there is no direct 'chemical' interaction, both these medicines and alcohol can affect your liver. Drinking large amounts of alcohol regularly while taking these medicines can increase the risk of liver problems. It is best to stay within the recommended UK low-risk guidelines (no more than 14 units per week).

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.