Can I take Esomeprazole and Sertraline together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking esomeprazole and sertraline together may increase the amount of sertraline in your bloodstream. This could potentially lead to an increase in side effects from the sertraline, such as feeling sick (nausea), tremors, or feeling restless.
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Why this happens
Esomeprazole can slow down the liver's ability to break down sertraline (specifically by inhibiting an enzyme called CYP2C19). This causes the sertraline to stay in your body longer and reach higher levels than usual.
What you should do
You can take these medicines together, but you should be aware of any new or worsening side effects. If you notice increased jitteriness, sleep problems, or nausea, speak to your doctor. They may decide to adjust your dose of sertraline.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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