Puis-je prendre l'Esoméprazole et la Sertraline ensemble ?

It is generally considered safe to take ésoméprazole et sertraline together.

Esomeprazole however can slow down the liver's ability to break down sertraline (specifically by inhibiting an enzyme called CYP2C19). This causes the sertraline to stay in your body longer and reach higher levels than usual.

How to take esomeprazole and sertraline safely

You can take these medicines together, but you should be aware of any new or worsening side effects.

Speak to your doctor if you notice:

• Increased jitteriness.

• Sleep problems.

• Sensation de nausée.

They may decide to adjust your dose of sertraline.

Dépressions et troubles anxieux

Vous pourriez ressentir une augmentation des pensées suicidaires ou de l'envie de vous faire du mal lorsque vous commencez la sertraline ou que vous modifiez la dose. Cela est plus fréquent chez les jeunes adultes de moins de 25 ans. Contactez immédiatement votre médecin ou rendez-vous à l'hôpital si vous remarquez des changements dans votre humeur ou votre comportement.

Risque de saignement

Sertraline increases your risk of bleeding, especially in the stomach. Taking it with esomeprazole can sometimes mask the symptoms of a stomach ulcer, so you must report any black, tarry stools or vomit that looks like coffee grounds immediately.

Low sodium (hyponatraemia)

Both medicines can cause the salt levels in your blood to drop too low, which is more common in elderly patients. Seek medical help if you experience severe confusion, muscle weakness, or seizures.

Syndrome sérotoninergique

Do not take sertraline with other medicines that increase serotonin (such as St John’s Wort or certain painkillers). Seek urgent help if you develop high fever, agitation, shivering, or muscle twitching.

Severe diarrhoea (C. difficile) - esomeprazole

Seek medical help if you develop severe or persistent watery diarrhoea, as this medicine can increase the risk of a serious bowel infection.

Vitamin B12 deficiency and bone fractures - esomeprazole

Long-term use (over a year) can weaken bones and lead to low magnesium or B12 levels; your doctor should monitor these if you are on long-term treatment.

Severe kidney or liver disease

Your doctor may need to prescribe a lower dose, as your body will take longer to clear esomeprazole.

Magnesium deficiency

Taking esomeprazole for more than three months can cause your blood magnesium levels to drop significantly, leading to fatigue, muscle spasms, or dizziness.

Masking stomach cancer symptoms

Esomeprazole can hide the symptoms of stomach cancer. You must tell your doctor if you have unexplained weight loss, persistent vomiting, or difficulty swallowing before starting this medicine.

Alcool

It is best to avoid or strictly limit alcohol while taking sertraline. Combining alcohol with this medication can increase the risk of side effects like drowsiness, dizziness, and impaired coordination. Additionally, alcohol can worsen the symptoms of depression or anxiety that sertraline is being used to treat.

While alcohol does not directly interact with esomeprazole, it can increase stomach acid production and irritate the stomach lining, which may worsen the symptoms your medicine is intended to treat. It is best to limit alcohol intake.

Jus de pamplemousse

Évitez de boire de grandes quantités de jus de pamplemousse. Le pamplemousse contient des composés qui peuvent augmenter les niveaux de sertraline dans votre sang, ce qui peut augmenter le risque d'effets secondaires.

Caféine

Caffeine (found in coffee, tea, and some fizzy drinks) can trigger or worsen acid reflux and heartburn. This may make esomeprazole less effective at managing your symptoms.

La sertraline peut parfois provoquer de la nervosité ou des tremblements. Consommer de grandes quantités de caféine peut aggraver ces effets secondaires ou augmenter les sensations d'anxiété. Il est conseillé de surveiller votre consommation de caféine.

Taking multiple medicines? Our Vérificateur d'Interactions Médicamenteuses helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Avertissement

Ces informations sont fournies à des fins éducatives générales uniquement et ne doivent pas être considérées comme un substitut aux conseils médicaux professionnels. Consultez toujours votre médecin généraliste, votre pharmacien ou un autre professionnel de santé qualifié avant de prendre des décisions concernant vos médicaments. Les circonstances individuelles peuvent varier, et seul un professionnel de santé connaissant votre historique médical peut fournir des conseils personnalisés.