Esoméprazole pour réduire l'acidité gastrique
Emozul, Guardium, Nexium
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 4 juil. 2023
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Esomeprazole reduces the amount of acid produced in your stomach.
The most common side-effects are headache and stomach upset. These effects are generally mild and soon pass.
En un coup d'œil
Esomeprazole is a medicine known as a proton pump inhibitor.
It is used to reduce the amount of acid your stomach produces.
It treats conditions like stomach ulcers and acid reflux.
Take esomeprazole exactly as your doctor or pharmacist tells you.
Do not chew the tablets or capsules, as they have a special coating.
Common side effects include headache and stomach upset.
Long-term use can affect magnesium levels or increase bone fracture risk.
About esomeprazole
Type de médicament | Proton pump inhibitor |
Utilisé pour | Gastric ulcers; duodenal ulcers; gastro-oesophageal reflux disease; Helicobacter pylori infection; Zollinger-Ellison syndrome |
Aussi appelé | Emozul®; Guardium®; Nexium® Combination brand: Vimovo® (esomeprazole with naproxène) |
Disponible sous forme de | Tablets, capsules, sachets and injection |
Acid is produced naturally in your stomach to help you digest food and to kill germs (bacteria). This acid is irritant so your body produces a natural mucous barrier which protects the lining of your stomach. In people who take painkillers called anti-inflammatoires non stéroïdiens (AINS), this barrier can break down, allowing the acid to damage the stomach, causing inflammation, ulcers and other conditions. Other people can have a problem with the muscular band at the top of the stomach that keeps the stomach tightly closed. This may allow the acid to escape and irritate the oesophagus, causing heartburn. This is often referred to as 'reflux acide'.
Proton pump inhibitors such as esomeprazole stop cells in the lining of the stomach from producing too much acid. This helps to prevent ulcers from forming, or assists the healing process where damage has already occurred. By decreasing the amount of acid, they can also help to reduce the symptoms of acid reflux disease, such as heartburn.
Esomeprazole is available on prescription and can be bought from pharmacies and other retail outlets for the relief of reflux symptoms.
Esomeprazole is also used as one part of a treatment to get rid of Helicobacter pylori, a bacterium found in the stomach, which can cause ulcers.
Before taking esomeprazole
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking esomeprazole it is important that your doctor or pharmacist knows:
Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.
Si vous avez des problèmes avec le fonctionnement de votre foie, ou avec le fonctionnement de vos reins.
If you have any of the following symptoms: difficulty swallowing, loss of blood, weight loss, or if you are being sick (vomiting).
Si vous avez déjà eu une réaction allergique à un médicament.
Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.
How to take esomeprazole
Before you start this treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about esomeprazole and will provide you with a full list of the side-effects which you may experience from taking it.
Take esomeprazole exactly as your doctor tells you to. There are different strengths of tablets and capsules available so your doctor will tell you which is right for you. It is common to take just one dose a day, although if you are taking it for either Helicobacter pylori eradication or for Zollinger-Ellison syndrome, you will be asked to take two doses a day. Your doctor will tell you which dose is right for you and the directions will also be on the label of the pack to remind you.
It is important that you don't chew esomeprazole before you swallow. The tablets, capsules and granules (in the sachets) are all manufactured with a special coating which must not be crushed. If you have difficulties swallowing, you can stir the tablets into a glass of water to make swallowing easier. The capsules likewise can be opened up and the contents mixed into water to make swallowing easier. If you make up your doses in this way, make sure that you drink the mixture within 30 minutes of making it. If you have been given sachets, pour the contents of each sachet into 15 ml of water. Stir the liquid and then leave it to thicken for a minute or so before stirring it again. Then swallow the liquid, rinse out the glass with a little more water, and then swallow this water too.
You can take esomeprazole before or after food.
If you forget to take a dose at your usual time, you can take it when you remember (unless it is nearly time for your next dose, in which case leave out the missed dose). Do not take two doses together to make up for a forgotten dose.
Tirer le meilleur parti de votre traitement
Try to keep your regular appointments with your doctor. This is so your progress can be checked. If you are taking esomeprazole on a long-term basis your doctor will want to review your treatment at least once a year to make sure it is still right for you.
Some foods may make your symptoms worse. Foods and drinks that have been suspected of this include peppermint, tomatoes, chocolate, spicy foods, hot drinks, coffee, and alcoholic drinks. If it seems that a food is aggravating your symptoms, try avoiding it for a while to see if your symptoms improve. Also, try avoiding eating large meals, as these can make your symptoms worse too.
If you are overweight, it puts extra pressure on your stomach and encourages the symptoms of acid reflux. Losing some weight and eating a healthy balanced diet may help you.
Smoking increases the amount of acid produced by the stomach and may make your symptoms worse. If you are a smoker, speak with your doctor or pharmacist about how to quit.
Recent studies suggest that there may be a slight increase in the risk of bone fractures when proton pump inhibitors like esomeprazole are taken for longer than a year. If this affects you, your doctor will check that you are taking enough vitamin D and calcium to reduce this risk.
If you buy any medicines 'over the counter', always check with a pharmacist that they are safe to take alongside your other medicines.
Can esomeprazole cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with esomeprazole. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Commun esomeprazole side-effects (these affect fewer than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
Maux de tête | Buvez beaucoup d'eau et demandez à un pharmacien de vous recommander un antidouleur approprié. Si les maux de tête persistent, informez votre médecin |
Constipation | Essayez de manger un régime équilibré et de boire plusieurs verres d'eau chaque jour |
Diarrhée | Buvez beaucoup d'eau pour remplacer les fluides perdus |
Feeling sick (nausea) or being sick (vomiting), stomach ache, wind | Optez pour des repas simples - évitez les aliments riches ou épicés |
Important: long-term use of esomeprazole (for at least three months) may lead to low levels of magnesium in your blood. Initial signs this might be happening include feeling tired, dizzy or confused and an irregular heartbeat (palpitations). Let your doctor know if you think this applies to you
Si vous ressentez d'autres symptômes que vous pensez être dus au médicament, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.
How to store esomeprazole
Gardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
What should I do if I am pregnant or breastfeeding and considering taking esomeprazole?
If you are pregnant, trying for a baby, or breastfeeding, it's important to inform your doctor or pharmacist before starting esomeprazole. They need to know this information to determine if the medicine is suitable for you.
Are there any specific symptoms I should tell my doctor about before taking esomeprazole?
Yes, you should inform your doctor if you have difficulty swallowing, have experienced blood loss, unexplained weight loss, or if you are being sick (vomiting). These symptoms are important for your doctor to consider before prescribing esomeprazole.
What if I have trouble swallowing the tablets or capsules?
If you have difficulty swallowing, you can stir the tablets or the contents of opened capsules into a glass of water to make them easier to take. It's important to drink this mixture within 30 minutes of preparing it.
Can I take esomeprazole if I have liver or kidney problems?
If you have any problems with the way your liver or kidneys work, you must tell your doctor or pharmacist. They will need to assess if esomeprazole is appropriate for you given your condition.
What should I do if I forget a dose of esomeprazole?
If you miss a dose at your usual time, you can take it when you remember. However, if it's almost time for your next scheduled dose, skip the missed dose. Never take two doses together to make up for a forgotten one.
What are the signs of low magnesium levels from long-term esomeprazole use?
Long-term use (at least three months) of esomeprazole may lead to low blood magnesium. Initial signs of this include feeling tired, dizzy or confused, and having an irregular heartbeat (palpitations). If you experience these, you should inform your doctor.
Lectures complémentaires et références
- Manufacturer's PIL, Nexium® 20 mg, 40 mg Tablets; AstraZeneca UK Limited, The electronic Medicines Compendium. Dated December 2021.
- Manufacturer's PIL, Nexium® 10 mg gastro-resistant granules for oral suspension, sachet; AstraZeneca UK Limited, The electronic Medicines Compendium. Dated December 2021.
À propos de l'auteurVoir la biographie complète

Michael Stewart, MRPharmS
Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien
BPharm (Hons), MRPharmS
Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.
À propos du critique

Sid Dajani
Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Article également disponible en Anglais, Allemand, Espagnol, Français, Italien, Portugais, Hindi, Hébreu, Arabe, and Suédois.
Prochaine révision prévue : 3 janv. 2028
4 juil. 2023 | Dernière version

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