Can I take Gabapentin and Zapain together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking gabapentin and Zapain together can significantly increase the risk of severe drowsiness, dizziness, and breathing difficulties. Zapain contains codeine (an opioid) and paracetamol. When combined with gabapentin, the sedative effects of both drugs are multiplied. In serious cases, this can lead to shallow or slow breathing (respiratory depression), extreme sleepiness, or loss of consciousness.
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Why this happens
Both gabapentin and the codeine in Zapain act as central nervous system (CNS) depressants. This means they both slow down brain activity and the signals that control breathing and alertness. When used together, they have an 'additive effect', meaning their combined impact is much stronger than taking either drug alone.
What you should do
You must speak to your doctor before taking these medicines together. If your doctor prescribes both, they will likely start you on the lowest possible doses and monitor you closely. Do not drive or operate machinery until you know how this combination affects you. Seek urgent medical help if you experience extreme sleepiness, confusion, or difficulty breathing. Avoid alcohol entirely, as it will make these dangerous side effects much worse.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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