Can I take Ibuprofen and Omeprazol together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no harmful interaction between ibuprofen and omeprazole. In fact, doctors often prescribe these two medicines together because omeprazole helps protect the stomach from the side effects of ibuprofen.
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Why this happens
Ibuprofen is an anti-inflammatory (NSAID) that can irritate the stomach lining and increase the risk of ulcers. Omeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. By lowering stomach acid, omeprazole helps prevent the irritation and potential bleeding that ibuprofen can cause.
What you should do
It is safe to take these medicines together. If you have been prescribed both, follow your doctor's instructions. If you are taking them over-the-counter, ensure you do not exceed the recommended dose on the packaging. Always take ibuprofen with food to further protect your stomach.
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Important precautions
Asthme
Do not take this medicine if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.
Stomach ulcers or bleeding
Avoid this medicine if you have ever had a stomach ulcer or gastrointestinal bleeding, as it significantly increases the risk of serious internal bleeding.
Pregnancy (third trimester)
Do not take ibuprofen if you are more than 28 weeks pregnant, as it can cause serious heart and kidney problems in the unborn baby and complications during birth.
Food and drink warnings
Alcool
Drinking alcohol while taking ibuprofen can increase the risk of stomach irritation and bleeding. It is best to limit alcohol intake or avoid it if you have a history of stomach issues.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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