Can I take Levothyroxine and Venlafaxine krka together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no direct interaction between levothyroxine and venlafaxine. However, if your thyroid levels are not properly controlled, it can affect how well venlafaxine works for your mood. Additionally, both medications can occasionally affect your heart rate or rhythm, particularly if your levothyroxine dose is too high.
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Why this happens
Levothyroxine is a thyroid hormone replacement, and venlafaxine is an antidepressant (SNRI). They do not interfere with each other's absorption or metabolism in the liver. However, an overactive thyroid (or too much levothyroxine) can increase the risk of heart-related side effects (like a fast heartbeat) which venlafaxine can also cause. Furthermore, untreated hypothyroidism can make depression harder to treat with antidepressants.
What you should do
You can safely take these medicines together. Ensure you take your levothyroxine on an empty stomach, at least 30 to 60 minutes before breakfast or any other medications (including venlafaxine), to ensure it is absorbed properly. It is important to have regular blood tests to ensure your thyroid levels are stable, as this helps your antidepressant work more effectively. If you notice a very fast or irregular heartbeat, palpitations, or increased anxiety, mention this to your doctor.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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