Can I take Paracetamol adult and Sentraline together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known direct interaction between paracetamol and sertraline. It is generally considered safe to take these two medicines together at the recommended doses.
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Why this happens
Paracetamol and sertraline are processed by different pathways in the liver and do not interfere with how the other is absorbed, broken down, or removed from the body. They also work on different systems in the body and do not have overlapping side effects.
What you should do
You can take paracetamol while taking sertraline. Always follow the dosage instructions on the paracetamol packaging and do not exceed 4 grams (eight 500mg tablets) in a 24-hour period. If you find you need to take paracetamol every day for more than a few days, you should speak to your doctor or pharmacist.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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