Chloramphenicol for eye infections
Brolene, Golden Eye
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSLast updated 18 janv. 2024
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Use chloramphenicol eye drops every 2-4 hours to begin with, and then reduce the frequency to four times a day as your symptoms improve.
Use chloramphenicol eye ointment 3-4 times daily. Alternatively, if you are using chloramphenicol eye drops during the day, use the ointment once at bedtime.
If your vision becomes blurred for a short while after using chloramphenicol, do not drive and do not use tools until you can see clearly again.
Do not wear contact lenses during treatment and for 24 hours after your last dose.
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About chloramphenicol eye drops and ointment
Type de médicament | Une préparation oculaire antibactérienne |
Utilisé pour | Infections oculaires |
Aussi appelé | Brolene Antibiotic®; Clorogen®; Eykappo®; Golden Eye Antibiotic®; Minims® Chloramphenicol; Mollifye®; Optrex® Infected Eyes |
Disponible sous forme de | Eye drops, single-use eye drops, eye ointment |
Chloramphenicol eye drops and eye ointment are used to treat bacterial eye infections. Les infections oculaires sont une cause fréquente de conjonctivite. In conjunctivitis, your eye becomes inflamed, feels gritty, and may water more than usual. The white of your eye may look red, and your eyelids can become swollen and stuck together with a discharge when you wake up in the morning. Only one eye may be infected to begin with, but it often spreads to both eyes.
Most cases of infective conjunctivitis clear within a few days without treatment. For more severe infections, or for infections which do not clear on their own, an antibiotic eye drop or ointment such as chloramphenicol can be helpful.
Chloramphenicol works by helping to kill the bacteria which are causing the infection. It is available on prescription. You can also buy the drops and the ointment from a pharmacy, without a prescription, if it is for conjunctivitis in an adult or in a child over 2 years of age. Do not use chloramphenicol eye drops or ointment for a child under 2 years old, unless it has been prescribed by a doctor.
Before using chloramphenicol eye drops or eye ointment
Retour au sommaireTo make sure this is the right treatment for you, before you start using chloramphenicol for an eye infection it is important that your doctor or pharmacist knows:
If you have a problem in your bone marrow or you or anyone in your family have a history of blood disorders.
If you have ever had an allergic reaction to chloramphenicol or to any other eye product.
Si vous êtes enceinte ou si vous allaitez.
Si vous portez des lentilles de contact souples.
If you have raised pressure in your eye (glaucoma) or dry eye disease.
If you have had eye surgery or laser treatment within the previous six months.
If you suspect an eye injury or a foreign body in the eye.
If you are using any other eye drops or eye ointments.
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How to use chloramphenicol eye drops
Retour au sommaireLavez-vous les mains avant d'utiliser les gouttes.
Remove the cap from the bottle (or the tip of the unit if you are using a single-use unit).
Inclinez légèrement la tête en arrière et tirez la paupière inférieure de votre œil vers le bas pour former une poche.
Hold the bottle (or single-use unit) upside down near to your eye. Try not to touch your eye as you do this.
Appliquez suffisamment de pression pour libérer une goutte dans votre œil. N'utilisez une deuxième goutte que si la première n'est pas entrée dans votre œil.
Fermez votre œil pendant une minute ou deux, et appuyez doucement sur le côté de votre nez où le coin de votre œil rencontre votre nez. Cela aide à empêcher la goutte de s'écouler et la maintient dans votre œil.
Repeat the process in your other eye if both eyes are affected.
Replace the cap (or if you are using a single-use unit, throw the used unit away).
How to use chloramphenicol eye ointment
Retour au sommaireWash your hands before you use the ointment.
Remove the cap from the tube.
Inclinez légèrement la tête en arrière et tirez la paupière inférieure de votre œil vers le bas pour former une poche.
Hold the tube upside down near to your eye.
Apply enough pressure to the tube to release a thin line of ointment along the inside of the lower eyelid. Try not to touch your eye as you do this.
Close your eye for a moment or two, and then blink a few times to spread the ointment around the inside of your eye.
Repeat the process in your other eye if both eyes are affected.
When you have finished, remember to replace the cap on the tube to prevent the ointment from becoming contaminated.
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Tirer le meilleur parti de votre traitement
Retour au sommaireBefore you start treating your eyes, read the manufacturer's printed information leaflet supplied with the product. It will give you more information about using chloramphenicol and will provide you with a full list of any side-effects which you may experience. If your eyes have an obvious discharge or 'crust', it can help if you bathe them with cool clean water before you use the chloramphenicol.
At first, chloramphenicol drops should be used every two to four hours unless you have been told otherwise. (Just use the drops while you are awake - you do not need to wake yourself up during the night to put them in.) As the infection improves, you can reduce the frequency down to four times a day. If you have been given chloramphenicol eye ointment to use as well as the eye drops, apply the ointment at night only. If you have been given chloramphenicol eye ointment without any drops, use the ointment three or four times each day.
Try not to miss any doses, but if you do forget, just use the drops/ointment as soon as you remember. Do not 'double up' the number of drops or the amount of ointment you use to make up for forgetting.
When you first put the eye drops or eye ointment into your eye, they can cause blurred vision. This should quickly clear. Make sure you can see clearly before you drive or use machines or tools.
Veillez à éviter de propager l'infection d'un œil à l'autre, ainsi qu'aux autres membres de votre famille. Se laver les mains régulièrement (surtout après avoir touché vos yeux) et ne pas partager de serviettes ou d'oreillers aidera à prévenir la propagation de l'infection.
If the tip of the tube/bottle touches your eye(s) when putting the drops in, it is a good idea to squeeze out two or three drops straightaway on to some tissue and rinse the tip with salt water.
Use chloramphenicol for a maximum of five days unless a doctor has told you otherwise. If your eyes are no better after two days of treatment, make an appointment to see your doctor for advice as soon as possible. You must also contact a doctor if your eyes become painful, if light hurts your eyes, or if your vision is impaired.
Eye infections can cause your eyes to become more sensitive to sunlight than usual. Wearing sunglasses can help ease this.
If you normally wear contact lenses, you should wear glasses until your symptoms have completely gone. It is recommended that you wait for 24 hours after you last use chloramphenicol before you put your lenses in again.
Can chloramphenicol eye preparations cause problems?
Retour au sommaireChloramphenicol drops and ointment can occasionally cause mild eye irritation or stinging, but these usually soon pass and not everyone will experience them. If the irritation continues, or if you experience any other eye problems, please speak with your doctor or pharmacist for advice.
How to store chloramphenicol eye preparations
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Chloramphenicol eye drops (including single-use units) must be kept in a fridge (2°C to 8°C).
Chloramphenicol eye ointment should be stored in a cool, dry place, away from direct heat and light.
Throw away the bottle or tube of chloramphenicol after you have finished the five-day course of treatment, even if there is some left. Never keep opened bottles or tubes to use later.
Single-use units should be used as soon as the unit is opened. Do not store or re-use opened units for subsequent doses. This is because the units do not contain any preservative.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
Assurez-vous que la personne fournissant ce médicament soit informée de tout autre médicament que vous prenez ou utilisez. Cela inclut tous les médicaments que vous avez achetés, ainsi que les médicaments à base de plantes et homéopathiques.
Si vous subissez une opération ou un traitement dentaire, informez la personne effectuant le traitement des médicaments que vous utilisez.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Si vous soupçonnez que quelqu'un a pu avaler une partie de ce médicament, contactez votre service local des urgences pour obtenir des conseils.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
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Lectures complémentaires et références
- Manufacturer's PIL, Chloramphenicol 0.5% Eye Drops; FDC International Ltd, The electronic Medicines Compendium. Dated June 2021.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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About the author

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Prochaine révision prévue : 17 janv. 2027
18 janv. 2024 | Dernière version

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