Comprimés de co-phénotrope pour la diarrhée
Revu par des pairs Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 27 avr. 2023
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The usual dose for acute diarrhoea in an adult is four tablets to start with, followed by two tablets every six hours until the diarrhoea is controlled. Do not take more than 10 tablets in 24 hours.
When you have diarrhoea it is important that you have lots of water to drink to prevent you from becoming lacking in fluid in the body (dehydrated). Eat as normally as possible, as soon as you feel able.
If your symptoms continue for more than 48 hours, speak with a doctor for advice if you have not already done so.
Co-phenotrope must not be taken by children under 16 years of age unless prescribed by a doctor.
En un coup d'œil
Co-phenotrope is a medicine used to treat sudden-onset diarrhoea.
It works by slowing down your bowel activity, which helps firm up stools and reduce bowel movements.
You should drink plenty of fluids to prevent dehydration when you have diarrhoea.
Do not take more than 10 tablets in 24 hours.
Speak to a doctor if your symptoms continue for more than 48 hours, worsen, or if you pass blood.
About co-phenotrope
Type de médicament | An antimotility medicine |
Utilisé pour | Diarrhée |
Aussi appelé | Diphenoxylate hydrochloride with atropine sulfate |
Disponible sous forme de | Comprimés |
Co-phenotrope is used in acute diarrhoea (this is diarrhoea which starts suddenly and lasts less than two weeks). It contains two ingredients: diphenoxylate hydrochloride and atropine sulfate. It is the diphenoxylate hydrochloride which is the main ingredient.
The most common cause of acute diarrhoea is infection. Other causes include drinking lots of beer, as a side-effect from other medicines, and anxiety. In most cases the diarrhoea settles within a few days, although it may take longer in some people. The main treatment is to have lots to drink to prevent lack of fluid in the body (dehydration). Antidiarrhoeal medicines like co-phenotrope may not be necessary; however, if you wish to reduce the number of trips that you need to make to the toilet, it can be useful. Most people only need to take it for a few days.
Diphenoxylate works by slowing down the activity of your bowel. This reduces the speed at which the contents pass through, and so food remains in your intestines for longer. This allows more water to be absorbed back into your body and results in firmer stools that are passed less often.
Because co-phenotrope regulates the passage of food through the digestive system, the tablets are also prescribed to help people regulate their bowel activity following surgery on the intestines.
Before taking co-phenotrope
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking co-phenotrope it is important that your doctor or pharmacist knows:
Si vous êtes enceinte ou si vous allaitez.
Si vous avez des problèmes avec le fonctionnement de votre foie ou de vos reins.
Si vous avez des problèmes respiratoires, tels que l'asthme ou la maladie pulmonaire obstructive chronique (MPOC).
Si vous avez des problèmes de prostate ou des difficultés à uriner.
If you have been told you have low blood pressure.
Si vous avez des problèmes avec votre thyroïde ou vos glandes surrénales.
Si vous avez de l'épilepsie.
If you have a problem in your bile duct.
If you have a bowel obstruction or an inflammatory bowel problem.
Si vous avez une affection provoquant une faiblesse musculaire, appelée myasthénie grave.
If you have ever had a drug addiction.
Si vous avez déjà eu une réaction allergique à un médicament.
Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.
How to take co-phenotrope
Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The manufacturer's leaflet will give you more information about the tablets and a full list of the side-effects which you may experience from taking them.
Start by taking four tablets, and then take a further two tablets every six hours until the diarrhoea is controlled. Do not take more than 10 tablets in 24 hours.
Co-phenotrope should not be taken by a child under 16 years of age unless it is on the advice of a doctor. If your child has been prescribed co-phenotrope, check the label carefully to make sure you know what dose to give, as the dose will depend upon your child's age.
If you forget to take a dose, do not worry, just take a dose after the next time you pass some diarrhoea. Do not take two doses together to make up for a missed dose.
Tirer le meilleur parti de votre traitement
It is important that you have lots to drink to prevent you from becoming lacking in fluid in the body (dehydrated). Drinking plain water is ideal, but juice and/or soup are also suitable. Try to avoid drinks that contain a lot of sugar, such as cola or pop, as they can sometimes make diarrhoea worse.
Oral rehydration salts can be taken to help prevent dehydration and replace lost salts. These are especially recommended for children and for people who are frail or who have underlying health problems. You can buy these from a pharmacy.
Eat small, light meals as soon as you are able. Plain foods such as wholemeal bread and rice are good foods to try eating first.
If your symptoms continue for more than 48 hours, speak with a doctor or pharmacist for advice if you have not already done so.
If your symptoms get worse, or if you develop a high temperature, or if you pass blood in the diarrhoea, you should ask your doctor or pharmacist for advice as soon as possible.
If you buy any medicines check with a pharmacist that they are suitable to take with co-phenotrope. This is because the risk of side-effects can be increased when co-phenotrope tablets are taken with some other medicines.
Do not take more than the prescribed dose. If you suspect that someone has taken an overdose of this medicine, or that a child has taken it by accident, go to the accident and emergency department of your local hospital straightaway. Take the container with you, even if it is empty.
Can co-phenotrope cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with co-phenotrope. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Co-phenotrope side-effects | Que puis-je faire si je ressens cela ? |
Feeling tired, sleepy or dizzy | Si cela se produit, ne conduisez pas et n'utilisez pas d'outils ou de machines jusqu'à ce que vous vous sentiez mieux |
Maux de tête | Buvez beaucoup d'eau et demandez à votre pharmacien de vous recommander un antidouleur approprié. Si les maux de tête persistent, informez votre médecin |
Tummy (abdominal) discomfort, feeling sick (nausea) | Try taking the tablets after eating some food if you are not already doing so |
Constipation | Stop taking co-phenotrope |
Feeling confused or restless, mood changes, high temperature (fever), dry mouth, difficulty passing urine, feeling flushed | These should soon pass. If any become troublesome, stop taking co-phenotrope |
Si vous ressentez d'autres symptômes que vous pensez être dus au médicament, parlez-en à votre médecin ou à votre pharmacien.
How to store co-phenotrope
Gardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
Can co-phenotrope be used for chronic diarrhoea?
Co-phenotrope is specifically intended for acute diarrhoea, which starts suddenly and lasts less than two weeks. The article does not mention its use for chronic conditions.
Is it safe to drive after taking co-phenotrope?
Co-phenotrope can cause side-effects such as feeling tired, sleepy or dizzy. If you experience these effects, it is not safe to drive or operate machinery until you feel better.
What should I do if I notice blood in my diarrhoea symptoms while taking co-phenotrope?
If you develop a high temperature, or if you pass blood in your diarrhoea, you should seek advice from your doctor or pharmacist as soon as possible.
Can co-phenotrope interact with other medications I am taking?
Yes, the risk of side-effects can increase when co-phenotrope is taken with certain other medicines. It's important to check with a pharmacist about any other medicines you are taking, including those bought without a prescription, to ensure they are suitable to use alongside co-phenotrope.
How soon can I expect co-phenotrope to work to control my diarrhoea?
The article does not specify an exact timeframe for when co-phenotrope starts to work. It indicates that you should take tablets until the diarrhoea is controlled, implying it should reduce symptoms relatively quickly. Most people only need to take it for a few days.
What if my diarrhoea doesn't improve after taking co-phenotrope for a few days?
If your symptoms continue for more than 48 hours, or if they get worse, you should speak with a doctor or pharmacist for advice.
Lectures complémentaires et références
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
À propos de l'auteurVoir la biographie complète

Michael Stewart, MRPharmS
Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien
BPharm (Hons), MRPharmS
Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.
À propos du critique

Sid Dajani
Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Article également disponible en Anglais, Allemand, Espagnol, Français, Italien, Portugais, Hindi, Hébreu, Arabe, and Suédois.
Prochaine révision prévue : 26 oct. 2027
27 avr. 2023 | Dernière version

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