Cyclobenzaprine pour la douleur musculaire aiguë
Amrix, Fexmid
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 27 fév 2023
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Cyclobenzaprine is used to relive short-term muscle pain caused by 'overstretching' injuries. You should not need to take this medicine for more than two to three weeks.
This medicine is used in addition to rest and physiotherapy to relieve pain while you recover from the muscle injury.
Taking cyclobenzaprine may make you feel sleepy or dizzy. If this happens do not drive and do not use tools or machines.
Try not to drink any alcohol while taking cyclobenzaprine as this will increase the chance of you feeling sleepy.
En un coup d'œil
Cyclobenzaprine is a medicine used to relieve acute muscle pain caused by injuries like strains and sprains.
It helps reduce pain and discomfort, making movement easier.
It is taken in addition to rest and physiotherapy.
Common side effects include feeling sleepy and stomach upset.
Do not drive or use machines if you feel drowsy or dizzy.
Cyclobenzaprine is not available in the UK and Europe.
About cyclobenzaprine
Type de médicament | Skeletal muscle relaxant |
Utilisé pour | Relieving acute muscle pain caused by injuries such as strains and sprains |
Aussi appelé | Amrix®; Fexmid® |
Disponible sous forme de | Tablets, extended-release capsules |
A short-term (acute) injury to the muscles, or the tissues which connect them, is usually the result of overstretching during sport or physical exercise. The most common injuries are strains and sprains which result in pain, swelling and restricted movement.
A strain refers to a painful condition brought about by inflammation, overuse (or using in an unbalanced way), and overstretching or tearing of muscles, tendons or joints.
A sprain is an injury to the band (ligament) which connects two or more bones to a joint. A sprain is usually caused by the joint being forced suddenly outside its usual range of movement.
Cyclobenzaprine (not available in the UK and Europe) helps relieve the pain of muscle spasms caused by these types of injury. It works by relaxing the muscles, which reduces pain and discomfort and makes movement easier. Cyclobenzaprine is used in addition to rest and physiotherapy to help you recover from the injury.
Before taking cyclobenzaprine
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking cyclobenzaprine it is important that your physician or pharmacist knows:
Si vous êtes enceinte, essayez d'avoir un bébé, ou allaitez.
If you have had a heart attack or you have any other heart problems.
If you have epilepsy or have ever had a fit (seizure).
Si vous avez des problèmes de foie ou de reins.
If you have an overactive thyroid gland (hyperthyroidism).
If you have a condition which makes it difficult for you to pass urine (urinary retention).
If you have raised pressure in your eye (glaucoma).
If you are taking, or have recently stopped taking, a type of antidepressant medicine known as a monoamine-oxidase inhibitor (MAOI).
If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription as well as herbal and complementary medicines.
Si vous avez déjà eu une réaction allergique à un médicament.
How to take cyclobenzaprine
Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The leaflet will give you more information about cyclobenzaprine and a full list of side-effects which you may experience from taking it.
Take cyclobenzaprine exactly as your physician tells you to. Your dose will be on the label of the pack to remind you. The tablets are available in three different strengths: 5 mg, 7.5 mg and 10 mg. The usual dose is one 5 mg tablet taken three times daily. Extended-release capsules are available in two strengths: 15 mg and 30 mg. The usual dose is one 15 mg capsule taken once daily with food.
Your physician may decide to increase your dose depending on how well you respond to the medicine.
Swallow the tablets whole with a glass of water. Amrix® extended release capsules should be swallowed whole or can be opened and the contents sprinkled on to a spoonful of apple sauce. This should then be swallowed immediately without chewing. Rinse the mouth with water afterwards and safely dispose of the empty capsule.
Try to take your doses at the same times of day each day, as this will help you to remember to take them. If you do forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a forgotten dose.
Tirer le meilleur parti de votre traitement
Following a sprain or strain the usual advice is to pay the PRICE (Protection, Rest, Ice, Compression, and Elevation) and avoid HARM (Heat, Alcohol, Running, and Massage) for the first 48-72 hours after injury.
You should not play sport or do any vigorous exercise involving the damaged part while you are taking cyclobenzaprine.
Try to keep any appointments with your physician or physiotherapist. This is so they can check on your progress.
Cyclobenzaprine may cause drowsiness. It may also increase the time it takes for you to react, so it can impair your judgement. If this happens do not drive and do not use tools or machines.
It is recommended that you do not drink alcohol while you are taking cyclobenzaprine. This is because it increases the chance that you will experience side-effects such as feeling sleepy or dizzy.
With proper rest and care most sprains and strains heal within a few weeks. You should not need to continue taking cyclobenzaprine for longer than three weeks. If your injury is still causing pain after this time, make an appointment to see your physician or speak with a pharmacist.
Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.
Si vous achetez des médicaments, vérifiez avec un pharmacien qu'ils sont sûrs à prendre avec vos autres médicaments.
Can cyclobenzaprine cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with cyclobenzaprine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your physician or pharmacist if any of the following continue or become troublesome.
Common cyclobenzaprine side-effects | Que puis-je faire si je ressens cela ? |
Se sentir somnolent, fatigué ou étourdi | Si cela se produit, ne conduisez pas et n'utilisez pas d'outils ou de machines |
Tummy (abdominal) pain, nausea or vomiting, diarrhea | Drink plenty of water and stick to simple foods - avoid rich or spicy meals |
Maux de tête | Drink plenty of water. If the headaches continue, stop taking cyclobenzaprine |
Bouche sèche | Try chewing sugar-free gum or sucking sugar-free candy |
Sleeping difficulties, mood changes, confusion, fast heartbeat, needing to pass urine more often or difficulty passing urine, feeling shaky, increased sweating, and rash | If any of these become troublesome, discuss them with your physician |
Cyclobenzaprine can affect the levels of a chemical called serotonin in the brain. On rare occasions, medicines that raise the level of serotonin can cause it to go too high and cause problems. The risk is higher if you are taking more than one medicine with this effect. Other examples include selective serotonin reuptake inhibitor (SSRI) antidepressant medicines and opioid painkillers such as tramadol and morphine. Seek medical attention if you develop a combination of the following:
Muscles raides ou mouvements 'saccadés'.
Rythme cardiaque inhabituellement rapide.
High temperature (fever), nausea or vomiting, diarrhea.
Se sentir délirant ou voir des visions (halluciner).
If you experience any other symptoms which you think may be due to this medicine, speak with your physician or pharmacist.
How to store cyclobenzaprine
Gardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the emergency room of your local hospital. Take the container with you, even if it is empty.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne conservez pas de médicaments périmés ou indésirables. Demandez à votre pharmacien comment éliminer les médicaments en toute sécurité dans votre région.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
What is the primary difference between a muscle strain and a sprain?
A strain specifically refers to an injury involving muscles, tendons, or joints, often due to overuse, inflammation, or overstretching. A sprain, on the other hand, is an injury to a ligament, which is the band connecting two or more bones at a joint, typically caused by the joint being forced beyond its normal range of movement.
Why is cyclobenzaprine not available in the UK and Europe?
The article states that cyclobenzaprine is not available in the UK and Europe. It does not provide specific reasons for this unavailability.
Are there particular medications I should avoid while taking cyclobenzaprine?
Yes, you should inform your physician or pharmacist if you are taking, or have recently stopped taking, a type of antidepressant medicine called a monoamine-oxidase inhibitor (MAOI). Also, be aware that taking cyclobenzaprine with other medicines that affect serotonin levels, like certain antidepressant medicines (SSRIs) and opioid painkillers (such as tramadol and morphine), can increase the risk of serotonin syndrome. Always check with a pharmacist if you buy any other medicines to ensure they are safe to take with cyclobenzaprine.
How long should I expect to take cyclobenzaprine for a muscle injury?
With proper rest and care, most sprains and strains heal within a few weeks. You should not typically need to continue taking cyclobenzaprine for longer than three weeks. If your pain persists beyond this period, you should consult your physician or speak with a pharmacist.
What should I do if I forget a dose of cyclobenzaprine?
If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, you should skip the missed dose. Do not take two doses together to try and compensate for a forgotten one.
Lectures complémentaires et références
- Manufacturer's FDA label, Cyclobenzaprine Tablets 5mg, 10mg; Mylan Institutional Inc. DailyMed, National Institutes of Health, U.S National Library of Medicine. Dated December 2019.
- Manufacturer's FDA label, Amrix® extended release capsules; Cephalon, Inc. DailyMed, National Institutes of Health, U.S National Library of Medicine. Dated May 2020.
À propos de l'auteurVoir la biographie complète

Michael Stewart, MRPharmS
Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien
BPharm (Hons), MRPharmS
Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.
À propos du critique

Sid Dajani
Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Article également disponible en Anglais, Allemand, Espagnol, Français, Italien, Portugais, Hindi, Hébreu, Arabe, and Suédois.
Next review due: 26 Aug 2027
27 fév 2023 | Dernière version
1 Mar 2017 | Publié à l'origine
Écrit par :
Michael Stewart, MRPharmS

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