Déferiprone comprimés et solution orale

About deferiprone

Thalassaemia is an inherited (genetic) condition affecting the blood. Your red blood cells contain a protein called haemoglobin which carries oxygen around your body and gives your blood its red colour. In people with thalassaemia, part of the haemoglobin is faulty and does not work properly. If there is not enough normal haemoglobin in your blood, you become anaemic. As a consequence, your body tries to make more haemoglobin and more red blood cells, and goes into overproduction mode.

As a result of the combination of overproduction, a need for regular blood transfusions of normal red blood cells to treat the anaemia, and also because your condition makes your body absorb a lot of iron from food, you can become overloaded with iron. Deferiprone is a chelation treatment, which means that it helps your body to get rid of excess iron. It works by combining with the extra iron to form a complex which your body can remove. It will be prescribed for you if other (usually preferred) treatments are either unsuitable for you, or insufficient to control your symptoms.

Before taking deferiprone

Some medicines are not suitable for people with certain conditions and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking deferiprone it is important that your doctor knows:

• Si vous êtes enceinte, si vous essayez d'avoir un enfant ou si vous allaitez.

• Si vous avez des problèmes de fonctionnement du foie ou des reins.

• If you have been told you have a low number of white cells in your blood.

• Si vous prenez ou utilisez d'autres médicaments. Cela comprend tous les médicaments que vous prenez et qui sont disponibles sans ordonnance, ainsi que les médicaments à base de plantes et les médicaments complémentaires.

• Si vous avez déjà eu une réaction allergique à un médicament.

How to take deferiprone

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about deferiprone and will also provide you with a full list of side-effects which you could experience from taking it.

• Take deferiprone exactly as you are told to by your doctor. Your dose will depend upon how much you weigh, so your doctor will tell you how many tablets or how much medicine to take. The directions for taking the medicine will also be printed on the label of the pack to remind you about what the doctor said to you. You will be asked to take three doses every day. Take your first dose in the morning, your second dose around lunchtime and your third dose in the evening. You can take deferiprone either before or after meals.

• There are two different strengths of tablet available - 500 mg and 1 g. Your dose may include a combination of both strengths of tablet.

• Si vous oubliez de prendre une dose, prenez-la dès que vous vous en rendez compte. Essayez de prendre le nombre correct de doses chaque jour, mais ne prenez pas deux doses en même temps pour compenser une dose oubliée.

• Treatment with deferiprone is usually long-term, although your treatment may need to be interrupted if you develop an infection. Continue to take the tablets/medicine regularly unless your doctor tells you otherwise.

Tirer le meilleur parti de votre traitement

• Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. You will need to have regular weekly blood tests during treatment.

• Deferiprone may cause your urine to turn a red/brown colour. This is the iron being removed from your body and is nothing for you to worry about as it is quite harmless.

• If you need to take an indigestion remedy, choose one that does not contain aluminium. Your pharmacist will be able to give you advice about which antacids and other medicines are suitable for you to buy 'over the counter'.

• You must not become pregnant while you are taking deferiprone and for six months after stopping treatment. Please make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. Men should not father a child for at least three months after stopping treatment.

• If you are due to have an operation or any dental treatment, always tell the person carrying out the treatment which medicines you are taking.

Can deferiprone cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with deferiprone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Si vous ressentez d'autres symptômes que vous pensez être dus au médicament, veuillez consulter votre médecin ou votre pharmacien pour obtenir des conseils supplémentaires.

How to store deferiprone

• Conservez tous les médicaments hors de la portée et de la vue des enfants.

• Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.

• Once a bottle of liquid medicine has been opened, it will keep for 35 days. Please obtain a fresh supply after this time.

Informations importantes sur tous les médicaments