Procarbazine capsules

About procarbazine

Procarbazine is a medicine which is given to treat some cancers. It is given in particular to treat Maladie de Hodgkin. It can be prescribed alone, or it can be given in combination with other medicines. Hodgkin's disease, which is also called Hodgkin's lymphoma, is a cancer of the lymph glands. Lymph glands are part of the body's immune system.

In cancer, certain cells in the body grow and multiply too fast. Anti-cancer medicines like procarbazine work by slowing the growth of cancer cells.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking procarbazine it is important that your doctor knows:

• Si vous avez des problèmes avec le fonctionnement de votre foie, ou avec le fonctionnement de vos reins.

• Si vous avez une infection ou vous vous sentez particulièrement mal.

• Si vous avez une maladie cardiaque ou une maladie des vaisseaux sanguins.

• Si vous avez de l'épilepsie.

• Si vous êtes enceinte ou si vous allaitez.

• If you have a tumour on your adrenal glands which is causing high blood pressure (called phaeochromocytoma).

• Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.

• Si vous avez déjà eu une réaction allergique à un médicament.

• Before you start the treatment, read any printed information you have been given by your doctor and the printed manufacturer's leaflet from inside the pack of capsules. These will give you more information about procarbazine and will provide you with a full list of the side-effects which you may experience from taking it.

• Procarbazine will be prescribed for you by a specialist doctor who is experienced in treating your condition. The doctor will calculate what dose is right for you and will tell you how many capsules to take each day - it is important that you take procarbazine exactly as you are told to. Treatment for Hodgkin's disease is usually prescribed in cycles, with each cycle lasting about 4-6 weeks. You will be prescribed procarbazine for several days of each cycle, and your dose may increase during a cycle. The directions will be printed on the label of the pack of capsules, but if you are at all unsure about what to do, you should contact your doctor or hospital clinic for advice.

• If you forget to take a dose, take it as soon as you remember unless your next dose is due within a couple of hours (in this case, take the next dose when it is due but leave out the forgotten dose). Do not take two doses together to make up for a missed dose.

• You must try to keep your regular appointments with your doctor or hospital. This is so your doctor can check on your progress. You will need to have regular check-ups during treatment.

• Do not drink alcohol while you are on procarbazine. This is because the combination of procarbazine together with alcohol can cause an unpleasant reaction and make you feel very unwell. It can cause you to have a throbbing headache, a flushed face, and the sensation of a 'thumping' heart (palpitations), and make you feel very sick. Many liquid medicines and mouthwashes contain alcohol, so always read the contents on the label and avoid any product which contains alcohol.

• Certain foods and drinks can cause an unpleasant reaction with procarbazine. Try to avoid mature cheese, yeast or meat extracts (such as Marmite®, Oxo® and Bovril®), broad bean pods, pickled herring, salami sausage, pepperoni sausage, Bologna sausage, overripe fruit, non-alcoholic beers, lagers and wines and foods which have been fermented, pickled, smoked, 'hung' or matured. If you want to eat or drink anything on the list you could try a little at a time, until you are sure that it doesn't upset you.

• Procarbazine lowers the number of white cells in your blood and this increases the chance that you may get an infection. You should take precautions to reduce the risk of infection whenever you can. So, if possible, avoid other people with infections and let your doctor know straightaway if you think you are getting a sore throat or if you have a high temperature.

• While you are taking procarbazine, do not have any immunisations (vaccinations) without talking with your doctor first. Because procarbazine lowers your body's resistance, there is a chance that you may get an infection from some vaccines.

• If you buy or take any other medicines, check with a pharmacist that they are safe to take alongside procarbazine.

• Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.

• It is important that you do not get pregnant or father a child while you are taking procarbazine. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner.

• If you intend to have children in the future, you should ask your doctor for advice about family planning before you begin taking procarbazine. This is particularly important if you are a man, as there is a risk of reduced fertility after procarbazine treatment.

Along with their useful effects, most medicines can cause side-effects although not everyone experiences them. Before you start treatment with procarbazine your doctor will discuss with you the possibility of unwanted side-effects occurring. The table below contains some of the most common ones. You will find a full list of side-effects in the manufacturer's information leaflet supplied with your capsules.

• Gardez tous les médicaments hors de la portée et de la vue des enfants.

• Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.