Proguanil avec atovaquone pour la prévention du paludisme

About proguanil with atovaquone

Proguanil with atovaquone tablets are used to prevent paludisme. Malaria is a serious infection. It is common in tropical countries such as parts of Africa, Asia and South America. Malaria is a disease which is passed on to humans by infected mosquitoes. A parasite called plasmodium lives inside the stomachs of infected female mosquitoes and is passed on to humans by a bite.

Étant donné que le schéma du paludisme varie selon la région du monde où vous voyagez, ainsi que la saison et le type d'activité que vous avez prévu, vous devriez toujours obtenir les derniers conseils sur la prévention du paludisme auprès de votre médecin, pharmacien ou organisateur de voyage. Un voyage en sac à dos peut bien nécessiter des mesures préventives différentes contre le paludisme par rapport à celles nécessaires pour un voyage d'affaires dans une ville.

Proguanil with atovaquone is usually obtained on a prescription from a doctor; however, it is not prescribable on the NHS. This means that you will be given a private (non-NHS) prescription and you will be asked to pay for the tablets. Proguanil with atovaquone tablets (Maloff Protect®) can also be bought from a pharmacy without the need for a doctor's prescription. You will still be asked for details of your health and travel plans to ensure the medicines are suitable.

Proguanil with atovaquone can also be used to treat some forms of malaria if you become infected. This leaflet does not contain information about this, but your doctor can give you more information if you have been prescribed it for this reason.

Before taking proguanil with atovaquone

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking the tablets it is important that your doctor or pharmacist knows:

• Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.

• Si vous avez des problèmes rénaux.

• Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.

• Si vous avez déjà eu une réaction allergique à un médicament.

How to take proguanil with atovaquone

• Before you take proguanil with atovaquone, read the manufacturer's printed information leaflet from inside the pack. The leaflet will give you more information about the tablets and a full list of side-effects which you may experience from taking them.

• You should start taking the tablets 1 or 2 days before you enter the area which has malaria. This is to ensure there is sufficient medicine in your bloodstream to give you the required protection. Take one dose each day throughout your stay, and then continue to take one dose a day for a further seven days after you leave the area. There are two strengths of tablets: 250 mg/100 mg tablets which are suitable for adults and children weighing more than 40 kg, and 62.5 mg /25 mg tablets which are suitable for children weighing between 11 kg and 40 kg:
  

  • The dose for an adult or a child weighing over 40 kg is one 250 mg/100 mg tablet daily.

  • The dose for a child weighing 31-40 kg is three 62.5 mg/25 mg tablets daily.

  • The dose for a child weighing 21-31 kg is two 62.5 mg/25 mg tablets daily.

  • The dose for a child weighing 11-21 kg is one 62.5 mg/25 mg tablet daily.

• Where possible, take the tablets with a snack or a milky drink and try to take your doses at about the same time of day, each day. The tablets are best swallowed whole, but for children who have problems swallowing tablets, they can be crushed and mixed into soft food or a milky drink if needed. You should ensure the child consumes the entire mixture to get the full dose.

• If you are sick (vomit) less than one hour after taking the tablet(s) you should take another dose. If it happens more than one hour afterwards, the medicines will have already entered your bloodstream so another dose is not needed.

• If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose. You should complete the course of tablets unless you are told otherwise by a doctor. Make sure you continue to take the tablets for seven days after your visit has finished.

Tirer le meilleur parti de votre traitement

• Ces comprimés vous aideront à prévenir le paludisme, mais il est également important de prendre les précautions suivantes pour éviter les piqûres de moustiques :
  

  • Couvrez les zones découvertes de vos bras et jambes avec des vêtements amples à manches longues, des pantalons longs et des chaussettes. Cela est particulièrement important si vous êtes à l'extérieur après le coucher du soleil, car c'est à ce moment que les moustiques se nourrissent.

  • Use an effective insect repellent spray on your clothing and any area of your skin which is bare.

  • Vaporisez la pièce avec un insecticide chaque soir, quelques heures avant d'aller vous coucher. Vérifiez vos zones de couchage pour les moustiques - portez une attention particulière aux meubles et aux zones sous votre lit où les insectes peuvent se cacher.

  • Si vous dormez dans une pièce non protégée, utilisez une moustiquaire imprégnée d'insecticide.

• If you need to take a medicine for indigestion (such as an antacid), do not take it during the two hours before you take proguanil with atovaquone, or during the two hours after you take it. This is because some magnesium-containing antacids interfere with the way one of the medicines (proguanil) is absorbed by your body, making it less effective.

• If you take a medicine called warfarin to prevent blood clots you may need to have your warfarin dose adjusted. You should ask for an INR appointment to be arranged prior to travel and start taking proguanil with atovaquone at least two days before the appointment.

• If you feel ill or develop a fever or flu-like symptoms while you are travelling or within one year of returning home, you should see your doctor straightaway. This is important, even if you have taken your anti-malarial tablets correctly.

Can proguanil with atovaquone cause problems?

En plus de leurs effets bénéfiques, la plupart des médicaments peuvent provoquer des effets secondaires indésirables, bien que tout le monde ne les ressente pas. Ceux-ci s'améliorent généralement à mesure que votre corps s'adapte au nouveau médicament, mais parlez à votre médecin ou à votre pharmacien si l'un des effets secondaires suivants persiste ou devient gênant.

If you experience any other symptoms which you think may be due to this medicine, speak with a doctor or pharmacist.

How to store proguanil with atovaquone

• Gardez tous les médicaments hors de la portée et de la vue des enfants.

• Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.

Informations importantes sur tous les médicaments