Valproate de sodium pour l'épilepsie

About sodium valproate

Sodium valproate is prescribed to treat maladie épileptique et crises. Il peut être pris aussi bien par les adultes que par les enfants.

A seizure is a short episode of symptoms which is caused by a burst of abnormal electrical activity in the brain. Sodium valproate works by reducing these abnormal electrical activities.

There is also a medicine with a similar name but which is used to treat a different condition. See the medicine leaflet called Valproate de semisodium pour le trouble bipolaire pour plus d'informations à ce sujet.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking sodium valproate it is important that your doctor knows:

• Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.

• If you or a close member of your family have liver problems.

• Si vous avez des problèmes avec le fonctionnement de vos reins.

• If you have an inflammatory condition called systemic lupus erythematosus (also called lupus or SLE).

• Si vous avez un trouble sanguin héréditaire rare appelé porphyrie.

• If you have been told you have a mitochondrial disorder or a urea cycle disorder.

• Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.

• Si vous avez déjà eu une réaction allergique à un médicament.
  

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about sodium valproate and it will provide you with a full list of the side-effects which you may experience from taking it.

• Take sodium valproate exactly as your doctor tells you to. It is usual to start treatment on a low dose, and then for the dose to be increased gradually to a regular maintenance dose. Most people take one or two doses daily. Doses for children are tailored to their age and weight.

• Read the printed information with your supply for more details about how you should take your doses. For example, many brands of sodium valproate must be taken with or just after food. Some brands of tablets are crushable to make them easier to swallow. Others must be swallowed whole without crushing or chewing. The label on the pack and the printed information leaflet from inside will provide this sort of information for you. Alternatively, you can ask your pharmacist to advise you.

• If you have been prescribed sachets (granules), you can swallow the granules by pouring them into your mouth and swallowing them with a drink of water. If you prefer, you can sprinkle the granules on to some soft food (yoghurt or ice cream, for example) or into a cool drink. Do not chew the granules.

• Try to get into a habit of taking sodium valproate at the same time(s) each day. This will help you avoid missing doses.

• If you do forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a forgotten dose.

• Lorsque vous commencez un nouveau traitement pour l'épilepsie, il peut y avoir un changement dans le nombre ou le type de crises que vous ressentez. Votre médecin vous conseillera à ce sujet.

• Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. You will need to have blood tests before you start the medicine and while you are taking it.

• There are several brands of sodium valproate available and your treatment could be affected by switching between brands made by different manufacturers. Each time you collect a new supply from your pharmacy, check to see if it looks the same as you have had before. If it is different, please discuss this with your pharmacist who will advise you.

• You need to take sodium valproate every day. Stopping treatment suddenly can cause problems. If it becomes necessary for the treatment to stop, your doctor will want you to reduce your dose over a few days.

• Sodium valproate can harm an unborn child so you doivent avoid getting pregnant while you are taking sodium valproate. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. If you are a woman and want to have a family, discuss this with your doctor so that you can be given advice from a specialist about alternative treatment avant you become pregnant.

• Les personnes atteintes d'épilepsie doivent arrêter de conduire. Votre médecin vous conseillera sur le moment où il sera possible pour vous de recommencer à conduire. Cela sera généralement après une année sans crises.

• Pendant que vous êtes traité pour l'épilepsie, il existe un petit risque que vous développiez des changements d'humeur, des pensées perturbantes et des sentiments suicidaires. Si cela se produit, vous devez en informer votre médecin immédiatement.

• If you buy any medicines, always check with a pharmacist that they are suitable to take with your other medicines. Medicines which contain aspirin (such as some cold or flu remedies and painkillers) can interfere with sodium valproate.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with sodium valproate. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

• Gardez tous les médicaments hors de la portée et de la vue des enfants.

• Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.