Pommade à la tacrolimus
Protopic
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSLast updated 14 août 2023
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Tacrolimus ointment is for external use only and should be applied thinly to affected area(s) of skin.
Do not apply the ointment to any areas of skin which could be infected.
Expect to see an improvement within one week of using the ointment and then continue to use it for a few more weeks until the eczema has cleared.
Do not drink alcohol - it can make your skin (particularly on your face) become flushed or red, and feel hot.
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About tacrolimus ointment
Type de médicament | A topical immunomodulator |
Utilisé pour | Moderate-to-severe eczema in adults or in children over 2 years of age |
Aussi appelé | Protopic® |
Disponible sous forme de | Ointment |
Tacrolimus ointment helps reduce inflammatory skin reactions. It is prescribed for people with moderate-to-severe eczéma, usually as an alternative to other treatments such as steroid creams or ointments. It is applied topically (on to the skin) to reduce symptoms such as inflammation, redness and itching. Tacrolimus ointment is available in two strengths: 0.03% and 0.1%. Only the lower, 0.03% strength, is suitable for use by children. It will be prescribed initially by a skin specialist doctor.
Tacrolimus is also available as a medicine which is taken by mouth, but this is prescribed for a completely different medical condition. There is a separate information leaflet available about this, called Tacrolimus pour prévenir le rejet d'organe.
Before using tacrolimus ointment
Retour au sommaireSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using tacrolimus ointment it is important that your doctor knows:
Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.
If you have any other skin conditions.
If you have swollen lymph glands or a weakened immune system.
Si vous avez des problèmes avec le fonctionnement de votre foie.
If you have ever had an allergic reaction to a medicine, especially if it was to a macrolide antibiotic (such as erythromycin, clarithromycin, azithromycin or telithromycin).
Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.
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How to use tacrolimus ointment?
Retour au sommaireBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about the ointment and will provide you with a full list of the side-effects which you may experience from using it.
Apply a thin layer of ointment to the commonly affected areas of your skin twice daily (it is usually recommended that you apply it morning and evening). It can be applied to most areas of skin on your body, but do not apply it to areas such as your lips, the inside of your nose, or near to your eyes. Do not apply it to any area of skin that could be infected. Remember to wash your hands well with soap and water after using the ointment unless you are treating your hands.
If you forget to apply the ointment, apply it as soon as you remember and then continue as before.
Tirer le meilleur parti de votre traitement
Retour au sommaireEssayez de respecter vos rendez-vous réguliers avec votre médecin. Cela permet à votre médecin de suivre vos progrès.
Continue to use the ointment until your eczema has cleared. You should expect to see some improvement to your skin within one week of using the ointment, and it should be free from flares within a few more weeks. During this time, your doctor may ask you to reduce how often you apply the ointment or may reduce the strength of the ointment you are using.
Tacrolimus ointment is intended to be used for a short period of time (up to six weeks). It should not be used every day over a long period of time. Some people who frequently have flares may be prescribed the ointment to use on two days of each week to prevent further flares from developing. When it is used like this to prevent flares, there should be at least 2-3 days between applications.
You may continue to use moisturising creams and lotions whilst you are being treated with tacrolimus, but you should wait for at least two hours after you have applied tacrolimus ointment before applying them.
It is important that you don't cover any area of skin treated with tacrolimus with any dressings or bandages. This is because more of the medicine may be absorbed by your skin than is intended.
Do not drink alcohol because it can cause your skin and face to become flushed or red, and feel hot.
Your doctor will discuss with you the possibility of a slightly increased risk of cancer (particularly skin cancer) associated with medicines like tacrolimus. To help reduce this risk, do not use sunbeds, and avoid strong sunlight. On bright days, even if it is cloudy, use a sun cream with a high sun protection factor (an SPF of at least 15).
If there is no improvement in your skin after using tacrolimus ointment for two weeks, you should see your doctor again for further advice.
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Can tacrolimus ointment cause problems?
Retour au sommaireAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with tacrolimus ointment. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common tacrolimus ointment side-effects (these affect more than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
A burning sensation, itching | These symptoms generally disappear within one week |
Common tacrolimus ointment side-effects (these affect fewer than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
Redness, a feeling of warmth, pain, increased skin sensitivity to heat and cold, tingling, rash, local skin infections, cold sores | If any continue or become troublesome, speak with your doctor |
If you experience any other symptoms which you think may be due to the ointment, speak with your doctor or pharmacist for further advice.
How to store tacrolimus ointment?
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
Si vous subissez une opération ou un traitement dentaire, informez la personne effectuant le traitement des médicaments que vous utilisez.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
The ointment is for use on the skin only. If you suspect that someone has swallowed some of it, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Yellow Card website.

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Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Lectures complémentaires et références
- Manufacturer's PIL, Protopic® 0.1% Ointment; Leo Laboratories Ltd, The electronic Medicines Compendium. Dated June 2021.
- Manufacturer's PIL, Protopic® 0.03% ointment; Leo Laboratories Ltd, The electronic Medicines Compendium. Dated June 2021.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Next review due: 13 Aug 2026
14 août 2023 | Dernière version

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