Tolbutamide

About tolbutamide

Insulin is a hormone which is made naturally in your body, in the pancreas. It helps to control the levels of sugar (glucose) in your blood. If your body does not make enough insulin to meet its needs, or if it does not use the insulin it makes effectively, this results in the condition called diabète (diabète sucré).

People with diabetes need treatment to control the amount of sugar in their blood. This is because good control of blood sugar levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but for other people, medicines like tolbutamide are given alongside the changes in diet.

Tolbutamide works by increasing the amount of insulin that your pancreas produces. It can be given on its own or alongside other antidiabetic medicines or insulin.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking tolbutamide it is important that your doctor knows:

• Si vous êtes enceinte ou si vous allaitez.

• Si vous avez des problèmes avec le fonctionnement de votre foie, ou si vous avez des problèmes avec le fonctionnement de vos reins.

• If you have been told you have either porphyria or glucose-6-phosphate dehydrogenase (G6PD) deficiency. These are both rare inherited disorders.

• Si vous prenez d'autres médicaments. Cela inclut tous les médicaments disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.

• Si vous avez déjà eu une réaction allergique à un médicament.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about tolbutamide, and it will also provide you with a full list of the side-effects which you could experience from taking it.

• Take tolbutamide exactly as your doctor tells you to. It is usually prescribed as a once-daily dose of 1-3 tablets (500 mg strength) with breakfast, although some people are asked to take the tablets in divided doses over the day. Your doctor or pharmacist will tell you which is right for you, and this information will also be printed on the label of the pack of tablets to remind you about what the doctor said.

• If you are asked to take tolbutamide as a once-daily dose, take the tablets during your breakfast or immediately afterwards. If you are asked to take several doses of tolbutamide during a day, then take each of the doses during a mealtime or immediately afterwards. Swallow the tablets with a drink of water.

• If you forget to take a dose, take it at the next mealtime. Try to take the correct number of tablets each day, but do not take two doses together to make up for a missed dose.
  

• It is important that you keep your regular doctor's and clinic appointments. This is so your progress can be monitored. You are likely to need regular check-ups with an eye clinic and a foot clinic as well as with your doctor and diabetes clinic.

• Votre médecin peut vous recommander de tester régulièrement le taux de sucre (glucose) dans votre sang pour vérifier que votre diabète est bien contrôlé. Votre médecin ou votre infirmière spécialisée en diabète vous montrera comment faire.

• Si votre médecin vous a conseillé de modifier votre régime alimentaire, d'arrêter de fumer ou de faire de l'exercice régulièrement, il est important de suivre les conseils qui vous ont été donnés.

• Make sure you know what it feels like if your blood sugar is too low. This is known as hypoglycaemia, or a 'hypo'. The first signs of hypoglycaemia are feeling shaky or anxious, sweating, looking pale, feeling hungry, having a feeling that your heart is pounding (palpitations), and feeling dizzy. If this happens, eat something containing sugar, such as dextrose tablets, or sugary sweets or drinks (non-diet), and then follow this up with a snack such as a sandwich or a banana.

• Hypoglycaemia can occur in particular if you miss a meal, if you exercise more than usual, if you are ill, or if you drink a lot of alcohol.

• Si vous êtes conducteur, vous devez faire particulièrement attention, car votre capacité de concentration peut être affectée si votre diabète n'est pas bien contrôlé. Il peut vous être conseillé de vérifier votre glycémie avant de voyager et d'avoir une collation avec vous lors de longs trajets.

• Les conducteurs au Royaume-Uni peuvent avoir besoin d'informer l'Agence des permis de conduire et des véhicules (DVLA) s'ils subissent un épisode d'hypoglycémie sévère ou une 'hypo' en conduisant. Demandez conseil à votre médecin. Les conducteurs dans d'autres pays devraient contacter l'agence de permis de conduire pertinente.

• Consultez votre médecin avant de commencer tout nouvel exercice physique, car cela aura un effet sur votre glycémie et vous devrez peut-être vérifier vos niveaux de sucre dans le sang plus régulièrement.

• Drinking alcohol is not advisable with tolbutamide. If you do have a drink, keep well within the recommended alcohol limits, as alcohol will affect the control of your blood sugar.

• If you get unusually thirsty, pass urine more frequently, and feel very tired then let your doctor know. Your dose of tolbutamide may need adjusting.

• If you are due to have an operation or dental treatment, you should tell the person carrying out the treatment that you have diabetes and that you are taking tolbutamide.

• If you buy any medicines, check with a pharmacist that they are suitable for you to take. This is because some medicines may interfere with tolbutamide.

• Treatment for diabetes is lifelong. Continue to take the tablets unless you are advised otherwise by your doctor.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with tolbutamide. The best place to find a full list of the side-effects which can be associated with your medicine is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.

Si vous ressentez d'autres symptômes que vous pensez être dus aux comprimés, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.

• Gardez tous les médicaments hors de la portée et de la vue des enfants.

• Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.