activity dependent neuroprotector homeobox
Dernière mise à jour 18 Aug 2020
Respecte les directives éditoriales
- TéléchargerTélécharger
- Partager
- Language
- Discussion
- Version audio
- Ajouter aux sources préférées sur Google
La ADNP gene provides instructions for making a protein that helps control the activity (expression) of other genes through a process called chromatin remodeling. Chromatin is the network of DNA and protein that packages DNA into chromosomes. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged. Chromatin remodeling is one way gene expression is regulated during development; when DNA is tightly packed, gene expression is lower than when DNA is loosely packed. As part of the remodeling process, the ADNP protein attaches to DNA and interacts with groups of proteins called SWI/SNF complexes, which direct changes in the structure of chromatin.
Normal function
La ADNP gene provides instructions for making a protein that helps control the activity (expression) of other genes through a process called chromatin remodeling. Chromatin is the network of DNA and protein that packages DNA into chromosomes. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged. Chromatin remodeling is one way gene expression is regulated during development; when DNA is tightly packed, gene expression is lower than when DNA is loosely packed. As part of the remodeling process, the ADNP protein attaches to DNA and interacts with groups of proteins called SWI/SNF complexes, which direct changes in the structure of chromatin.
By regulating gene expression, the ADNP protein is involved in many aspects of development. It is particularly important for regulation of genes involved in normal brain development, and it likely controls the activity of genes that direct the development and function of other body systems.
Conditions referring to this gene or chromosome
Other names
activity-dependent neuroprotective protein
activity-dependent neuroprotector
activity-dependent neuroprotector homeobox protein
ADNP homeobox 1
ADNP1
HVDAS
KIAA0784
MRD28
Related patient information and medicines
Patient information leaflet
Ergothérapie
Ergothérapie is an essential part of health and social care, and plays a major role in helping people to cope with difficulties of daily living that may occur as a result of physical or mental health difficulties. Occupational therapy (OT) is a santé profession, working with individual patients to help them improve their lives at home, at.
Patient information leaflet
Vieillissement
Over time, life expectancy a doubled dans the UK. In 1841, baby boys were not expected to live past the age of 40.2 and girls not past 42.2. For babies born now in the UK, boys can be expected to live for 79.5 years, and girls 83.1 years... Poor health is more likely to make you dependent on other people. Sources of support available for ageing.
Patient information leaflet
Perte de mémoire et démence
The cause of Alzheimer's disease is not fully understood, but it is thought that abnormal proteins, called plaques and tangles, build up in the brain et stop it from working properly. Vascular dementia This is the second-most common cause of dementia in older people. Vascular dementia is caused by reduced blood flow to the brain, which damages.
Patient information leaflet
Exercice et activité physique
Doing regular physical activity can make people feel good about themselves and it can have a number of benefits for health. For example, it reduces the risk of developing heart disease , stroke . Ideally, the aim should be at least 30 minutes of moderate-intensity physical activity on at least five days of the week but even 10 minutes is better.
Patient information leaflet
Syndrome de fatigue chronique
Chronic fatigue syndrome (CFS), sometimes known as myalgic encephalomyelitis (ME) or myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) , is a condition where there is long-term disabling tiredness (fatigue). Most people with also have one or more other symptoms such as muscular pains, joint pains, disturbed sleep patterns, poor.
Patient information leaflet
Maladie de Huntington
Physiotherapy You may be referred to a physiotherapist f... Occupational therapy An occupational therapist may be able to help you with any adaptations that you need to make your day-to-day life easier. For example, they can help with adaptations to your home tel que wheelchair access, rails et modifications to your bedroom et bathroom. Orthophonie.
Lectures complémentaires et références
- activity dependent neuroprotector homeobox; MedlinePlus, National Library of Medicine.
- Helsmoortel C, Vulto-van Silfhout AT, Coe BP, Vandeweyer G, Rooms L, van den Ende J, Schuurs-Hoeijmakers JH, Marcelis CL, Willemsen MH, Vissers LE, Yntema HG, Bakshi M, Wilson M, Witherspoon KT, Malmgren H, Nordgren A, Anneren G, Fichera M, Bosco P, Romano C, de Vries BB, Kleefstra T, Kooy RF, Eichler EE, Van der Aa N. A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP. Nat Genet. 2014 Apr;46(4):380-4. doi: 10.1038/ng.2899. Epub 2014 Feb 16.
- Malishkevich A, Leyk J, Goldbaum O, Richter-Landsberg C, Gozes I. ADNP/ADNP2 expression in oligodendrocytes: implication for myelin-related neurodevelopment. J Mol Neurosci. 2015 Oct;57(2):304-13. doi: 10.1007/s12031-015-0640-4.
- Mandel S, Rechavi G, Gozes I. Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis. Dev Biol. 2007 Mar 15;303(2):814-24. doi: 10.1016/j.ydbio.2006.11.039. Epub 2006 Dec 1.
- Mandel S, Spivak-Pohis I, Gozes I. ADNP differential nucleus/cytoplasm localization in neurons suggests multiple roles in neuronal differentiation and maintenance. J Mol Neurosci. 2008 Jun;35(2):127-41. doi: 10.1007/s12031-007-9013-y. Epub 2008 Feb 20.
- Vandeweyer G, Helsmoortel C, Van Dijck A, Vulto-van Silfhout AT, Coe BP, Bernier R, Gerdts J, Rooms L, van den Ende J, Bakshi M, Wilson M, Nordgren A, Hendon LG, Abdulrahman OA, Romano C, de Vries BB, Kleefstra T, Eichler EE, Van der Aa N, Kooy RF. The transcriptional regulator ADNP links the BAF (SWI/SNF) complexes with autism. Am J Med Genet C Semin Med Genet. 2014 Sep;166C(3):315-26. doi: 10.1002/ajmg.c.31413. Epub 2014 Aug 28.
Participez à la conversation
Partagez vos pensées ou expériences avec les autres dans notre communautés de patients.
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.
Inscrivez-vous à la newsletter Patient
Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.