codanin 1
Dernière mise à jour 4 mars 2025
Respecte les directives éditoriales
- TéléchargerTélécharger
- Partager
- Language
- Discussion
- Version audio
- Ajouter aux sources préférées sur Google
The CDAN1 gene provides instructions for making a protein called codanin-1. Research suggests that codanin-1 plays an important role in maintaining the structure of the nucleus (where most of the cell's DNA is located). Specifically, codanin-1 is likely involved in putting together cell components called nucleosomes that help bundle DNA in a tight package. This tight packaging helps control gene expression.
Normal function
The CDAN1 gene provides instructions for making a protein called codanin-1. Research suggests that codanin-1 plays an important role in maintaining the structure of the nucleus (where most of the cell's DNA is located). Specifically, codanin-1 is likely involved in putting together cell components called nucleosomes that help bundle DNA in a tight package. This tight packaging helps control gene expression.
Because codanin-1 has the ability to regulate gene activity, it is involved in many processes during development, including the growth of cells as they progress through the step-by-step process for replication (the cell cycle). Codanin-1 is also thought to be involved in the differentiation and development of red blood cells (erythropoiesis), though the protein's specific role in this process is unclear.
Conditions referring to this gene or chromosome
Other names
CDA-I
CDA1
CDAN1_HUMAN
codanin
Related patient information and medicines
Patient information leaflet
Voyager vers des lieux éloignés
Self-treatment is a last resort as it is very difficult for anyone to make treatment decisions about themselves. Reference book Pocket First Aid et Wilderness Medicine: Drs Jim Duff and Peter Gormly (2010). This is an excellent handbook covering what to do as a layperson in most medical situations you might encounter. Equipment Thermom....
Patient information leaflet
Artérite à cellules géantes
This is why the condition is also called temporal arteritis. Giant cell arteritis (temporal arteritis) causes No one really knows exactly what causes giant cell arteritis (temporal arteritis). We do know that there are genetic changes in some people which make them more likely to develop giant cell (temporal) arteritis. Who is likely to develop.
Patient information leaflet
Dermatite séborrhéique
Dermatite séborrhéique cause bad dandruff and sometimes a rash, commonly on the face and upper body. An anti-yeast (antifungal) shampoo and/or an antifungal cream will usually clear the dandruff and rash. The first three in the list are available either over the counter or from your GP, and the last three would usually be given after consultation.
Patient information leaflet
Névralgie post-herpétique
Névralgie post-herpétique is a pain that persists in some people who have had shingles. It often eases and goes over time. Medication can often ease the pain. What is postherpetic neuralgia. Postherpetic neuralgia (PHN) is a nerve pain (neuralgia) that persists after the shingles rash has cleared. If the pain from shingles goes but then returns at a.
Patient information leaflet
Calculs rénaux
Kidney stones are hard stones that can cause severe pain in your side along with blood in your urine, and nausea and vomiting. You are more likely to develop kidney stones if you eat a Western diet, don't drink enough fluids or are overweight. Once you have had one episode they are likely to recur but there are several kidney stone treatment.
Patient information leaflet
Immunisation pneumococcique
Pneumococcus can cause diseases such as pneumonia, meningitis and blood infections. Children aged under 2 years should receive the vaccine. You should consider pneumococcal immunisation if you are aged over 65 years or have certain diseases of the lung, heart, kidney, liver and nervous system. What is the pneumococcus. Pneumococcus is a germ.
Lectures complémentaires et références
- codanin 1; MedlinePlus, National Library of Medicine.
- Ahmed MR, Chehal A, Zahed L, Taher A, Haidar J, Shamseddine A, O'Hea AM, Bienz N, Dgany O, Avidan N, Beckmann JS, Tamary H, Higgs D, Vyas P, Wood WG, Wickramasinghe SN. Linkage and mutational analysis of the CDAN1 gene reveals genetic heterogeneity in congenital dyserythropoietic anemia type I. Blood. 2006 Jun 15;107(12):4968-9. doi: 10.1182/blood-2006-01-0081. No abstract available.
- Dgany O, Avidan N, Delaunay J, Krasnov T, Shalmon L, Shalev H, Eidelitz-Markus T, Kapelushnik J, Cattan D, Pariente A, Tulliez M, Cretien A, Schischmanoff PO, Iolascon A, Fibach E, Koren A, Rossler J, Le Merrer M, Yaniv I, Zaizov R, Ben-Asher E, Olender T, Lancet D, Beckmann JS, Tamary H. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. Am J Hum Genet. 2002 Dec;71(6):1467-74. doi: 10.1086/344781. Epub 2002 Nov 14.
- Iolascon A, Andolfo I, Russo R. Congenital dyserythropoietic anemias. Blood. 2020 Sep 10;136(11):1274-1283. doi: 10.1182/blood.2019000948.
- Noy-Lotan S, Dgany O, Lahmi R, Marcoux N, Krasnov T, Yissachar N, Ginsberg D, Motro B, Resnitzky P, Yaniv I, Kupfer GM, Tamary H. Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated. Haematologica. 2009 May;94(5):629-37. doi: 10.3324/haematol.2008.003327. Epub 2009 Mar 31.
- Olijnik AA, Roy NBA, Scott C, Marsh JA, Brown J, Lauschke K, Ask K, Roberts N, Downes DJ, Brolih S, Johnson E, Xella B, Proven M, Hipkiss R, Ryan K, Frisk P, Makk J, Stattin EM, Sadasivam N, McIlwaine L, Hill QA, Renella R, Hughes JR, Gibbons RJ, Groth A, McHugh PJ, Higgs DR, Buckle VJ, Babbs C. Genetic and functional insights into CDA-I prevalence and pathogenesis. J Med Genet. 2021 Mar;58(3):185-195. doi: 10.1136/jmedgenet-2020-106880. Epub 2020 Jun 9.
- Renella R, Wood WG. The congenital dyserythropoietic anemias. Hematol Oncol Clin North Am. 2009 Apr;23(2):283-306. doi: 10.1016/j.hoc.2009.01.010.
- Russo R, Iolascon A, Andolfo I, Marra R, Rosato BE. Updates on clinical and laboratory aspects of hereditary dyserythropoietic anemias. Int J Lab Hematol. 2024 Aug;46(4):595-605. doi: 10.1111/ijlh.14307. Epub 2024 May 15.
- Tamary H, Dgany O, Proust A, Krasnov T, Avidan N, Eidelitz-Markus T, Tchernia G, Genevieve D, Cormier-Daire V, Bader-Meunier B, Ferrero-Vacher C, Munzer M, Gruppo R, Fibach E, Konen O, Yaniv I, Delaunay J. Clinical and molecular variability in congenital dyserythropoietic anaemia type I. Br J Haematol. 2005 Aug;130(4):628-34. doi: 10.1111/j.1365-2141.2005.05642.x.
- Tamary H, Dgany O. Congenital Dyserythropoietic Anemia Type I. 2009 Apr 21 [updated 2021 Jul 29]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK5313/
Participez à la conversation
Partagez vos pensées ou expériences avec les autres dans notre communautés de patients.
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.
Inscrivez-vous à la newsletter Patient
Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.