eukaryotic translation initiation factor 2 alpha kinase 4
Dernière mise à jour 10 Apr 2023
Respecte les directives éditoriales
- TéléchargerTélécharger
- Partager
- Language
- Discussion
- Version audio
- Ajouter aux sources préférées sur Google
La EIF2AK4 gene provides instructions for making a protein that helps direct a cell's response to changes that could damage the cell. This protein is found in several tissues throughout the body, including blood vessel walls. The EIF2AK4 protein can turn on (activate) another protein called eIF2 alpha (eIF2α), which helps control protein production. When cells are under stress, for example when the level of protein building blocks (amino acids) is too low, EIF2AK4 activates eIF2α. When turned on, eIF2α stimulates processes that reduce protein production, which helps conserve amino acids. In addition, activated eIF2α can trigger production of certain proteins called transcription factors, which control gene activity. The transcription factors regulated by eIF2α control the activity of genes involved in processes that help reduce the stress on the cell.
Normal function
La EIF2AK4 gene provides instructions for making a protein that helps direct a cell's response to changes that could damage the cell. This protein is found in several tissues throughout the body, including blood vessel walls. The EIF2AK4 protein can turn on (activate) another protein called eIF2 alpha (eIF2α), which helps control protein production. When cells are under stress, for example when the level of protein building blocks (amino acids) is too low, EIF2AK4 activates eIF2α. When turned on, eIF2α stimulates processes that reduce protein production, which helps conserve amino acids. In addition, activated eIF2α can trigger production of certain proteins called transcription factors, which control gene activity. The transcription factors regulated by eIF2α control the activity of genes involved in processes that help reduce the stress on the cell.
Conditions referring to this gene or chromosome
Other names
E2AK4_HUMAN
eukaryotic translation initiation factor 2-alpha kinase 4
GCN2
GCN2 eIF2alpha kinase
GCN2-like protein
general control nonderepressible 2
KIAA1338
PVOD2
Related patient information and medicines
Patient information leaflet
Myélofibrose
Myélofibrose is a serious bone marrow disorder that disrupts your body's normal production of blood cells. This leads to reduced levels of: Red blood cells (erythrocytes). This causes anaemia. It's not known what causes the genetic mutation in blood stem cells. The gene mutation that occurs in most people affected by la myélofibrose is a mutation.
Patient information leaflet
Maladies de stockage du glycogène
Maladies de stockage du glycogène are a group of inherited diseases. They result from a problem with one of the proteins (known as enzymes) involved in the conversion of glucose to glycogen, or the breakdown of glycogen back into glucose. They mostly tend to affect your liver and muscles. Most are diagnosed in childhood. Symptoms include weakness,.
Patient information leaflet
Cancer primitif du foie
This can be due to the growing cancer itself. It may also be due to ascites - fluid that builds up in the abdomen - which occurs with various liver disorders. What causes primary liver cancer. A cancerous (malignant) tumour starts from one abnormal cell. The exact reason why a cell becomes cancerous is unclear. It is thought that something damages.
Patient information leaflet
Tests de fonction hépatique
What are the main liver fonction tests. The usual liver function tests typically include the following: Bilirubin. Albumin. Total protein. Transferases (AST or SGOT and ALT or SGPT). Gamma GT. Creatine kinase. Prothrombin time or International Normalised Ratio (INR). Each of these is discussed below. The liver performs hundreds of different.
Patient information leaflet
Cancer de la bouche
Cancer de la bouche is also sometimes called oral cancer. Worldwide it is the sixth most common cancer. Although mouth cancer is uncommon in the UK, it seems to be getting much more common: the number of cases doubled in the 20 years from 1994 to 2014. There are around 7,500 cases diagnosed each year in the UK. It is twice as common in men as it is in.
Patient information leaflet
Faits et facteurs de risque du cancer du sein
Most cases of breast cancer occur by chance. However, breast cancer does occur more often than usual in some families because of their genetic makeup. Most cases of breast cancer occur by chance. However, breast cancer does occur more often than usual in some families because of their genetic makeup. Genetic means that the condition is passed on.
Lectures complémentaires et références
- eukaryotic translation initiation factor 2 alpha kinase 4; MedlinePlus, National Library of Medicine.
- Deval C, Chaveroux C, Maurin AC, Cherasse Y, Parry L, Carraro V, Milenkovic D, Ferrara M, Bruhat A, Jousse C, Fafournoux P. Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways. FEBS J. 2009 Feb;276(3):707-18. doi: 10.1111/j.1742-4658.2008.06818.x. Epub 2008 Dec 19.
- Donnelly N, Gorman AM, Gupta S, Samali A. The eIF2alpha kinases: their structures and functions. Cell Mol Life Sci. 2013 Oct;70(19):3493-511. doi: 10.1007/s00018-012-1252-6. Epub 2013 Jan 26.
- Eyries M, Montani D, Girerd B, Perret C, Leroy A, Lonjou C, Chelghoum N, Coulet F, Bonnet D, Dorfmuller P, Fadel E, Sitbon O, Simonneau G, Tregouet DA, Humbert M, Soubrier F. EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension. Nat Genet. 2014 Jan;46(1):65-9. doi: 10.1038/ng.2844. Epub 2013 Dec 1.
- Murguia JR, Serrano R. New functions of protein kinase Gcn2 in yeast and mammals. IUBMB Life. 2012 Dec;64(12):971-4. doi: 10.1002/iub.1090. Epub 2012 Nov 5.
Participez à la conversation
Partagez vos pensées ou expériences avec les autres dans notre communautés de patients.
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.
Inscrivez-vous à la newsletter Patient
Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.