integral membrane protein 2B
Dernière mise à jour 11 Apr 2022
Respecte les directives éditoriales
- TéléchargerTélécharger
- Partager
- Language
- Discussion
- Version audio
- Ajouter aux sources préférées sur Google
La ITM2B gene provides instructions for producing a protein called the integral membrane protein 2B (ITM2B), which is found in all tissues. The function of the ITM2B protein is unclear. It is thought to play a role in triggering the self-destruction of cells (apoptosis) and in keeping cells from growing and dividing too fast or in an uncontrolled way (suppressing tumour formation). Additionally, the ITM2B protein may be involved in processing the amyloid precursor protein, which is produced by the APP gene. Not much is known about amyloid precursor protein function, but it is thought to be involved in nerve cell function in the brain in early development. Processing this protein creates different forms of the protein that can carry out various functions. Research suggests that the ITM2B protein is also involved in preventing (inhibiting) a form of the amyloid precursor protein from accumulating in the body's cells and tissues.
Normal function
La ITM2B gene provides instructions for producing a protein called the integral membrane protein 2B (ITM2B), which is found in all tissues. The function of the ITM2B protein is unclear. It is thought to play a role in triggering the self-destruction of cells (apoptosis) and in keeping cells from growing and dividing too fast or in an uncontrolled way (suppressing tumour formation). Additionally, the ITM2B protein may be involved in processing the amyloid precursor protein, which is produced by the APP gene. Not much is known about amyloid precursor protein function, but it is thought to be involved in nerve cell function in the brain in early development. Processing this protein creates different forms of the protein that can carry out various functions. Research suggests that the ITM2B protein is also involved in preventing (inhibiting) a form of the amyloid precursor protein from accumulating in the body's cells and tissues.
Conditions referring to this gene or chromosome
Other names
ABRI
BRI2
BRICD2B
E25B
ITM2B_HUMAN
Related patient information and medicines
Patient information leaflet
Maladie de La Peyronie
Maladie de La Peyronie cause a curved or bent penis. It is caused by scar tissue forming along the shaft of the penis. This causes painful erections and a bend or curve, usually about halfway along the penis. The change in shape is usually only obvious when the penis is erect. Peyronie's disease symptoms Initial symptoms of Peyronie's disease.
Patient information leaflet
Syndrome néphrotique
Nephrotic syndrome is a condition where the 'filters' in the kidney become 'leaky' and large amounts of protéines leak from the blood into the urine. The main symptom is fluid retention (oedema) which is mainly due to the low protein level in the blood. It usually responds well to treatment with steroid medication taken by mouth and does not cause.
Patient information leaflet
Lymphome de Hodgkin
A means that you do not have symptoms of night sweats, h... B means that you do have one or more of these symptoms. As an example, if you have Stage 2B, it means that you have two or more groups of lymph nodes affected; however, both are either above or below the diaphragm and you also have one or more of night sweats, fevers or weight loss. By.
Patient information leaflet
Glomérulonéphrite
Glomérulonéphrite is the name given to a range of conditions that can affect the kidney, specifically the glomeruli of the kidney. The glomeruli become damaged, commonly because of a problem with the... Membranoproliferative glomerulonephritis - a glomerulus is made up de a membrane (the tiny blood vessels cela filter the blood) et le mesangium.
Patient information leaflet
Alimentation saine
The advice may be different for certain groups of people, including pregnant women, people with certain health problems or those with special dietary requirements. What are the benefits of healthy eating. The health risks... For this reason, the UK Government's Scientific Advisory Committee on Nutrition (SACN) recommend that your intake of red and.
Patient information leaflet
Travail
Labour is considered 'full-term' if it occurs between 37 and 42 weeks of pregnancy. Labour which occurs before 37 weeks of pregnan... We know that changing levels of hormones - particularly of prostaglandins (in the amniotic fluid that surrounds your baby) and oxytocin (produced by you in your pituitary gland just beneath your brain) are involved.
Lectures complémentaires et références
- integral membrane protein 2B; MedlinePlus, National Library of Medicine.
- Fotinopoulou A, Tsachaki M, Vlavaki M, Poulopoulos A, Rostagno A, Frangione B, Ghiso J, Efthimiopoulos S. BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production. J Biol Chem. 2005 Sep 2;280(35):30768-72. doi: 10.1074/jbc.C500231200. Epub 2005 Jul 18.
- Ghiso J, Rostagno A, Tomidokoro Y, Lashley T, Bojsen-Moller M, Braendgaard H, Plant G, Holton J, Lal R, Revesz T, Frangione B. Genetic alterations of the BRI2 gene: familial British and Danish dementias. Brain Pathol. 2006 Jan;16(1):71-9. doi: 10.1111/j.1750-3639.2006.tb00563.x.
- Kim J, Miller VM, Levites Y, West KJ, Zwizinski CW, Moore BD, Troendle FJ, Bann M, Verbeeck C, Price RW, Smithson L, Sonoda L, Wagg K, Rangachari V, Zou F, Younkin SG, Graff-Radford N, Dickson D, Rosenberry T, Golde TE. BRI2 (ITM2b) inhibits Abeta deposition in vivo. J Neurosci. 2008 Jun 4;28(23):6030-6. doi: 10.1523/JNEUROSCI.0891-08.2008.
- Revesz T, Ghiso J, Lashley T, Plant G, Rostagno A, Frangione B, Holton JL. Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view. J Neuropathol Exp Neurol. 2003 Sep;62(9):885-98. doi: 10.1093/jnen/62.9.885.
- Revesz T, Holton JL, Lashley T, Plant G, Frangione B, Rostagno A, Ghiso J. Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies. Acta Neuropathol. 2009 Jul;118(1):115-30. doi: 10.1007/s00401-009-0501-8. Epub 2009 Feb 19.
- Rostagno A, Revesz T, Lashley T, Tomidokoro Y, Magnotti L, Braendgaard H, Plant G, Bojsen-Moller M, Holton J, Frangione B, Ghiso J. Complement activation in chromosome 13 dementias. Similarities with Alzheimer's disease. J Biol Chem. 2002 Dec 20;277(51):49782-90. doi: 10.1074/jbc.M206448200. Epub 2002 Oct 17.
- Vidal R, Frangione B, Rostagno A, Mead S, Revesz T, Plant G, Ghiso J. A stop-codon mutation in the BRI gene associated with familial British dementia. Nature. 1999 Jun 24;399(6738):776-81. doi: 10.1038/21637.
- Vidal R, Revesz T, Rostagno A, Kim E, Holton JL, Bek T, Bojsen-Moller M, Braendgaard H, Plant G, Ghiso J, Frangione B. A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4920-5. doi: 10.1073/pnas.080076097.
Participez à la conversation
Partagez vos pensées ou expériences avec les autres dans notre communautés de patients.
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.
Inscrivez-vous à la newsletter Patient
Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.