secreted frizzled related protein 4
Dernière mise à jour 18 Aug 2020
Respecte les directives éditoriales
- TéléchargerTélécharger
- Partager
- Language
- Discussion
- Version audio
- Ajouter aux sources préférées sur Google
La SFRP4 gene provides instructions for making a protein called secreted frizzled-related protein 4 (SFRP4). This protein blocks (inhibits) a process called Wnt signaling. Wnt signaling plays an important role in the development of several tissues and organs throughout the body. In particular, regulation of this signaling process by SFRP4 is critical for normal bone development and remodeling. Bone remodeling is a normal process in which old bone is broken down and new bone is created to replace it. The SFRP4 protein also plays a role in the development of fatty (adipose) tissue.
Normal function
La SFRP4 gene provides instructions for making a protein called secreted frizzled-related protein 4 (SFRP4). This protein blocks (inhibits) a process called Wnt signaling. Wnt signaling plays an important role in the development of several tissues and organs throughout the body. In particular, regulation of this signaling process by SFRP4 is critical for normal bone development and remodeling. Bone remodeling is a normal process in which old bone is broken down and new bone is created to replace it. The SFRP4 protein also plays a role in the development of fatty (adipose) tissue.
Conditions referring to this gene or chromosome
Other names
frizzled protein, human endometrium
FRP-4
FRPHE
PYL
secreted frizzled-related protein 4 precursor
secreted frizzled-related protein 4; secreted frizzled-related protein 4
sFRP-4
Related patient information and medicines
Patient information leaflet
Artérite à cellules géantes
Giant cell arteritis (temporal arteritis) causes No one really knows exactly what causes artérite à cellules géantes (temporal arteritis). We do know that there are genetic changes in some people which make them more likely to develop giant cell (temporal) arteritis. Who is likely to develop giant cell arteritis (temporal arteritis). Giant cell.
Patient information leaflet
Malabsorption gastro-intestinale
Gastrointestinal malabsorption syndrome means a failure to fully absorb digested foods from the gut (bowel) into your body. There are many different causes. Prolonged intestinal malabsorption may cause problems because of a lack of carbohydrates, proteins, fats, minerals and vitamins that are essential to keep you healthy. The treatment will.
Patient information leaflet
Pancréatite aiguë
Vomir. A high temperature (fever) and generally feeling very unwell are common. Swollen abdomen. If the pancreatitis becomes severe and other organs become involved (for example, the heart, lungs or kidneys) then various other symptoms may develop. Dehydration and low blood pressure may develop. Acute pancreatitis can cause people to become.
Patient information leaflet
Prise de poids
Weight gain is rarely caused by simply eating more, or being less active, it is often more complicated than this. There are many possible causes of weight gain, and often a number of factors play a part. These may be social, cultural, societal, psychological or medical. What causes weight gain. Most simply, it might be due to taking in more.
Patient information leaflet
Cataractes
What are cataracts. Cataracts are cloudy (opaque) areas that develop in the lens of the eye. The lens should normally be clear. However, with cataracts, the affected l... You can’t always prevent cataracts, as they’re often linked to ageing. However, protecting your eyes from UV light, eating a healthy diet rich in antioxidants, not smoking, and.
Patient information leaflet
Syndrome néphrotique
Nephrotic syndrome is a condition where the 'filters' in the kidney become 'leaky' and large amounts of protein leak from the blood into the urine. The main symptom is fluid retention (oedema) which is mainly due to the low protein level in the blood. Various diseases can cause nephrotic syndrome, some more serious than others. Treatment and.
Lectures complémentaires et références
- secreted frizzled related protein 4; MedlinePlus, National Library of Medicine.
- Galada C, Shah H, Shukla A, Girisha KM. A novel sequence variant in SFRP4 causing Pyle disease. J Hum Genet. 2017 Apr;62(5):575-576. doi: 10.1038/jhg.2016.166. Epub 2017 Jan 19.
- Haraguchi R, Kitazawa R, Mori K, Tachibana R, Kiyonari H, Imai Y, Abe T, Kitazawa S. sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss. Sci Rep. 2016 Apr 27;6:25198. doi: 10.1038/srep25198.
- Kiper POS, Saito H, Gori F, Unger S, Hesse E, Yamana K, Kiviranta R, Solban N, Liu J, Brommage R, Boduroglu K, Bonafe L, Campos-Xavier B, Dikoglu E, Eastell R, Gossiel F, Harshman K, Nishimura G, Girisha KM, Stevenson BJ, Takita H, Rivolta C, Superti-Furga A, Baron R. Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease. N Engl J Med. 2016 Jun 30;374(26):2553-2562. doi: 10.1056/NEJMoa1509342.
- Visweswaran M, Schiefer L, Arfuso F, Dilley RJ, Newsholme P, Dharmarajan A. Wnt antagonist secreted frizzled-related protein 4 upregulates adipogenic differentiation in human adipose tissue-derived mesenchymal stem cells. PLoS One. 2015 Feb 25;10(2):e0118005. doi: 10.1371/journal.pone.0118005. eCollection 2015.
Participez à la conversation
Partagez vos pensées ou expériences avec les autres dans notre communautés de patients.
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.
Inscrivez-vous à la newsletter Patient
Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.