Malabsorption gastro-intestinale
Revu par Dr Colin Tidy, MRCGPDernière mise à jour par Dr Hayley Willacy, FRCGP Dernière mise à jour 30 nov. 2022
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Dans cette série :Maladie cœliaqueDermatite herpétiforme
Gastrointestinal malabsorption syndrome means a failure to fully absorb digested foods from the gut (bowel) into your body. There are many different causes. Prolonged intestinal malabsorption may cause problems because of a lack of carbohydrates, proteins, fats, minerals and vitamins that are essential to keep you healthy.
The treatment will depend on the cause of malabsorption but will also include supplements and other ways to make up for the reduced amount of carbohydrate, protein, fat, minerals and vitamins getting into your gastrointestinal tract.
En un coup d'œil
Gastrointestinal malabsorption means your gut cannot absorb enough nutrients from food.
Symptoms include tiredness, weight loss, and persistent diarrhoea.
Stools may be pale, bulky, smelly, and difficult to flush.
It can cause deficiencies such as iron, folate, and vitamin B12 deficiency.
Common causes in the UK are coeliac disease, Crohn's disease, and chronic pancreatitis.
Diagnosis involves blood tests, stool tests, and sometimes imaging scans.
Treatment focuses on the underlying cause and nutritional support.
What are the symptoms of gastrointestinal malabsorption?
There may be no symptoms if the malabsorption is mild and has not continued for very long. More severe or persistent malabsorption may lead to:
Fatigue (épuisement)
This is because of a lack of energy as you are not absorbing nutrients and essential vitamins and minerals from food.
Perte de poids
If you can't absorb enough energy (calories) from your food then this will cause you to lose weight (and may cause poor growth in children).
Persistent (chronic) diarrhoea
This is a common symptom of persistent malabsorption.
Pale, bulky and smelly stools (steatorrhoea)
This is because there is excessive fat in the stools and they become pale, bulky and very smelly. Fatty stools float and are difficult to flush away. They often leave a greasy rim around the pan.
Intestinal malabsorption may also cause:
Abnormal bleeding, caused by low vitamin K.
Œdème, which occurs because of insufficient protein and calories absorbed into the body.
There may also be other symptoms due to the particular underlying condition that is causing the malabsorption.
What are the causes of gastrointestinal malabsorption?
The most common causes in the UK are maladie cœliaque, maladie de Crohn and chronic pancreatitis. However, the malabsorption of simple carbohydrates affects about 1 in 4 people in Europe. Some diseases associated with malabsorption are found more often in some families - for example, coeliac disease, Crohn's disease, la fibrose kystique and lactose intolerance.
The causes of gastrointestinal malabsorption include:
Problems with absorbing food from the gut (bowel) into your body
Maladie cœliaque - a long-term disease that mostly affects the small intestine.
Soya milk intolerance.
Fructose intolerance.
Infection - for example, intestinal tuberculosis, la diarrhée du voyageur.
Immune deficiency - for example, infection par le VIH.
Pancreatic insufficiency - for example, la fibrose kystique, chronic pancreatitis, cancer du pancréas.
Structural causes
Malabsorption may be cause by loss of part of the bowel that is essential to absorb the broken down (digested) food into the body - for example:
Removal of the stomach or part of the bowel after a stomach or bowel operation.
Causes outside the bowel
Examples include:
Eating disorders: anorexie mentale, bulimia nervosa.
What tests are needed?
Initial tests will include analyses de sang et stool tests. Further tests may include an abdominal échographie, barium studies and a tomodensitométrie (TDM) ou un imagerie par résonance magnétique (IRM). Any further tests will depend on the likely underlying cause of the intestinal malabsorption.
What are the treatments for gastrointestinal malabsorption?
The treatment will mainly depend on the underlying cause of the malabsorption. However, treatment will also be needed to increase the amount of essential nutrients in the body, including carbohydrates, proteins, fats, minerals and fat-soluble vitamins (nutritional support).
Sélections des patients pour Problèmes intestinaux

Santé digestive
Maladie inflammatoire de l'intestin
La maladie inflammatoire de l'intestin (MII) est un terme utilisé pour décrire les personnes atteintes de l'un des deux principaux types de MII (la maladie de Crohn et la colite ulcéreuse). Ces deux affections peuvent provoquer une inflammation du côlon et du rectum (gros intestin) avec des symptômes similaires, tels que des diarrhées sanglantes, des douleurs abdominales, une perte de poids et un manque d'appétit.
par Dr Colin Tidy, MRCGP

Santé digestive
Polypes intestinaux
Les polypes intestinaux (polypes du côlon) sont de petites excroissances non cancéreuses (bénignes) sur la muqueuse interne de l'intestin (côlon et rectum).
par Dr Toni Hazell, MRCGP
Questions fréquemment posées
Can malabsorption be cured?
The treatment for malabsorption primarily focuses on addressing the underlying condition causing it. Therefore, whether it can be 'cured' depends on the specific cause. Additionally, part of the treatment involves ensuring the body receives essential nutrients like carbohydrates, proteins, fats, minerals, and fat-soluble vitamins through nutritional support.
What happens if fat is not absorbed properly?
If fat is not absorbed properly, it can lead to pale, bulky, and very smelly stools. These stools, known as steatorrhoea, contain excessive fat, often float, are difficult to flush, and can leave a greasy rim around the toilet pan.
Are there any health complications from long-term malabsorption?
Yes, long-term malabsorption can lead to several complications due to insufficient nutrient absorption. These include iron deficiency, iron-deficiency anaemia, folate deficiency, vitamin B12 deficiency, abnormal bleeding due to low vitamin K, and vitamin D deficiency, which can manifest as rickets or osteomalacia. Oedema can also occur because of insufficient protein and calories absorbed into the body.
Can malabsorption be caused by lifestyle factors like eating disorders?
Yes, malabsorption can be influenced by factors outside the bowel, including eating disorders such as anorexia nervosa and bulimia nervosa. An overactive thyroid gland (hyperthyroidism) can also be a cause.
Lectures complémentaires et références
- Zuvarox T, Belletieri C; Malabsorption Syndromes. StatPearls, July 2021.
- Ozaki RKF, Speridiao PDGL, Soares ACF, et al; Intestinal fructose malabsorption is associated with increased lactulose fermentation in the intestinal lumen. J Pediatr (Rio J). 2018 Nov - Dec;94(6):609-615. doi: 10.1016/j.jped.2017.08.006. Epub 2017 Oct 28.
- Montoro-Huguet MA, Belloc B, Dominguez-Cajal M; Small and Large Intestine (I): Malabsorption of Nutrients. Nutrients. 2021 Apr 11;13(4). pii: nu13041254. doi: 10.3390/nu13041254.
- Massironi S, Cavalcoli F, Rausa E, et al; Understanding short bowel syndrome: Current status and future perspectives. Dig Liver Dis. 2020 Mar;52(3):253-261. doi: 10.1016/j.dld.2019.11.013. Epub 2019 Dec 28.
- Brar HS, Aloysius MM, Shah NJ; Tropical Sprue. StatPearls, Jan 2023.
À propos de l'auteurVoir la biographie complète

Dr Colin Tidy, MRCGP
Médecin généraliste, Auteur médical
MBBS, MRCGP, MRCP (Paediatrics), DCH
Le Dr Colin Tidy est un médecin du NHS, basé dans l'Oxfordshire.
À propos du critiqueVoir la biographie complète

Dr Colin Tidy, MRCGP
Médecin généraliste, Auteur médical
MBBS, MRCGP, MRCP (Paediatrics), DCH
Le Dr Colin Tidy est un médecin du NHS, basé dans l'Oxfordshire.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Article également disponible en Anglais, Allemand, Espagnol, Français, Italien, Portugais, Hindi, Hébreu, Arabe, and Suédois.
Prochaine révision prévue : 2 nov. 2027
30 nov. 2022 | Dernière version
1 Aug 2017 | Publié à l'origine
Écrit par :
Dr Colin Tidy, MRCGP

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