Can I take Amitriptyline and Oxypro together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking amitriptyline and OxyPro (oxycodone) together can cause extreme sleepiness, dizziness, and severe breathing difficulties. It may also lead to a rare but serious condition called serotonin syndrome, which can cause confusion, sweating, and muscle twitching.
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Why this happens
Both drugs slow down the central nervous system (brain and spinal cord). Amitriptyline also increases serotonin levels, which can be further affected by oxycodone, leading to a dangerous buildup. Additionally, amitriptyline can slow down the body's ability to process oxycodone, making its effects stronger and longer-lasting.
What you should do
You must speak to your doctor before taking these medicines together. If your doctor prescribes both, they will likely start you on the lowest possible doses. Seek immediate medical help if you feel unusually sleepy, have trouble breathing, or feel very confused.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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