Can I take Amlodopine and Naproxen together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking naproxen can make amlodipine less effective at lowering your blood pressure. Additionally, using both together can increase the strain on your kidneys and may lead to fluid retention (swelling).
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Why this happens
Amlodipine works by relaxing blood vessels to lower blood pressure. Naproxen belongs to a group of medicines called NSAIDs, which can cause the body to hold onto salt and water. Naproxen also blocks certain natural chemicals (prostaglandins) that help keep blood vessels open and kidneys functioning well. This directly opposes the blood-pressure-lowering effect of amlodipine.
What you should do
If you need to take naproxen for a short time (a few days), monitor your blood pressure more frequently. If you need long-term pain relief, speak to your doctor or pharmacist about safer alternatives, such as paracetamol. Seek medical advice if you notice swelling in your ankles, decreased urination, or a significant rise in your blood pressure readings.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Clause de non-responsabilité
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
25 janvier 2026 | Publié à l'origine
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