Comprimés de bupropion pour aider à arrêter de fumer
Zyban
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSLast updated 9 Nov 2023
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A combination of bupropion with counselling can increase your chance of successfully stopping smoking.
Start taking the tablets at least a week before your target stop date.
The most common side-effect is difficulty sleeping - the risk of this is less if you avoid taking doses near bedtime.
At a glance
Bupropion (Zyban®) is a medicine used to help people stop smoking.
It can help to relieve nicotine withdrawal symptoms like cravings and anxiety.
You still need determination to quit smoking, and counselling increases success.
You typically start taking it a week before your chosen 'quit' date.
Common side-effects include difficulty sleeping, feeling dizzy, and headache.
Tell your doctor if you feel depressed or have thoughts of harming yourself.
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About bupropion
Type de médicament | A smoking cessation aid |
Utilisé pour | Helping people to stop smoking |
Aussi appelé | Zyban® |
Disponible sous forme de | Comprimés |
Nicotine is a drug that is inhaled from the tobacco in cigarettes. It gets into the bloodstream, and stimulates the brain. Most regular smokers are addicted to nicotine. Even though you want to quit smoking, it can be difficult to succeed, because nicotine addiction is strong and hard to break. This is where bupropion can help.
Stopping smoking in somebody who smokes regularly causes a reduction of some chemicals in the brain. This leads to withdrawal symptoms such as cravings, anxiety, irritability and other symptoms associated with 'giving up'. Bupropion alters the levels of some of these chemicals and this is possibly how it relieves the withdrawal symptoms.
Bupropion does not 'make' you stop smoking. You still need determination to succeed and to break the smoking habit. A combination of bupropion with counselling from a nurse, doctor, pharmacist, or other health professional increases your chance of successfully stopping smoking. Therefore, most doctors will only prescribe bupropion to people who really want to stop smoking as part of a 'stopping smoking' programme.
Bupropion is also available as a combination product to support weight loss. If you are taking bupropion for this purpose and you need additional information, ask your pharmacist or doctor for advice.
Before taking bupropion
Retour au sommaireSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking bupropion it is important that your doctor knows:
If you are under 18 years of age, or over 65 years old.
Si vous êtes enceinte ou si vous allaitez.
Si vous avez des problèmes avec le fonctionnement de votre foie, ou des problèmes avec le fonctionnement de vos reins.
If you have diabetes (diabetes mellitus).
If for any reason you are at risk of having a seizure.
If you have ever had an eating disorder, such as anorexia nervosa or bulimia.
If you have bipolar disorder.
Si vous avez une affection inflammatoire appelée lupus érythémateux systémique (également appelé lupus, ou LES).
If you regularly drink a lot of alcohol or if you have a drug problem.
If you have been told you have a tumour of the brain or spinal cord, or if you have ever had a serious head injury.
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines. This is particularly important if you are taking digoxin for a heart condition. Your dose of digoxin may need to be adjusted before or after treatment with bupropion.
Si vous avez déjà eu une réaction allergique à un médicament.
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How to take bupropion
Retour au sommaireBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about bupropion and stopping smoking. It will also provide you with a full list of the side-effects which can be associated with bupropion.
Take bupropion exactly as your doctor tells you to. You will be asked to set yourself a date on which to stop smoking. Your doctor will then ask you to start taking bupropion tablets at least a week before this 'quit' date. The aim is to build up the dose so that your body gets used to the medicine before your quit date.
Start by taking one tablet (150 mg) each day for the first six days. Then from day seven onwards, take one tablet twice a day (unless you are told otherwise by your doctor). Make sure that you leave at least eight hours between the doses. Ideally, take one tablet in the morning and one early evening. Remember to stop smoking on the day you have set as your quit date.
It is not important whether you take bupropion tablets before or after food, but it is best if you try to take your doses at the same time(s) each day. This will help you to remember to take the tablets regularly.
Swallow the tablets whole with a glass of water - do not chew or break the tablets before you swallow.
If you forget to take a dose, leave out the missed dose but make sure that you remember to take your next dose when it is due. Do not take two doses together to make up for the forgotten dose.
Tirer le meilleur parti de votre traitement
Retour au sommaireTry to keep your regular appointments with your doctor or nurse. This is so that you can be given counselling and encouragement, and also so that a check can be kept on your progress. You will also need to have your blood pressure measured regularly, as this can increase in some people.
Make sure that your doctor or healthcare professional knows if you are taking any other medicines. This is because stopping smoking can change the way your body breaks down certain medicines. So, as a result of quitting, the dose of some prescribed medicines may need to be adjusted.
A full course of treatment with bupropion will last for 7-9 weeks in total. If you are still smoking after seven weeks, let your doctor know about this so that you can discuss the options that are available to you.
After your course of treatment, your doctor may suggest that you gradually reduce the dose over a few days before you finally stop taking the tablets.
Si vous achetez des médicaments, vérifiez toujours avec un pharmacien qu'ils sont sûrs à prendre avec vos autres médicaments.
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Can bupropion cause problems?
Retour au sommaireAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with bupropion. You will find a full list in the manufacturer's information leaflet supplied with your medicine. Some of the symptoms may also occur as a result of stopping smoking.
Common bupropion side-effects | Que puis-je faire si je ressens cela ? |
Difficulté à dormir | Try to avoid taking your last dose near to bedtime |
Feeling dizzy, difficulty concentrating | If this happens, do not drive and do not use tools or machines until you feel better |
Maux de tête | Buvez beaucoup d'eau et demandez à votre pharmacien de vous recommander un antidouleur approprié. Si les maux de tête persistent, informez votre médecin |
Bouche sèche | Essayez de mâcher du chewing-gum sans sucre ou de sucer des bonbons sans sucre |
Feeling sick (nausea) or being sick (vomiting), stomach upset | Keep to simple foods. Try taking the tablets after meals |
Constipation | Mangez une alimentation équilibrée et buvez beaucoup d'eau chaque jour |
Mood changes, changes to the way things taste, feeling shaky, itchy rash, sweating, high temperature (fever) | Si cela pose problème, parlez-en à votre médecin |
Important: if you feel depressed or start having thoughts about harming yourself, you must let your doctor know immédiatement. Depression can occur as a symptom of nicotine withdrawal and it can also on occasion occur as a result of taking bupropion.
Dans de rares occasions, les médicaments qui affectent le niveau de sérotonine dans le cerveau peuvent le faire monter trop haut et causer des problèmes. Le risque est plus élevé si vous prenez plus d'un médicament ayant cet effet. Consultez un médecin si vous développez une combinaison des symptômes suivants :
Muscles raides ou mouvements 'saccadés'.
Rythme cardiaque inhabituellement rapide.
Température élevée (fièvre), sensation de malaise (nausée) ou vomissements, diarrhée.
Se sentir délirant ou voir des visions (halluciner).
Si vous ressentez d'autres symptômes que vous pensez être dus aux comprimés, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.
How to store bupropion
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
This medicine is for you. Do not give it to others, even if their condition appears to be the same as yours.
If you are having any medical treatment, tell the person carrying out the treatment which medicines you are taking.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
If you have any questions about your medicines, ask your pharmacist.
MHRA - Signaler des réactions indésirables
Signalez les effets secondaires suspectés des médicaments, vaccins, cigarettes électroniques, incidents liés aux dispositifs médicaux, produits défectueux ou falsifiés (contrefaits) à l'Agence de Régulation des Médicaments et Produits de Santé pour garantir une utilisation sûre et efficace.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
How does bupropion help me stop smoking?
Bupropion works by altering the levels of certain chemicals in your brain. When you stop smoking, a reduction in these chemicals can cause withdrawal symptoms like cravings, anxiety, and irritability. Bupropion helps to relieve these symptoms, making it easier to manage the process of quitting.
Do I still need to try hard to quit smoking if I'm taking bupropion?
Yes, bupropion doesn't make you stop smoking automatically. You still need determination to succeed and break the habit. Bupropion is most effective when combined with counselling from a healthcare professional as part of a 'stopping smoking' programme, which significantly increases your chances of stopping successfully.
How long will I be on bupropion treatment?
A full course of treatment with bupropion typically lasts for 7-9 weeks. Your doctor will monitor your progress during this time.
Can I take bupropion if I'm pregnant or breastfeeding?
If you are pregnant or breastfeeding, it is important to let your doctor know before starting bupropion. They will need to assess if the medicine is suitable for you in this situation.
My blood pressure is usually fine, why do I need to have it checked regularly while on bupropion?
It's important to have your blood pressure measured regularly while taking bupropion because it can increase in some people. Your doctor or nurse will monitor this to ensure your safety and well-being during the treatment.
What should I do if I feel really low or start thinking about harming myself while taking bupropion?
It is crucial to let your doctor know straightaway if you feel depressed or start having thoughts about harming yourself. Depression can be a symptom of nicotine withdrawal, and it can also occasionally occur as a result of taking bupropion. This needs immediate medical attention.
Can I just stop taking bupropion once I've completed the course?
After your course of treatment is finished, your doctor may suggest that you gradually reduce the dose over a few days before you completely stop taking the tablets. Always follow their advice on how to stop the medication.
Lectures complémentaires et références
- Manufacturer's PIL, Zyban® 150 mg prolonged-release film-coated tablets; GlaxoSmithKline UK, The electronic Medicines Compendium, August 2023.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Next review due: 8 Nov 2026
9 Nov 2023 | Dernière version

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