Cyclosérine pour la tuberculose
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 1 Jun 2025
Respecte les directives éditoriales
- TéléchargerTélécharger
- Partager
- Language
- Discussion
- Version audio
- Ajouter aux sources préférées sur Google
Cycloserine is one of several medicines you will need to take to treat tuberculosis (TB).
You will need to have regular blood tests while you are taking the medicine.
It is important that you take your doses regularly, every 12 hours.
En un coup d'œil
Cycloserine is a medicine used to treat tuberculosis (TB).
It is prescribed when other common TB medicines are unsuitable or ineffective.
Take capsules regularly, usually twice a day, with or without food.
Do not drink alcohol or stop taking cycloserine without your doctor's advice.
Tell your doctor if you experience severe headaches, dizziness, confusion, or fits.
About cycloserine
Type de médicament | An antituberculosis medicine |
Utilisé pour | Tuberculose (TB) |
Disponible sous forme de | Capsules |
Cycloserine is used to treat la tuberculose (TB). TB is a bacterial infection which mostly affects the lungs, but which can affect any part of your body. TB is treatable with a course of medicines which usually lasts for six months. You will need to take several medicines to treat TB - cycloserine is one of the medicines used. Cycloserine will be prescribed for you if other more frequently prescribed antituberculosis medicines are either not suitable for you, or have not been effective for you.
Cycloserine works by acting on the cell walls of the germs (bacteria) responsible for the TB. The cell walls do not form correctly which causes them to break, killing the bacteria.
Cycloserine will be prescribed for you by a doctor who specialises in the treatment of TB. It is important that you take it regularly.
Before taking cycloserine
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking cycloserine it is important that your doctor knows:
Si vous êtes enceinte ou si vous allaitez.
If you drink a lot of alcohol.
If you have any mental health problems, such as anxiety, depression or psychosis.
If you have any problems with how your liver works, or any problems with the way your kidneys work.
If you have a condition that causes fits, such as epilepsy.
Si vous avez un trouble sanguin héréditaire rare appelé porphyrie.
Si vous prenez d'autres médicaments. Cela inclut tous les médicaments disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.
Si vous avez déjà eu une réaction allergique à un médicament.
How to take cycloserine
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about cycloserine and will provide you with a full list of the side-effects which you could experience from taking it.
Take the capsules exactly as your doctor tells you to. As a guide, the usual dose to begin with in adults is one capsule twice a day, taken 12 hours apart (morning and evening). After two weeks, your dose may be increased to two capsules twice a day, depending on the result of a blood test.
Try to take your doses of cycloserine at the same times of day each day, as this will help you to remember to take your doses regularly. You can take the capsules either with or without food.
If you forget to take a dose, take it as soon as you remember. Try to take the correct number of doses each day, but do not take two doses at the same time to make up for a missed dose.
Tirer le meilleur parti de votre traitement
It is important that you keep your regular appointments with your doctor, or clinic. This is so your doctor can check on your progress. Your doctor will want you to have blood tests during the treatment, to make sure you have just the right amount of the medicine in your bloodstream. For some people, these tests can be as regular as once a week.
Continue to take the capsules regularly - do not stop taking cycloserine unless your doctor tells you to stop. This is because it is important for you to complete the course of medicine so that the infection does not come back. Your treatment will last for several months.
Do not to drink alcohol while you are on cycloserine. Cycloserine causes drowsiness, and drinking alcohol will increase the chance that you experience this side-effect. It also increases the risk of more serious side-effects, such as fits (convulsions).
Cycloserine can stop the oral typhoid vaccine from working properly. If you are due to have any vaccinations, make sure that the person treating you knows you are taking this medicine. Also, if you are due to have an operation or any dental treatment, you should tell the person carrying out the treatment that you are taking cycloserine for TB.
If you buy any medicines 'over the counter', check with a pharmacist that they are suitable for you to take alongside your prescribed medicines.
Can cycloserine cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with cycloserine. You will find a full list in the manufacturer's information leaflet supplied with the medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Cycloserine side-effects | Que puis-je faire si je ressens cela ? |
Maux de tête | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. Let your doctor know if the headache continues |
Feeling dizzy or sleepy, a spinning sensation (called vertigo) | Ne conduisez pas et n'utilisez pas d'outils ou de machines. Ne buvez pas d'alcool |
Feeling shaky, fits, feeling confused, mood or character changes, allergic skin rashes | Let your doctor know as soon as possible if you experience any of these |
Changes to the results of some blood tests (such as those checking your liver and blood) | Votre médecin surveillera ceux-ci |
Si vous ressentez d'autres symptômes que vous pensez être dus aux capsules, veuillez consulter votre médecin ou votre pharmacien pour obtenir des conseils supplémentaires.
How to store cycloserine
Gardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous immédiatement au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
What happens if I accidentally take two doses at once?
If you forget to take a dose, you should take it as soon as you remember. However, it's important not to take two doses at the same time to make up for a missed dose. If you accidentally take too much, or suspect an overdose, you should go to the accident and emergency department of your local hospital immediately and take the medicine container with you.
What should I do if I notice changes in my mood or behaviour while taking cycloserine?
If you experience serious side-effects like feeling shaky, having fits, feeling confused, or noticing changes in your mood or character, you should let your doctor know as soon as possible. Your doctor will monitor your progress and blood tests throughout your treatment.
Will I have to take cycloserine for the entire six-month TB treatment?
Cycloserine is one of the medicines used to treat TB, and your treatment course for TB will last for several months. It is important to continue taking cycloserine regularly and not to stop unless your doctor tells you to. This ensures the infection does not return.
Can I drive or operate machinery while taking cycloserine?
Cycloserine can cause side-effects such as feeling dizzy, sleepy, or experiencing a spinning sensation (vertigo). If you experience these, you should not drive or use tools or machines.
What should I do with any leftover cycloserine capsules once my treatment is finished?
You should not keep out-of-date or unwanted medicines. Take any unused cycloserine to your local pharmacy, and they will dispose of them for you.
Lectures complémentaires et références
- Manufacturer's PIL, Cycloserine 250 mg capsules; Neon Healthcare Ltd, The electronic Medicines Compendium. Dated May 2023.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
À propos de l'auteurVoir la biographie complète

Michael Stewart, MRPharmS
Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien
BPharm (Hons), MRPharmS
Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.
À propos du critique

Sid Dajani
Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Article également disponible en Anglais, Allemand, Espagnol, Français, Italien, Portugais, Hindi, Hébreu, Arabe, and Suédois.
Prochaine révision prévue : 1 juin 2028
1 Jun 2025 | Dernière version

Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.
Inscrivez-vous à la newsletter Patient
Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.
Plus dans le traitement des infections
- Crème d'aciclovir
- Cefaclor pour infection
- Cefadroxil pour l'infection
- Cefixime pour infection
- Préparations ophtalmiques de ciprofloxacine
- Clarithromycine pour infection
- Crème de clindamycine pour la vaginose bactérienne
- Co-fluampicil pour l'infection
- Fluconazole pour les infections fongiques
- Griséofulvine pour les infections fongiques
- Itraconazole pour les infections fongiques
- Mebendazole
- Miconazole pour le muguet buccal
- Moxifloxacine pour les infections oculaires
- Mupirocine pour infections cutanées
- Nystatine pour le muguet buccal
- Posaconazole pour les infections fongiques
- Rifampicine pour infection
- Fusidate de sodium pour les infections
- Comprimés de sulfadiazine