Lubiprostone pour la constipation
Amitiza
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 19 sept. 2023
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Note de l'auteur clinique Michael Stewart 24/8/2020: Amitiza® capsules were discontinued in the UK in January 2019. At the time of review there are no branded or generic products containing lubiprostone available in the UK. Lubiprostone may still be available in other countries. This medicine leaflet is based on medical information available in the UK at the time of writing and is left here for reference purposes. Please also refer to the manufacturer's information supplied with your medicine.
Take one capsule twice daily for at least two weeks.
Take the capsules with food.
The most common side-effects are feeling sick, diarrhoea and headache.
En un coup d'œil
Lubiprostone is a medicine for constipation, also known as Amitiza®.
It works by increasing fluid in the bowel, which helps to make stools easier to pass.
Take one capsule twice daily, after breakfast and after supper, with food and water.
Common side-effects include feeling sick and diarrhoea.
See your doctor if you do not notice any improvement after two weeks or if side-effects are troublesome.
Dans cet article:
Sélections vidéo pour Traitement gastro-intestinal
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About lubiprostone
Type de médicament | A chloride-channel activator |
Utilisé pour | Constipation |
Aussi appelé | Amitiza® (discontinued) |
Disponible sous forme de | Capsules |
Constipation chez les adultes is a common problem. It means either going to the toilet less often than usual to empty the bowels, or passing hard or painful stools when you do go. It can be caused by not eating enough fibre or not drinking enough fluids, or a lack of exercise or movement (such as being ill in bed). It can also be a side-effect of certain medicines (such as some painkillers), or related to an underlying medical condition. In many cases, the cause is not clear.
Lubiprostone helps to increase secretion of fluid into the bowel. This increases the movement of the bowels, making stools easier to pass. It is helpful for people for whom constipation remains a problem despite recommended changes to lifestyle or diet.
Before taking lubiprostone
Retour au sommaireSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking lubiprostone it is important that your doctor knows:
Si vous êtes enceinte ou si vous allaitez.
Si vous êtes tellement constipé que vous pensez avoir une obstruction.
Si vous avez des problèmes avec le fonctionnement de votre foie.
If you have low blood pressure (hypotension).
Si vous avez déjà eu une réaction allergique à un médicament.
Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.
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How to take lubiprostone
Retour au sommaireBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about lubiprostone and a full list of the side-effects which you may experience from taking it.
Take lubiprostone exactly as your doctor tells you to. The usual dose is one capsule twice daily. A course of treatment lasts for two to four weeks. Swallow the capsule with a drink of water after a meal, or with a snack. The ideal times to take the capsules are after breakfast and after supper.
If you forget to take a dose, leave out the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
Tirer le meilleur parti de votre traitement
Retour au sommaireRemember to keep any regular appointments with your doctor. This is so your doctor can check on your progress.
If you have been taking lubiprostone for two weeks and have not noticed any improvement in your symptoms, let your doctor know.
A healthy diet containing fibre (wholegrain breads and cereals, bran, fruit and green leafy vegetables) with several glasses of water each day and daily exercise are important in maintaining healthy bowel function.
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Can lubiprostone cause problems?
Retour au sommaireAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with lubiprostone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common lubiprostone side-effects (these affect more than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
Sensation de malaise (nausée) | Make sure you take the capsules during a meal |
Common lubiprostone side-effects (ces effets touchent moins de 1 personne sur 10) | Que puis-je faire si je ressens cela ? |
Diarrhée | Drink plenty of water. If the diarrhoea is severe, let your doctor know |
Maux de tête | Buvez beaucoup d'eau et demandez à votre pharmacien de vous recommander un antidouleur approprié. Si les maux de tête persistent, informez votre médecin |
Chest tightness, feeling short of breath | Let your doctor know about this so that your treatment can be reviewed |
Sensation de vertige | Do not drive and do not use tools or machines while you feel dizzy |
Increased sweating, feeling flushed, swollen feet or ankles, stomach upset | Si cela pose problème, parlez-en à votre médecin |
Si vous ressentez d'autres symptômes que vous pensez être dus aux capsules, consultez votre médecin ou votre pharmacien pour obtenir des conseils supplémentaires.
How to store lubiprostone
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Store in a cool, dry place, away from direct heat and light. The capsules can absorb moisture from the air so it is important to keep them in their original container to keep them dry. Do not keep the capsules for longer than four weeks after the container is first opened.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.
If you buy any medicines, always check with a pharmacist that they are suitable for you to take with your other medicines.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
What is the main difference between lubiprostone and other constipation remedies I might have tried?
Lubiprostone works by increasing the amount of fluid secreted into your bowel. This added fluid helps to increase bowel movement, which makes your stools softer and easier to pass. It is typically prescribed if constipation continues to be an issue even after you have tried recommended lifestyle and dietary changes.
How long will I need to take lubiprostone for it to be effective?
A typical course of treatment with lubiprostone lasts for two to four weeks. If you haven't noticed any improvement in your constipation symptoms after two weeks, you should inform your doctor.
Are there any foods or drinks I should avoid while taking lubiprostone?
The article does not specify any foods or drinks to avoid while taking lubiprostone. However, it does highlight the importance of a healthy diet rich in fibre, along with several glasses of water daily, and regular exercise to maintain healthy bowel function.
What should I do if I experience chest tightness or feel short of breath after taking lubiprostone?
If you experience chest tightness or feel short of breath, you should inform your doctor. This allows them to review your treatment and provide further advice.
Can I take other medications, including over-the-counter ones, while on lubiprostone?
Before starting lubiprostone, it's important to tell your doctor about all other medicines you are taking. This includes any medicines bought without a prescription, as well as herbal and complementary medicines, as some medicines can interact with lubiprostone. Always check with a pharmacist if you buy any new medicines to ensure they are suitable to take with lubiprostone.
How should I store lubiprostone capsules?
Lubiprostone capsules should be stored in a cool, dry place, away from direct heat and light. It is important to keep them in their original container to protect them from moisture. Also, do not keep the capsules for longer than four weeks after you first open the container.
What should I do if I accidentally take more than the prescribed dose?
If you suspect that you or someone else has taken too much lubiprostone, you should go to the accident and emergency department of your local hospital immediately. Remember to take the medicine container with you, even if it is empty.
Lectures complémentaires et références
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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À propos de l'auteurVoir la biographie complète

Michael Stewart, MRPharmS
Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien
BPharm (Hons), MRPharmS
Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.
À propos du critique

Sid Dajani
Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Prochaine révision prévue : 18 sept. 2026
19 sept. 2023 | Dernière version

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