Aurothiomalate de sodium pour l'arthrite

About sodium aurothiomalate

Polyarthrite rhumatoïde (PR) is thought to be an autoimmune disease. Your immune system normally makes antibodies to protect you from germs such as bacteria and viruses. In people with autoimmune diseases, the immune system makes antibodies that attack the tissues of the body, although it is not clear why this happens. Sodium aurothiomalate belongs to a group of medicines known as médicaments antirhumatismaux modificateurs de la maladie (DMARDs) and works by suppressing your immune system. It helps to stop your immune system from attacking the tissues of your body and it reduces the damaging effect of the disease on your joints. It is sometimes referred to as 'gold therapy'.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start having sodium aurothiomalate injections it is important that your doctor or pharmacist knows:

• Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.

• If you have ever had eczema, dermatitis, or a severe itchy skin condition.

• Si vous avez des problèmes de respiration.

• Si vous avez des problèmes de foie ou de reins.

• If you have ever had a problem with your bowels, called colitis.

• If you have ever had a blood or bone marrow disorder.

• If you have been told you have systemic lupus erythematosus. This is also an autoimmune disease causing inflammation.

• If you have porphyria, a rare inherited blood condition.

• Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.

• If you have ever had an allergic reaction to a medicine.
  

• Before you start this treatment, ask to read the manufacturer's printed information leaflet from inside the pack. The leaflet will give you more information about sodium aurothiomalate injections and a full list of side-effects which you may experience from having it.

• Sodium aurothiomalate injections will be given to you by a doctor or nurse who is a specialist. It is given by injection into a muscle.

• If you haven't had an injection of sodium aurothiomalate before, you will be given a small dose as a test before you are given a normal dose. This is to see how well you tolerate the injection.

• You will be started on a course of regular weekly injections. The usual starting dose is 50 mg. If you respond well to the treatment, the time between your injections will be increased after some months to every two weeks, then every three weeks, and then every four weeks. Treatment with sodium aurothiomalate may be continued for several years.

• It is important that you have the injections regularly. If you miss an appointment for an injection, you should contact your clinic to make another appointment as soon as possible.

• It is important that you keep your regular appointments with your hospital clinic for your injections. Your progress will also be monitored during these regular clinic visits, and your doctor will arrange for you to have regular blood and urine tests. Once a year your doctor will arrange for you to have a chest X-ray to make sure your lungs are working properly. This is because the injections can affect your breathing.

• You should expect that sodium aurothiomalate will build up its effect gradually. This means that you may not notice the full benefit until after 2-6 months of treatment.

• Many people receiving sodium aurothiomalate are also prescribed an anti-inflammatory painkiller for several weeks until it starts to work. Once working, the dose of the anti-inflammatory tablet can be reduced or even stopped. Although painkillers ease the symptoms of rheumatoid arthritis, they do not alter the progression of the disease or prevent joint damage. You do not need to take them if your symptoms settle with the sodium aurothiomalate injections.

• Sodium aurothiomalate can cause your skin to become discoloured if it is exposed to direct sunlight. On bright days, wear suitable clothing to cover as much of your skin as possible, and use a sunscreen with a high sun protection factor. Do not use sunbeds.

• As far as possible, try to keep active. The muscles around your joints will become weak if they are not used. Regular exercise may also help to reduce pain and improve joint function.

• Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.

• If you buy any medicines, always check with a pharmacist that they are suitable to take alongside your other medicines.

En plus de leurs effets bénéfiques, la plupart des médicaments peuvent provoquer des effets secondaires indésirables, bien que tout le monde ne les ressente pas. Ceux-ci s'améliorent généralement à mesure que votre corps s'adapte au nouveau médicament, mais parlez à votre médecin ou à votre pharmacien si l'un des effets secondaires suivants persiste ou devient gênant.

Important: your doctor will discuss with you the possibility of rare but serious unwanted side-effects from this treatment. Contact your doctor straightaway if you develop any of the following:

• A severe or blistering skin rash, or any signs of an allergic reaction.

• Feeling breathless, dry cough, chest pain.

• Stomach pains and loose, watery stools (diarrhoea), with or without blood present.

• Sore throat, a high temperature, unexplained bruising or bleeding, mouth ulcers, a metallic taste in your mouth, or if you feel generally unwell or tired.

• Any yellowing of your skin or the whites of the eyes.

• Any numbness or loss of feeling or movement, particularly in your legs.

• Difficulty concentrating on things or difficulty controlling your movements.

• Swollen ankles or weight gain.

Si vous ressentez d'autres symptômes que vous pensez être dus à ce médicament, parlez-en à votre médecin ou à votre pharmacien.

• Gardez tous les médicaments hors de la portée et de la vue des enfants.

• Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.