Surfactant dysfunction
Dernière mise à jour 18 Aug 2020
Respecte les directives éditoriales
- TéléchargerTélécharger
- Partager
- Language
- Discussion
- Version audio
- Ajouter aux sources préférées sur Google
Surfactant dysfunction is a lung disorder that causes breathing problems. This condition results from abnormalities in the composition or function of surfactant, a mixture of certain fats (called phospholipids) and proteins that lines the lung tissue and makes breathing easy. Without normal surfactant, the tissue surrounding the air sacs in the lungs (the alveoli) sticks together (because of a force called surface tension) after exhalation, causing the alveoli to collapse. As a result, filling the lungs with air on each breath becomes very difficult, and the delivery of oxygen to the body is impaired.
Description
Surfactant dysfunction is a lung disorder that causes breathing problems. This condition results from abnormalities in the composition or function of surfactant, a mixture of certain fats (called phospholipids) and proteins that lines the lung tissue and makes breathing easy. Without normal surfactant, the tissue surrounding the air sacs in the lungs (the alveoli) sticks together (because of a force called surface tension) after exhalation, causing the alveoli to collapse. As a result, filling the lungs with air on each breath becomes very difficult, and the delivery of oxygen to the body is impaired.
The signs and symptoms of surfactant dysfunction can vary in severity. The most severe form of this condition causes respiratory distress syndrome in newborns. Affected babies have extreme difficulty breathing and are unable to get enough oxygen. The lack of oxygen can damage the baby's brain and other organs. This syndrome leads to respiratory failure, and most babies with this form of the condition do not survive more than a few months.
Less severe forms of surfactant dysfunction cause gradual onset of breathing problems in children or adults. Signs and symptoms of these milder forms are abnormally rapid breathing (tachypnea); low concentrations of oxygen in the blood (hypoxemia); and an inability to grow or gain weight at the expected rate (failure to thrive).
There are several types of surfactant dysfunction, which are identified by the genetic cause of the condition. One type, called SP-B deficiency, causes respiratory distress syndrome in newborns. Other types, known as SP-C dysfunction and ABCA3 deficiency, have signs and symptoms that range from mild to severe.
Inheritance patterns
The source lists the following possible inheritance patterns: Autosomal recessive; Autosomal dominant. More than one pattern can apply in different cases.
Related genes
Other names
Interstitial lung disease due to surfactant deficiency
Pulmonary surfactant metabolism dysfunction
Surfactant metabolism deficiency
Related patient information and medicines
Patient information leaflet
Bébés prématurés
This is very common in extremel... It is due to the lungs not being developed enough to be ready to breathe in air. This is partly due to lack of a substance called surfactant, produced by the lungs, which stops the air spaces from collapsing. An artificial surfactant product can be given to the baby's lungs to help them function better. In some.
Patient information leaflet
Vieillissement
Vieillissement (also spelt aging) is the process of becoming older. This happens continually throughout life. Older age tends to bring with it unwelcome changes such as a greater risk of health problems and typical changes to appearance. As populations are living longer, the challenge is to avoid living longer in ill health, but instead to have longer.
Patient information leaflet
Acromégalie
Thickening of the nasal. This can make you have a poor night's sleep and make you drowsy during the day. You may develop carpal tunnel syndrome, which occurs when a nerve in the wrist is squeezed by thickened tissue. This can cause pain, tingling and weakness in parts of the hands or arms. Women may experience irregular or missed periods. Other.
Patient information leaflet
Perte auditive
Dans conductive tests d'audition loss, the movement of sound (conduction) is blocked or does not pass into the inner ear. This often arises due to the presence of wax or fluid in the middle ear, although it may also be caused by a burst (ruptured) eardrum or by thickening of the bones in the middle ear known as otosclerosis (see below). Sensorineural hearing.
Patient information leaflet
Yeux secs
It can occur as a result of various conditions. What is the tear film. Your tear film has three layers - the main middle watery layer, the thin outer oily layer, and the thin inner mucus layer. The main middle watery layer is what we usually think of as tears. Each eye has a lacrimal gland just above, and to the outer side, tucked right up.
Patient information leaflet
Alpha-bloquants
Alpha-bloquants sont les médicaments that are mainly used to treat high blood pressure (hypertension) and problems with passing urine in men who have enlargement of the prostate gland. Prostate gland enlargement is also called benign prostatic hyperplasia (BPH). What are alpha-blockers used for. In the past, some alpha-blockers were also used to treat.
Lectures complémentaires et références
- Surfactant dysfunction; MedlinePlus, National Library of Medicine.
- Doan ML, Guillerman RP, Dishop MK, Nogee LM, Langston C, Mallory GB, Sockrider MM, Fan LL. Clinical, radiological and pathological features of ABCA3 mutations in children. Thorax. 2008 Apr;63(4):366-73. doi: 10.1136/thx.2007.083766. Epub 2007 Nov 16.
- Gower WA, Nogee LM. Surfactant dysfunction. Paediatr Respir Rev. 2011 Dec;12(4):223-9. doi: 10.1016/j.prrv.2011.01.005. Epub 2011 Mar 5.
- Hamvas A, Cole FS, Nogee LM. Genetic disorders of surfactant proteins. Neonatology. 2007;91(4):311-7. doi: 10.1159/000101347. Epub 2007 Jun 7.
- Hamvas A. Inherited surfactant protein-B deficiency and surfactant protein-C associated disease: clinical features and evaluation. Semin Perinatol. 2006 Dec;30(6):316-26. doi: 10.1053/j.semperi.2005.11.002.
- Nkadi PO, Merritt TA, Pillers DA. An overview of pulmonary surfactant in the neonate: genetics, metabolism, and the role of surfactant in health and disease. Mol Genet Metab. 2009 Jun;97(2):95-101. doi: 10.1016/j.ymgme.2009.01.015. Epub 2009 Feb 4.
- Thouvenin G, Abou Taam R, Flamein F, Guillot L, Le Bourgeois M, Reix P, Fayon M, Counil F, Depontbriand U, Feldmann D, Pointe HD, de Blic J, Clement A, Epaud R. Characteristics of disorders associated with genetic mutations of surfactant protein C. Arch Dis Child. 2010 Jun;95(6):449-54. doi: 10.1136/adc.2009.171553. Epub 2010 Apr 19.
- Wambach JA, Casey AM, Fishman MP, Wegner DJ, Wert SE, Cole FS, Hamvas A, Nogee LM. Genotype-phenotype correlations for infants and children with ABCA3 deficiency. Am J Respir Crit Care Med. 2014 Jun 15;189(12):1538-43. doi: 10.1164/rccm.201402-0342OC.
Participez à la conversation
Partagez vos pensées ou expériences avec les autres dans notre communautés de patients.
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.
Inscrivez-vous à la newsletter Patient
Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.