Wnt family member 4
Dernière mise à jour 18 Aug 2020
Respecte les directives éditoriales
- TéléchargerTélécharger
- Partager
- Language
- Discussion
- Version audio
- Ajouter aux sources préférées sur Google
La WNT4 gene belongs to a family of WNT genes that play critical roles in development before birth. WNT genes provide instructions for making proteins that participate in chemical signaling pathways in the body. These pathways control the activity of certain genes and regulate the interactions between cells during embryonic development.
Normal function
La WNT4 gene belongs to a family of WNT genes that play critical roles in development before birth. WNT genes provide instructions for making proteins that participate in chemical signaling pathways in the body. These pathways control the activity of certain genes and regulate the interactions between cells during embryonic development.
La WNT4 gene provides instructions for producing a protein that is important for the formation of the female reproductive system, the kidneys, and several hormone-producing glands. During the development of the female reproductive system, the WNT4 protein regulates the formation of the Müllerian ducts, which are structures in the embryo that develop into the uterus, fallopian tubes, cervix, and the upper part of the vagina. This protein is also involved in development of the ovaries, from before birth through adulthood, and is important for development and maintenance of egg cells (oocytes) in the ovaries. In addition, the WNT4 protein regulates the production of male sex hormones (androgens).
Conditions referring to this gene or chromosome
Other names
wingless-type MMTV integration site family member 4
wingless-type MMTV integration site family, member 4
WNT-4
WNT-4 protein
WNT4_HUMAN
Related patient information and medicines
Patient information leaflet
Maladie de Huntington
This is known as juvenile Huntington's disease. La maladie de Huntington est causée par un gène défectueux que vous héritez de vos parents. Maladie de Huntington est an autosomal dominant condition, meaning you can inherit the disease from just one of your parents. ...hild they have will inherit the faulty geneIf a member of your family who is carrying.
Patient information leaflet
Maladie polykystique des reins
There are different types of rein polykystique disease: Autosomal dominant polycystic kidney maladie (ADPKD) This is the most common type. This is an hereditary condition caused by a faulty gene which is inherited from one parent. Non-hereditary polycystic kidney disease In about 1 in 10 people who develop polycystic kidney disease, the faulty.
Patient information leaflet
Syndrome du canal carpien
Carpal tunnel syndrome is a set of symptoms thought to be caused by squashing (compression) of the median nerve in the carpal tunnel. What is carpal tunnel syndrome. Carpal tunnel syndrome is more common in people who are obese and it often runs in families. You have an increased risk of carpal tunnel syndrome if a close family member (father,.
Patient information leaflet
Rétinoblastome
It discusses the symptoms and signs of rétinoblastome and the management options children with retinoblastoma may be offered. Retinoblastoma is a tumour which usually affects children aged under 5. See separate leaflet called Cancer - A General Overview for more general information about cancer How common est retinoblastoma. Siblings of an... See.
Patient information leaflet
Dystrophie musculaire de Duchenne
Dystrophie musculaire de Duchenne is caused by a genetic change which affects the. Muscles contain a protein called dystrophin, which is necessary for muscles to function properly. This can happen if an error occurs when the parents' genes are... About half the children with DMD will not have family members carrying the gene. DNA testing and specialised.
Patient information leaflet
Voyager vers des lieux éloignés
Remote travel is easy and accessible. However, once you get to your destination you may be in a very different enviro... In the event of serious illness or injury it could be hours or days before you can be evacuated. Before travelling, consult the Foreign and Commonwealth Office (FCO) website (see under 'Further Reading and References' below) for.
Lectures complémentaires et références
- Wnt family member 4; MedlinePlus, National Library of Medicine.
- Bernard P, Harley VR. Wnt4 action in gonadal development and sex determination. Int J Biochem Cell Biol. 2007;39(1):31-43. doi: 10.1016/j.biocel.2006.06.007. Epub 2006 Jul 5.
- Biason-Lauber A, De Filippo G, Konrad D, Scarano G, Nazzaro A, Schoenle EJ. WNT4 deficiency--a clinical phenotype distinct from the classic Mayer-Rokitansky-Kuster-Hauser syndrome: a case report. Hum Reprod. 2007 Jan;22(1):224-9. doi: 10.1093/humrep/del360. Epub 2006 Sep 7.
- Biason-Lauber A, Konrad D, Navratil F, Schoenle EJ. A WNT4 mutation associated with Mullerian-duct regression and virilization in a 46,XX woman. N Engl J Med. 2004 Aug 19;351(8):792-8. doi: 10.1056/NEJMoa040533.
- Biason-Lauber A, Konrad D. WNT4 and sex development. Sex Dev. 2008;2(4-5):210-8. doi: 10.1159/000152037. Epub 2008 Nov 5.
- Biason-Lauber A. WNT4, RSPO1, and FOXL2 in sex development. Semin Reprod Med. 2012 Oct;30(5):387-95. doi: 10.1055/s-0032-1324722. Epub 2012 Oct 8.
- Clement-Ziza M, Khen N, Gonzales J, Cretolle-Vastel C, Picard JY, Tullio-Pelet A, Besmond C, Munnich A, Lyonnet S, Nihoul-Fekete C. Exclusion of WNT4 as a major gene in Rokitansky-Kuster-Hauser anomaly. Am J Med Genet A. 2005 Aug 15;137(1):98-9. doi: 10.1002/ajmg.a.30833. No abstract available.
- Jaaskelainen M, Prunskaite-Hyyrylainen R, Naillat F, Parviainen H, Anttonen M, Heikinheimo M, Liakka A, Ola R, Vainio S, Vaskivuo TE, Tapanainen JS. WNT4 is expressed in human fetal and adult ovaries and its signaling contributes to ovarian cell survival. Mol Cell Endocrinol. 2010 Apr 12;317(1-2):106-11. doi: 10.1016/j.mce.2009.11.013. Epub 2009 Dec 3.
- Jordan BK, Mohammed M, Ching ST, Delot E, Chen XN, Dewing P, Swain A, Rao PN, Elejalde BR, Vilain E. Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans. Am J Hum Genet. 2001 May;68(5):1102-9. doi: 10.1086/320125. Epub 2001 Mar 29.
- Mandel H, Shemer R, Borochowitz ZU, Okopnik M, Knopf C, Indelman M, Drugan A, Tiosano D, Gershoni-Baruch R, Choder M, Sprecher E. SERKAL syndrome: an autosomal-recessive disorder caused by a loss-of-function mutation in WNT4. Am J Hum Genet. 2008 Jan;82(1):39-47. doi: 10.1016/j.ajhg.2007.08.005.
- Philibert P, Biason-Lauber A, Rouzier R, Pienkowski C, Paris F, Konrad D, Schoenle E, Sultan C. Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and mullerian duct abnormalities: a French collaborative study. J Clin Endocrinol Metab. 2008 Mar;93(3):895-900. doi: 10.1210/jc.2007-2023. Epub 2008 Jan 8.
- Prunskaite-Hyyrylainen R, Shan J, Railo A, Heinonen KM, Miinalainen I, Yan W, Shen B, Perreault C, Vainio SJ. Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimullerian hormone expression during oocyte maturation in the female follicle. FASEB J. 2014 Apr;28(4):1568-81. doi: 10.1096/fj.13-233247. Epub 2013 Dec 26.
Participez à la conversation
Partagez vos pensées ou expériences avec les autres dans notre communautés de patients.
Demandez, partagez, connectez-vous.
Parcourez les discussions, posez des questions et partagez vos expériences sur des centaines de sujets de santé.
Inscrivez-vous à la newsletter Patient
Votre dose hebdomadaire de conseils de santé clairs et fiables - rédigés pour vous aider à vous sentir informé, confiant et maître de la situation.
En vous abonnant, vous acceptez notre Politique de confidentialité. Vous pouvez vous désabonner à tout moment. Nous ne vendons jamais vos données.