Can I take Atorvastatin and Ramipril together?

You can safely take these medicines together as prescribed by your doctor.

Atorvastatin (a statin) and ramipril (an ACE inhibitor) work in different ways and are processed by different pathways in the body. They do not interfere with each other's absorption or metabolism.

How to take atorvastatin and ramipril safely

It is often recommended to take atorvastatin in the evening and ramipril at the same time each day (often in the morning), but follow the specific timing instructions given by your healthcare provider.

Important precautions

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Angio-oedema (swelling)

Seek emergency medical help if you experience swelling of the face, lips, tongue, or throat, as ramipril can cause a severe allergic reaction called angio-oedema.

Food and drink warnings

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

Drinking alcohol can increase the blood-pressure-lowering effect of ramipril, which may make you feel dizzy or lightheaded. For atorvastatin, regular heavy drinking increases the risk of liver problems.

Salt substitutes (low-sodium salts)

Many salt substitutes (such as LoSalt) are high in potassium. Ramipril can also increase potassium levels in your blood. Using both together can lead to dangerously high potassium levels (hyperkalaemia).

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.