Gélules de Danazol
Révision par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour le 26 novembre 2024
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Clinical author's note Michael Stewart 26/11/2024: Danol® capsules have been discontinued in the UK. At the time of review there are no licensed products containing danazol available in the UK. However danazol is available as a specially manufactured medicine or as an imported medicine. Products are still available in other countries. This medicine leaflet is based on medical information available in the UK at the time of writing and is left here for reference purposes. Please also refer to the manufacturer's information supplied with your medicine.
Start taking danazol on the first day of your period unless you have been told otherwise. You can take the capsules either before or after meals.
It is important that you do not become pregnant while on danazol. Follow your doctor's advice about suitable contraception.
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About danazol
Type de médicament | A gonadotrophin inhibitor |
Utilisé pour | Endometriosis; breast cyst pain |
Également appelé | Danol® (discontinued); Cyclomen® (in Canada) |
Disponible en | Capsules |
Danazol works by altering the levels of some of your body's hormones. It is used to treat a number of different conditions.
Endometriosis is a condition where tissue that normally lines the inside of your womb (uterus) is found elsewhere in your body, often in the pelvic area or abdomen. It can cause painful periods and persistent pain in the pelvic area, as well as other symptoms. By altering the levels of your hormones, danazol will help to relieve these symptoms.
Danazol is also prescribed to ease severe pain and tenderness associated with breast cyst disease (where other treatments have proved unhelpful). Breast cysts are small lumps which are found in the breast, but which are not cancerous.
In addition to the two conditions above, danazol is also prescribed by specialist doctors for people with a condition known as hereditary angio-oedema (although it is not licensed for this condition). If you have been prescribed it for this reason, please speak with your doctor if you have any questions about your treatment.
Before taking danazol
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking danazol it is important that your doctor knows:
Si vous êtes enceinte, si vous essayez d'avoir un enfant ou si vous allaitez.
Si vous souffrez d'une maladie cardiaque.
If you have any vaginal bleeding other than your regular period.
If you have ever had an unwanted blood clot (thrombosis), or stroke.
If you have any of the following conditions: epilepsy, diabetes (diabetes mellitus), high blood pressure, migraine, or a blood fat (lipid) disorder.
Si vous avez des problèmes de fonctionnement du foie ou des reins.
If you have either of the following blood disorders: polycythaemia or porphyria.
If you know you have a type of cancer which is affected by hormones.
Si vous prenez ou utilisez d'autres médicaments. Cela comprend tous les médicaments que vous prenez et qui sont disponibles sans ordonnance, ainsi que les médicaments à base de plantes et les médicaments complémentaires.
Si vous avez déjà eu une réaction allergique à un médicament.
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How to take danazol
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about danazol, and will also provide you with a full list of side-effects which you could experience from taking it.
You should start taking danazol on the first day of your next period unless you have been told otherwise.
Your doctor will tell you how many capsules to take each day, and when you should take them. As a guide, for the treatment of endometriosis or breast pain, danazol is usually taken 2-4 times daily for 3-6 months. Take the capsules exactly as your doctor tells you to. Your dose will be printed on the label of the pack to remind you about what the doctor said to you.
Swallow the capsules whole with a drink of water - do not chew or open them before you swallow.
You can take danazol capsules either before or after meals, but try to take your doses at the same times each day, as this will help you to remember to take them regularly.
Si vous oubliez de prendre une dose, prenez-la dès que vous vous en rendez compte (sauf s'il est presque temps de prendre la dose suivante, auquel cas ne prenez pas la dose oubliée). Ne prenez pas deux doses en même temps pour compenser une dose oubliée.
Tirer le meilleur parti de votre traitement
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor may want you to have some blood tests during this treatment.
It is important that you do not become pregnant while you are on danazol. If appropriate, you and your partner should use a non-hormonal method of contraception, such as a condom. This is because hormonal methods (such as 'the pill' or 'mini pill') will not work. Speak with your doctor if you need further advice about what methods of contraception are suitable for you to use.
It is best not to drink alcohol while you are on danazol. This is because drinking alcohol while taking danazol could make you feel sick or short of breath.
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Can danazol cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with danazol. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Danazol side-effects | Que puis-je faire si je suis confronté à cette situation ? |
Sensation de malaise (nausée), douleur à l'estomac | S'en tenir à des aliments simples (éviter les repas riches ou épicés) |
Feeling dizzy or tired, eyesight changes | If this happens, do not drive and do not use tools or machines while affected. Let your doctor know about any eyesight changes |
Maux de tête, autres douleurs | Ask your pharmacist to recommend a suitable painkiller. If the headache is severe or continues, speak with your doctor |
Increased growth of hair (particularly on your body or face), voice changes, hair loss similar to male baldness | Speak with your doctor about this as soon as possible. An alternative treatment may be more suitable for you |
Acne, skin rash, muscle cramps, mood changes, changes in your desire for sex, increased appetite and weight changes, irregular menstrual periods, vaginal dryness and irritation, hot flushes, reduced breast size, a feeling that your heart is racing | Si l'un d'entre eux devient gênant, parlez-en à votre médecin. |
Important: if you experience any of the following rare but possibly serious symptoms, please speak with your doctor straightaway:
A severe headache and sickness (nausea and vomiting).
Jaunissement de la peau ou du blanc des yeux (jaunisse).
Any painful swelling of your arms or legs, or sudden chest pain.
Any bruising that you can't explain. This could be a sign of a blood disorder.
Si vous ressentez d'autres symptômes qui pourraient être dus aux gélules, demandez conseil à votre médecin ou à votre pharmacien.
How to store danazol
Conservez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
Ne dépassez jamais la dose prescrite. Si vous pensez que vous ou quelqu'un d'autre avez pris une dose excessive de ce médicament, rendez-vous immédiatement au service des accidents et des urgences de votre hôpital local. Emportez la boîte avec vous, même si elle est vide.
Si vous achetez des médicaments, vérifiez toujours auprès d'un pharmacien qu'ils peuvent être pris avec vos autres médicaments.
If you are due to have an operation or any dental treatment, please tell the person carrying out the treatment which medicines you are taking.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas les médicaments périmés ou dont vous ne voulez plus. Apportez-les à votre pharmacie locale qui les éliminera pour vous.
Si vous avez des questions sur ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne sur le site web de la carte jaune.
Autres lectures et références
- Médicaments Complet BNF 89ème éditionBritish Medical Association et Royal Pharmaceutical Society of Great Britain, Londres.
Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
Prochaine révision prévue : 26 Nov 2027
26 Nov 2024 | Dernière version

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