Noréthistérone pour les règles douloureuses ou abondantes
Primolut N, Utovlan
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 17 Feb 2023
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Norethisterone is a female hormone treatment.
The usual dose is one tablet either two or three times daily. You may be asked to take the tablets regularly each day, or just to take them on certain days of the month.
The most common side-effects are feeling bloated, feeling sick (nausea), and headache. These are generally mild in nature.
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Sélections de vidéos pour Traitement du déséquilibre hormonal
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About norethisterone
Type de médicament | Progestogen (female hormone) |
Utilisé pour | Painful or heavy periods, particularly when associated with endometriosis |
Aussi appelé | Norethindrone (in US); Primolut N®, Utovlan® |
Disponible sous forme de | Comprimés |
Norethisterone is a man-made form of progesterone, a naturally occurring female sex hormone. It is referred to as a progestogen and it has a number of uses. Low doses are used to prevent pregnancy, or as hormone replacement therapy (HRT). Medium-strength tablets (5 mg) such as Primolut N® and Utovlan® are used to treat heavy and painful periods particularly if they are associated with a condition called endometriosis. Higher doses are used in the treatment of some female cancers, such as breast cancer.
This leaflet discusses norethisterone when it is used to treat painful or heavy periods associated with endometriosis. Endometriosis is a condition where tissue which is normally only found inside the womb (uterus), becomes 'trapped' in other parts of the body, often in the pelvic area or lower abdomen. This causes symptoms such as painful and heavy periods. Treatment aims to reduce the pain and amount of blood loss. Norethisterone can also be considered for heavy periods not associated with endometriosis, although other treatment options are more commonly prescribed for this.
There are a number of other medicine leaflets which will give you more information about norethisterone if you are taking it for contraception or as HRT. These are: Comprimés contraceptifs à base de progestogène seul, Injection contraceptive de noréthistérone, Combined hormonal contraceptives et Œstrogène et progestatif pour THS.
Before taking norethisterone
Retour au sommaireSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking norethisterone it is important that your doctor knows:
Si vous êtes enceinte ou si vous allaitez.
If you have any problems with the way your liver works, or any kidney problems.
If you have heart or blood vessel problems, or if you have ever had a blood clot in an artery or vein.
If you have any of the following: diabetes, epilepsy, migraines, high blood pressure (hypertension), or asthma.
If you smoke, are overweight or have high cholesterol levels.
If you have ever had cancer.
Si vous avez déjà eu une maladie dépressive.
If you have ever had yellowing of your skin or the whites of your eyes (jaundice), severe itching, or a skin condition called pemphigoid gestationis during a pregnancy.
Si vous avez un trouble sanguin héréditaire rare appelé porphyrie.
Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et les médecines complémentaires.
If you have ever had an allergic reaction to a medicine.
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How to take norethisterone
Retour au sommaireBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about norethisterone and will provide you with a full list of the side-effects which you may experience from taking it.
Take norethisterone exactly as your doctor tells you to. You may be asked to take the tablets regularly each day, or to take them just on certain days of your monthly cycle. This information will be printed on the label of your pack of tablets to remind you, but if you are still unsure, ask your pharmacist for further advice.
It is common to take one tablet three times each day, although your dose may be different to this.
Swallow the tablets with a drink of water. You can take norethisterone tablets either before or after meals.
Try to take your doses at the same times of day, as this will help you to remember to take your doses.
If you do forget to take a dose at your usual time, take it as soon as you remember, unless it is nearly time for your next dose in which case leave out the forgotten dose. Remember to take your next dose when it is due but do not take two doses together to make up for a forgotten dose.
Tirer le meilleur parti de votre traitement
Retour au sommaireEssayez de respecter vos rendez-vous réguliers avec votre médecin. Cela permet à votre médecin de suivre vos progrès.
You should avoid getting pregnant, as norethisterone can affect a developing baby. Use barrier methods of contraception (such as a condom) if you have sex whilst taking norethisterone. If you need further contraceptive advice, speak with your doctor.
If you have diabetes you may need to check your blood glucose more frequently, as norethisterone can affect the levels of sugar in your blood. Your doctor will be able to advise you about this.
If you are due to have an operation or any medical treatment, tell the person carrying out the treatment that you are taking norethisterone.
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Can norethisterone cause problems?
Retour au sommaireAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with norethisterone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common norethisterone side-effects | Que puis-je faire si je ressens cela ? |
Shorter periods, no periods, breakthrough bleeding, 'spotting' | Your doctor will discuss this with you before you start treatment |
Sensation de malaise (nausée) | Stick to simple meals - avoid rich and spicy foods. If you are not already doing so, try taking the tablets after a meal |
Maux de tête | Ask your pharmacist to recommend a suitable painkiller. If the headache is unusually severe or continues, speak with your doctor straightaway |
Bloating, fluid retention | Si cela pose problème, parlez-en à votre médecin |
Less common norethisterone side-effects | Que puis-je faire si je ressens cela ? |
Feeling dizzy, breast tenderness, changes in weight, feeling tired or difficulty sleeping, feeling depressed, lack of interest in sex, skin reactions | Si l'un de ces éléments devient problématique, parlez-en à votre médecin |
Important: norethisterone can also have some serious side-effects, although these occur only rarely. If you experience any of the following symptoms, stop taking the tablets and contact your doctor for advice straightaway:
Any feeling of pain or tightness in your chest.
Any disturbances of your vision or hearing.
Any unusually severe headaches.
Tout jaunissement de votre peau ou du blanc de vos yeux (jaunisse).
Si vous ressentez d'autres symptômes que vous pensez être dus aux comprimés, consultez votre médecin ou votre pharmacien pour obtenir des conseils.
How to store norethisterone
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Si vous achetez des médicaments « en vente libre », vérifiez toujours auprès d'un pharmacien qu'ils conviennent à la prise avec vos autres médicaments.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le site web Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Lectures complémentaires et références
- Manufacturer's PIL, Utovlan® tablets; Pfizer Limited, The electronic Medicines Compendium. Dated December 2018.
- Manufacturer's PIL, Primolut N®; Bayer plc, The electronic Medicines Compendium. Dated July 2021.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Next review due: 16 Aug 2027
17 Feb 2023 | Dernière version

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