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Norethisterone pour les règles douloureuses ou abondantes

Primolut N, Utovlan

Norethisterone is a female hormone treatment.

The usual dose is one tablet either two or three times daily. You may be asked to take the tablets regularly each day, or just to take them on certain days of the month.

The most common side-effects are feeling bloated, feeling sick (nausea), and headache. These are generally mild in nature.

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About norethisterone

Type de médicament

Progestogen (female hormone)

Utilisé pour

Painful or heavy periods, particularly when associated with endometriosis

Également appelé

Norethindrone (in US); Primolut N®, Utovlan®

Disponible en

Tablettes

Norethisterone is a man-made form of progesterone, a naturally occurring female sex hormone. It is referred to as a progestogen and it has a number of uses. Low doses are used to prevent pregnancy, or as hormone replacement therapy (HRT). Medium-strength tablets (5 mg) such as Primolut N® and Utovlan® are used to treat heavy and painful periods particularly if they are associated with a condition called endometriosis. Higher doses are used in the treatment of some female cancers, such as breast cancer.

This leaflet discusses norethisterone when it is used to treat painful or heavy periods associated with endometriosis. Endometriosis is a condition where tissue which is normally only found inside the womb (uterus), becomes 'trapped' in other parts of the body, often in the pelvic area or lower abdomen. This causes symptoms such as painful and heavy periods. Treatment aims to reduce the pain and amount of blood loss. Norethisterone can also be considered for heavy periods not associated with endometriosis, although other treatment options are more commonly prescribed for this.

There are a number of other medicine leaflets which will give you more information about norethisterone if you are taking it for contraception or as HRT. These are: Progestogen-only contraceptive tablets, Norethisterone contraceptive injection, Combined hormonal contraceptives and Oestrogen and progestogen for HRT.

Before taking norethisterone

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking norethisterone it is important that your doctor knows:

  • Si vous êtes enceinte ou si vous allaitez.

  • If you have any problems with the way your liver works, or any kidney problems.

  • If you have heart or blood vessel problems, or if you have ever had a blood clot in an artery or vein.

  • If you have any of the following: diabetes, epilepsy, migraines, high blood pressure (hypertension), or asthma.

  • If you smoke, are overweight or have high cholesterol levels.

  • If you have ever had cancer.

  • Si vous avez déjà souffert d'une maladie dépressive.

  • If you have ever had yellowing of your skin or the whites of your eyes (jaundice), severe itching, or a skin condition called pemphigoid gestationis during a pregnancy.

  • Si vous êtes atteint d'une maladie sanguine héréditaire rare appelée porphyrie.

  • Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles sans ordonnance, ainsi que les médicaments à base de plantes et les médicaments complémentaires.

  • Si vous avez déjà eu une réaction allergique à un médicament.

Poursuivre la lecture ci-dessous

How to take norethisterone

  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about norethisterone and will provide you with a full list of the side-effects which you may experience from taking it.

  • Take norethisterone exactly as your doctor tells you to. You may be asked to take the tablets regularly each day, or to take them just on certain days of your monthly cycle. This information will be printed on the label of your pack of tablets to remind you, but if you are still unsure, ask your pharmacist for further advice.

  • It is common to take one tablet three times each day, although your dose may be different to this.

  • Swallow the tablets with a drink of water. You can take norethisterone tablets either before or after meals.

  • Try to take your doses at the same times of day, as this will help you to remember to take your doses.

  • If you do forget to take a dose at your usual time, take it as soon as you remember, unless it is nearly time for your next dose in which case leave out the forgotten dose. Remember to take your next dose when it is due but do not take two doses together to make up for a forgotten dose.

Tirer le meilleur parti de votre traitement

  • Essayez de vous rendre à vos rendez-vous réguliers avec votre médecin. Il pourra ainsi vérifier vos progrès.

  • You should avoid getting pregnant, as norethisterone can affect a developing baby. Use barrier methods of contraception (such as a condom) if you have sex whilst taking norethisterone. If you need further contraceptive advice, speak with your doctor.

  • If you have diabetes you may need to check your blood glucose more frequently, as norethisterone can affect the levels of sugar in your blood. Your doctor will be able to advise you about this.

  • If you are due to have an operation or any medical treatment, tell the person carrying out the treatment that you are taking norethisterone.

Poursuivre la lecture ci-dessous

Can norethisterone cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with norethisterone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common norethisterone side-effects

Que puis-je faire si je suis confronté à cette situation ?

Shorter periods, no periods, breakthrough bleeding, 'spotting'

Your doctor will discuss this with you before you start treatment

Sensation de malaise (nausée)

Stick to simple meals - avoid rich and spicy foods. If you are not already doing so, try taking the tablets after a meal

Maux de tête

Ask your pharmacist to recommend a suitable painkiller. If the headache is unusually severe or continues, speak with your doctor straightaway

Bloating, fluid retention

En cas de troubles, parlez-en à votre médecin

Less common norethisterone side-effects

Que puis-je faire si je suis confronté à cette situation ?

Feeling dizzy, breast tenderness, changes in weight, feeling tired or difficulty sleeping, feeling depressed, lack of interest in sex, skin reactions

Si l'un d'entre eux devient gênant, parlez-en à votre médecin.

Important: norethisterone can also have some serious side-effects, although these occur only rarely. If you experience any of the following symptoms, stop taking the tablets and contact your doctor for advice straightaway:

  • Any feeling of pain or tightness in your chest.

  • Any disturbances of your vision or hearing.

  • Any unusually severe headaches.

  • Jaunissement de la peau ou du blanc des yeux (jaunisse).

If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for advice.

How to store norethisterone

  • Conservez tous les médicaments hors de la portée et de la vue des enfants.

  • Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.

Informations importantes sur tous les médicaments

Informations importantes sur tous les médicaments

Ne dépassez jamais la dose prescrite. Si vous pensez que vous ou quelqu'un d'autre avez pris une dose excessive de ce médicament, rendez-vous au service des accidents et des urgences de votre hôpital local. Emportez la boîte avec vous, même si elle est vide.

Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.

Si vous achetez des médicaments en vente libre, vérifiez toujours auprès d'un pharmacien qu'ils peuvent être pris avec vos autres médicaments.

Ne gardez pas les médicaments périmés ou dont vous ne voulez plus. Apportez-les à votre pharmacie locale qui les éliminera pour vous.

Si vous avez des questions sur ce médicament, demandez à votre pharmacien.

Signaler les effets secondaires d'un médicament ou d'un vaccin

Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne sur le site web de la carte jaune.

Autres lectures et références

Historique de l'article

Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.

  • Prochaine révision prévue : 16 février 2026
  • 17 Feb 2023 | Dernière version

    Dernière mise à jour par

    Michael Stewart, MRPharmS

    Examiné par des pairs

    Sid Dajani
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