Crème de Doxépine
Xepin
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSLast updated 19 janv. 2025
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Doxepin cream helps to reduce itching associated with eczema.
Apply a thin layer of cream three or four times a day.
It can make you feel sleepy. If this happens, do not drive and do not use tools or machines.
At a glance
Doxepin cream is an antipruritic cream used to reduce itching from eczema in adults and children over 12.
Apply a thin layer to itchy areas three or four times daily, not exceeding 12g per day.
It can cause sleepiness or dizziness; do not drive or operate machinery if affected.
Avoid alcohol as it can worsen sleepiness.
Do not cover treated skin with dressings unless advised by your doctor, as this can increase side effects.
If you experience a rash, stop using the cream and consult your doctor.
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About doxepin cream
Type de médicament | An antipruritic cream |
Utilisé pour | Itching due to eczema (in adults and in children over 12 years of age) |
Aussi appelé | Xepin® |
Disponible sous forme de | Crème |
Eczéma is sometimes called dermatitis, which means inflammation of the skin. If you have eczema, areas of your skin become dry, red and inflamed. These areas of inflamed skin are often itchy, making you want to scratch. Then when you scratch, your skin becomes even more inflamed.
Doxepin cream helps to reduce itching in people with eczema. It does this by blocking the action of a substance in your body, called histamine.
Before using doxepin cream
Retour au sommaireTo make sure this is the right treatment for you, before you start using doxepin cream it is important that your doctor knows:
Si vous êtes enceinte ou si vous allaitez.
If you have a heart condition or an irregular heart rhythm.
If you have increased pressure in your eye, a condition called glaucoma.
If you have any difficulties passing urine.
Si vous avez des problèmes avec le fonctionnement de votre foie.
If you have a mood disorder called mania.
Si vous avez déjà eu une réaction allergique à un médicament.
Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.
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How to use doxepin cream
Retour au sommaireBefore you start using the cream, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about doxepin cream, and it will also provide you with a full list of side-effects which you could experience from using it.
Apply a thin layer of doxepin cream to the itchy areas three or four times each day. It is recommended that you do not use more than 3 g of cream at any time, or more than 12 g of cream a day. As a rough guide, this means that you should never use so much that a 30 g tube of cream lasts less than three days.
Tirer le meilleur parti de votre traitement
Retour au sommaireDoxepin cream may make you feel sleepy, especially when you first start using it. If it happens to you, do not drive and do not use tools or machines while you are affected. If it continues to be a problem, apply less cream or, for a few days, reduce the number of times you apply it. You should not drink alcohol while you are using the cream as this can make the sleepiness worse.
If the treated areas of your skin are covered (either with your clothing or a dressing), this can increase how much doxepin your skin absorbs and the risk of side-effects. Do not apply more of the cream than your doctor has told you to, and do not use any dressings over the cream unless your doctor has said to do so.
Continue to use your emollients every day as this will also help to prevent your skin from becoming dry and itchy. Try to avoid extremes of temperature by wrapping up well in cold weather. Also, avoid wearing rough or irritating clothing which can make your itching worse.
If you buy any medicines, check with a pharmacist that they are suitable for you to take while you are using doxepin.
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Can doxepin cream cause problems?
Retour au sommaireAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with doxepin cream. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any continue or become troublesome.
Very common doxepin cream side-effects (these affect more than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
Se sentir somnolent ou étourdi | If this happens, do not drive and do not use tools or machines. Do not drink alcohol. Try applying smaller amounts of cream or using it less often |
Less common doxepin cream side-effects | Que puis-je faire si je ressens cela ? |
Burning, stinging or tingling of your skin | This should soon pass but you can try using less cream for a few days |
Éruption cutanée | This could be an allergic type of reaction. Stop using the cream and see your doctor for further advice |
If you experience any other symptoms which you think may be due to the cream, speak with your doctor or pharmacist for further advice.
How to store doxepin cream
Retour au sommaireGardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Retour au sommaireInformations importantes sur tous les médicaments
This cream is for use on the skin only. If someone swallows some of it, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
Si vous subissez une opération ou un traitement dentaire, informez la personne effectuant le traitement des médicaments que vous prenez ou utilisez.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Yellow Card website.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
Can doxepin cream be used for itching not caused by eczema?
Doxepin cream is specifically used for itching that is due to eczema. The article does not mention its use for other types of itching.
What should I do if I am already taking other medications?
It is important to inform your doctor about all other medicines you are taking or using, including non-prescription, herbal, and complementary medicines, before starting doxepin cream. This is to ensure it is the right treatment for you and to check for potential interactions.
Can children under 12 use doxepin cream?
Doxepin cream is indicated for use in adults and children over 12 years of age for itching due to eczema.
How long should I use doxepin cream for?
The article does not specify a duration of use. It advises applying a thin layer of cream to itchy areas three or four times daily, and to speak with your doctor or pharmacist if any side-effects continue or become troublesome.
Is it safe to cover the skin after applying doxepin cream?
You should not use dressings or cover treated areas of your skin with clothing unless your doctor has specifically told you to do so. Covering the skin can increase the amount of doxepin absorbed and may increase the risk of side-effects.
What is the maximum amount of doxepin cream I can use daily?
You should not use more than 3 g of cream at any one time, or more than 12 g of cream in a day. As a general guide, a 30 g tube of cream should last at least three days.
What should I do if I experience a rash after using the cream?
If you develop a rash, it could be an allergic reaction. You should stop using the cream immediately and consult your doctor for further advice.
Lectures complémentaires et références
- Manufacturer's PIL, Xepin® 5% cream; Cambridge Healthcare Supplies ltd. Medicines and Healthcare products Regulatory Agency (MHRA). Dated March 2015.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Prochaine révision prévue : 19 janv. 2028
19 janv. 2025 | Dernière version

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