Crème de Doxépine
Xepin
Revu par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour 19 janv. 2025
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Doxepin cream helps to reduce itching associated with eczema.
Apply a thin layer of cream three or four times a day.
It can make you feel sleepy. If this happens, do not drive and do not use tools or machines.
En un coup d'œil
Doxepin cream is an antipruritic cream for adults and children over 12.
It helps reduce itching from eczema by blocking histamine.
Apply a thin layer to itchy areas three or four times daily, up to 12g per day.
It can cause sleepiness; avoid driving or using machinery if affected.
Do not drink alcohol or use dressings over the cream unless advised by your doctor.
Tell your doctor if you have a heart condition, glaucoma, or liver problems before using it.
If skin irritation occurs, stop using the cream and see your doctor.
About doxepin cream
Type de médicament | An antipruritic cream |
Utilisé pour | Itching due to eczema (in adults and in children over 12 years of age) |
Aussi appelé | Xepin® |
Disponible sous forme de | Crème |
Eczéma is sometimes called dermatitis, which means inflammation of the skin. If you have eczema, areas of your skin become dry, red and inflamed. These areas of inflamed skin are often itchy, making you want to scratch. Then when you scratch, your skin becomes even more inflamed.
Doxepin cream helps to reduce itching in people with eczema. It does this by blocking the action of a substance in your body, called histamine.
Before using doxepin cream
To make sure this is the right treatment for you, before you start using doxepin cream it is important that your doctor knows:
Si vous êtes enceinte ou si vous allaitez.
If you have a heart condition or an irregular heart rhythm.
If you have increased pressure in your eye, a condition called glaucoma.
If you have any difficulties passing urine.
Si vous avez des problèmes avec le fonctionnement de votre foie.
If you have a mood disorder called mania.
Si vous avez déjà eu une réaction allergique à un médicament.
Si vous prenez ou utilisez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles à l'achat sans ordonnance, ainsi que les médicaments à base de plantes et complémentaires.
How to use doxepin cream
Before you start using the cream, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about doxepin cream, and it will also provide you with a full list of side-effects which you could experience from using it.
Apply a thin layer of doxepin cream to the itchy areas three or four times each day. It is recommended that you do not use more than 3 g of cream at any time, or more than 12 g of cream a day. As a rough guide, this means that you should never use so much that a 30 g tube of cream lasts less than three days.
Tirer le meilleur parti de votre traitement
Doxepin cream may make you feel sleepy, especially when you first start using it. If it happens to you, do not drive and do not use tools or machines while you are affected. If it continues to be a problem, apply less cream or, for a few days, reduce the number of times you apply it. You should not drink alcohol while you are using the cream as this can make the sleepiness worse.
If the treated areas of your skin are covered (either with your clothing or a dressing), this can increase how much doxepin your skin absorbs and the risk of side-effects. Do not apply more of the cream than your doctor has told you to, and do not use any dressings over the cream unless your doctor has said to do so.
Continue to use your emollients every day as this will also help to prevent your skin from becoming dry and itchy. Try to avoid extremes of temperature by wrapping up well in cold weather. Also, avoid wearing rough or irritating clothing which can make your itching worse.
If you buy any medicines, check with a pharmacist that they are suitable for you to take while you are using doxepin.
Can doxepin cream cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with doxepin cream. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any continue or become troublesome.
Very common doxepin cream side-effects (these affect more than 1 in 10 people) | Que puis-je faire si je ressens cela ? |
Se sentir somnolent ou étourdi | If this happens, do not drive and do not use tools or machines. Do not drink alcohol. Try applying smaller amounts of cream or using it less often |
Less common doxepin cream side-effects | Que puis-je faire si je ressens cela ? |
Burning, stinging or tingling of your skin | This should soon pass but you can try using less cream for a few days |
Éruption cutanée | This could be an allergic type of reaction. Stop using the cream and see your doctor for further advice |
If you experience any other symptoms which you think may be due to the cream, speak with your doctor or pharmacist for further advice.
How to store doxepin cream
Gardez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
This cream is for use on the skin only. If someone swallows some of it, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
Si vous subissez une opération ou un traitement dentaire, informez la personne effectuant le traitement des médicaments que vous prenez ou utilisez.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.
Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Site web de Yellow Card.

Vous n'êtes pas sûr de mélanger des médicaments ?
Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.
Questions fréquemment posées
What is the maximum duration I can use doxepin cream?
The article provides guidelines for the amount of doxepin cream to use per application and per day (no more than 3g at any time, or 12g per day, lasting at least three days for a 30g tube). However, it does not specify a maximum duration for treatment. For questions about how long to use the cream, it's best to consult your doctor or pharmacist.
Will doxepin cream interact with my other skincare products or moisturisers?
The article mentions continuing to use emollients daily to prevent dry and itchy skin while using doxepin cream. However, it does not specifically discuss interactions with other skincare products. It advises checking with a pharmacist about any other medicines you buy, which would include over-the-counter skincare, to ensure they are suitable for use with doxepin.
What should I do if I accidentally get doxepin cream in my eyes or mouth?
The article states that the cream is for use on the skin only. It advises going to accident and emergency if someone swallows some of it. For accidental contact with eyes or mouth, although not explicitly stated, it would be prudent to rinse the affected area thoroughly and seek further advice from your doctor or pharmacist if irritation persists, given the cream's active ingredients and warnings about side effects.
Can children under 12 years old use doxepin cream for eczema?
Doxepin cream is indicated for itching due to eczema in adults and in children over 12 years of age. This means it is not recommended for children under 12.
Will doxepin cream stain my clothes or bedding?
The article does not contain information about whether doxepin cream will stain clothing or bedding. When using topical creams, it's often a good practice to allow the cream to absorb before dressing or coming into contact with fabrics, but specific staining properties for doxepin cream are not mentioned.
What should I do if my itching does not improve after using doxepin cream?
The article does not explicitly state what to do if the itching does not improve. It does mention speaking with your doctor or pharmacist if any side effects continue or become troublesome, or if you experience any other symptoms you think may be due to the cream. If the cream isn't providing the intended relief for your itching, it would be appropriate to consult your doctor or pharmacist for further advice, as the treatment might need to be re-evaluated.
Lectures complémentaires et références
- Manufacturer's PIL, Xepin® 5% cream; Cambridge Healthcare Supplies ltd. Medicines and Healthcare products Regulatory Agency (MHRA). Dated March 2015.
- Médicaments Complets BNF 89e Édition; Association Médicale Britannique et Société Royale Pharmaceutique de Grande-Bretagne, Londres.
À propos de l'auteurVoir la biographie complète

Michael Stewart, MRPharmS
Responsable de l'examen des notices de médicaments – Contractuel, Pharmacien
BPharm (Hons), MRPharmS
Michael est un pharmacien communautaire exerçant dans les Midlands et le South Yorkshire avec plus de 20 ans d'expérience dans le conseil sur les médicaments et les conditions médicales. Il possède une solide expérience en formation dans le domaine de la santé, ayant produit et dispensé des cours de formation pour les équipes de pharmacie et le personnel des établissements de soins résidentiels, y compris les infirmières. Il a également contribué aux comités consultatifs de pharmacie pour la gestion des affections de faible gravité dans la communauté.
À propos du critique

Sid Dajani
Sultan Dajani a obtenu son diplôme à la London School of Pharmacy en 1994 et est devenu le plus jeune membre élu du conseil de la Royal Pharmaceutical Society depuis sa fondation en 1842.
Historique de l'article
Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.
Article également disponible en Anglais, Allemand, Espagnol, Français, Italien, Portugais, Hindi, Hébreu, Arabe, and Suédois.
Prochaine révision prévue : 19 janv. 2028
19 janv. 2025 | Dernière version

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