Etravirine pour le VIH

About etravirine

Etravirine is an antiretroviral medicine. It is used for human immunodeficiency virus (HIV) infection. It slows the progress of HIV infection, but it is not a cure. HIV destroys cells in the body, called CD4 T cells. These cells are a type of white blood cell and are important because they are involved in protecting your body from infection. If left untreated, the HIV infection weakens your immune system so that your body cannot defend itself against bacteria, viruses and other germs. Etravirine slows down the progress of HIV infection by reducing the amount of virus in your body. It does this by stopping the virus from copying (replicating) itself.

Etravirine will be prescribed for you by a doctor who is a specialist. It belongs to a group of antiretroviral medicines known as non-nucleoside reverse transcriptase inhibitors. It is given alongside a number of other antiretroviral medicines, as part of a combination therapy. Taking three or more antiretroviral medicines at the same time is more effective than taking one alone. Taking a combination of different medicines also reduces the risk that the virus will become resistant to any individual medicine. It is vital to take them exactly as prescribed to maintain success and to help to prevent the virus from becoming resistant to the medicines. These medicines are usually taken for life.

Before taking etravirine

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking etravirine it is important that your doctor knows:

• Si vous êtes enceinte ou si vous allaitez.

• Si vous avez des problèmes de fonctionnement du foie.

• Si vous êtes atteint d'une maladie sanguine héréditaire rare appelée porphyrie.

• Si vous prenez d'autres médicaments. Cela inclut tous les médicaments disponibles sans ordonnance, ainsi que les médicaments à base de plantes et les médicaments complémentaires.

• Si vous avez déjà eu une réaction allergique à un médicament.

How to take etravirine

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about etravirine, and it will also provide you with a full list of the side-effects which you could experience from taking it.

• Take etravirine exactly as your doctor tells you to. There are three strengths of tablet available: 200 mg for adults, and 25 mg and 100 mg for older children. The usual adult dose is one 200 mg tablet twice daily. If your child has been prescribed etravirine, your doctor will tell you what dose should be taken. Where possible the two daily doses should be taken 12 hours apart - so, the first dose in the morning and the other in the evening. It is important that etravirine tablets are taken following a meal or after a snack, as this will help your body to absorb the medicine.

• If you have difficulty swallowing tablets, you can mix the tablet into water, providing you then swallow the mixture straightaway.

• If you forget to take a dose, take it as soon as you remember, providing it is within six hours of the time you should have taken it. If it is more than six hours since you should have taken it, leave out the missed dose but remember to take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.

Tirer le meilleur parti de votre traitement

• Respectez vos rendez-vous réguliers avec votre médecin afin qu'il puisse suivre votre évolution. Vous devrez subir des analyses de sang régulières.

• It is important that you continue to take etravirine and your other antiretroviral treatment regularly. This will help to prevent the HIV from becoming resistant to the medicines you are taking. Even if you miss only a small number of doses, the virus can become resistant to treatment.

• If you develop an infection soon after you start the treatment, let your doctor know. As a result of taking etravirine, your immune system may start fighting an infection which was present before you started the treatment, but which you may not have been aware of.

• Suivez attentivement les conseils de votre médecin concernant les changements à apporter à votre mode de vie afin de réduire le risque de dommages à votre cœur et à vos vaisseaux sanguins. Il peut s'agir d'arrêter de fumer, de manger sainement et de faire régulièrement de l'exercice.

• Bien que le traitement par des médicaments antirétroviraux puisse réduire le risque que vous transmettiez le VIH à d'autres personnes par contact sexuel, il ne l'empêche pas. Il est important que vous utilisiez des préservatifs.

• Il n'est pas rare que les personnes séropositives se sentent déprimées, surtout peu de temps après le diagnostic et le début du traitement. Si vous vous sentez déprimé ou si vous avez l'impression de vous faire du mal, parlez-en immédiatement à votre médecin.

• Certaines personnes ayant pris des médicaments antirétroviraux (en particulier sur une longue période) ont développé une maladie appelée ostéonécrose. Il s'agit d'une maladie osseuse dans laquelle le tissu osseux meurt en raison d'une diminution de l'apport sanguin. Elle entraîne des douleurs et des raideurs articulaires et peut provoquer des difficultés de mouvement. Si vous remarquez l'un de ces symptômes, parlez-en à votre médecin.

• If you buy any medicines, supplements or herbal remedies 'over the counter', check with a pharmacist that they are suitable to take with etravirine and your other medicines. This is because some medicines interfere with antiretrovirals and can stop them from working properly.

• Certaines personnes prenant des médicaments antirétroviraux développent des changements dans la façon dont la graisse corporelle est répartie dans le corps. Cela peut entraîner des modifications de l'image corporelle. Votre médecin discutera avec vous de cette possibilité.

• Si vous devez subir une opération ou un traitement dentaire, indiquez à la personne chargée du traitement les médicaments que vous prenez.

• Treatment for HIV is usually lifelong. Continue to take etravirine regularly, even if you feel well. This is to keep your immune system healthy.

Can etravirine cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with etravirine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Si vous ressentez d'autres symptômes qui pourraient être dus aux comprimés, demandez conseil à votre médecin ou à votre pharmacien.

How to store etravirine

• Conservez tous les médicaments hors de la portée et de la vue des enfants.

• Store in a cool, dry place, away from direct heat and light. The bottle contains a desiccant to keep the tablets dry - do not transfer the tablets into any other container.

Informations importantes sur tous les médicaments