dual specificity tyrosine phosphorylation regulated kinase 1A
Dernière mise à jour 10 Apr 2023
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La DYRK1A gene provides instructions for making an enzyme that is important in the development of the nervous system. The DYRK1A enzyme is a kinase, which means that it adds a cluster of oxygen and phosphorus atoms (a phosphate group) to other proteins through a process called phosphorylation. Phosphorylation of proteins helps to control (regulate) their activity.
Normal function
La DYRK1A gene provides instructions for making an enzyme that is important in the development of the nervous system. The DYRK1A enzyme is a kinase, which means that it adds a cluster of oxygen and phosphorus atoms (a phosphate group) to other proteins through a process called phosphorylation. Phosphorylation of proteins helps to control (regulate) their activity.
The proteins whose activity the DYRK1A enzyme helps regulate are involved in various processes in cells, including cell growth and division (proliferation) and the process by which cells mature to carry out specific functions (differentiation). In nerve cells (neurons), the DYRK1A enzyme is involved in the formation and maturation of dendritic spines from dendrites. Dendrites are specialized extensions from neurons that are essential for the transmission of nerve impulses. Dendritic spines are small outgrowths from dendrites that further help transmit nerve impulses and increase communication between neurons.
Conditions referring to this gene or chromosome
Other names
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
dual specificity YAK1-related kinase
DYRK
DYRK1
HP86
MNB
mnb protein kinase homolog hp86
MNB/DYRK protein kinase
MNBH
MRD7
protein kinase minibrain homolog
serine/threonine kinase MNB
serine/threonine-specific protein kinase
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Lectures complémentaires et références
- dual specificity tyrosine phosphorylation regulated kinase 1A; MedlinePlus, National Library of Medicine.
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