Co-trimoxazole pour l'infection
Révision par Sid DajaniDernière mise à jour par Michael Stewart, MRPharmSDernière mise à jour le 19 septembre 2023
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Co-trimoxazole is a combination antibiotic. It can be taken by people who are allergic to penicillin, but it is not suitable for people who are allergic to sulfonamides.
Space out your doses evenly throughout the day, and remember to finish the course of treatment.
The most common side-effects are feeling sick, diarrhoea and headache. If you develop a skin rash or any allergic-type reaction, let your doctor know straightaway.
Dans cet article :
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About co-trimoxazole
Type de médicament | Un médicament antibactérien |
Utilisé pour | To treat or prevent certain infections |
Disponible en | Tablet, oral liquid medicine and injection |
Co-trimoxazole is a combination of two antibacterial medicines - a sulfonamide medicine called sulfamethoxazole, and trimethoprim. Although it has been prescribed widely for a range of infections in the past, it has very occasionally been associated with some serious side-effects. As a result, other antibiotics are now preferred to treat simple infections and co-trimoxazole is usually reserved for the treatment of more serious infections. In particular, it is prescribed for infections which can occur in people who have a problem with their immune systems. It works by killing the germs (bacteria) responsible for causing the infection.
Before taking co-trimoxazole
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking co-trimoxazole it is important that your doctor knows:
Si vous êtes enceinte, si vous essayez d'avoir un enfant ou si vous allaitez.
Si vous avez des problèmes de fonctionnement du foie ou des reins.
Si vous souffrez d'asthme.
If you have a blood disorder. It is particularly important that you tell your doctor if you have a rare inherited blood disorder called porphyria.
If you have an enzyme deficiency called G6PD deficiency.
If you have been told you have low amounts of the vitamin folic acid.
Si vous prenez d'autres médicaments. Cela inclut tous les médicaments que vous prenez et qui sont disponibles sans ordonnance, ainsi que les médicaments à base de plantes et les médicaments complémentaires.
If you have ever had an allergic reaction to a medicine. It is particularly important that you tell your doctor if you have ever had a bad reaction to a sulfonamide antibiotic.
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How to take co-trimoxazole
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about co-trimoxazole and will provide you with a full list of the side-effects which you may experience from taking it.
Take co-trimoxazole exactly as your doctor tells you to. Your dose will depend upon whether you are being treated because you have an infection, or to prevent an infection. As a guide, it is usual to take two doses of co-trimoxazole daily (12 hours apart) to treat an infection, but make sure you read the directions on the label, as your dose may be different to this. If co-trimoxazole has been prescribed for your child, it is likely that you will be supplied a liquid medicine - the dose will depend upon the age of the child. Read the directions on the label carefully and make sure you measure out the correct dose.
Remember to take co-trimoxazole regularly so that you keep a steady level of the medicine in your body. Try to avoid missing any doses.
Co-trimoxazole is best taken with food or a drink.
If you forget to take a dose, take it as soon as you remember. If it is almost time to take your next dose when you remember, skip the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
Tirer le meilleur parti de votre traitement
Try to drink several glasses of water each day while you are on co-trimoxazole. It is important that you do not become lacking in fluid in the body (dehydrated).
Most people improve within a few days of starting treatment. If your symptoms do not improve despite taking co-trimoxazole, go back to see your doctor, as you may need an alternative antibiotic. This is because some bacteria are resistant to some types of antibiotics.
Even if you feel your infection has cleared up, keep taking the antibiotic until the course is finished (unless your doctor tells you otherwise). This is to prevent the infection from coming back and being more difficult to treat. A typical course of treatment will last for 5-7 days, although the treatment of some of the more serious infections can take longer than this.
Some people develop thrush (a yeast infection which causes redness and itchiness in the mouth or vagina) after taking a course of antibiotics. If you think you have thrush speak to your doctor or pharmacist for advice.
Si vous devez subir une opération ou un traitement dentaire, indiquez à la personne chargée du traitement les médicaments que vous prenez.
If you buy any medicines, check with a pharmacist that they are suitable to take with co-trimoxazole.
This medicine may stop the oral typhoid vaccine from working. If you are due to have any vaccinations, make sure the person treating you knows that you are taking it.
If you still feel unwell after completing your course of the antibiotic, make another appointment to see your doctor.
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Can co-trimoxazole cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with co-trimoxazole. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Communs co-trimoxazole side-effects | Que puis-je faire si je suis confronté à cette situation ? |
Sensation de malaise (nausée) | S'en tenir à des aliments simples - éviter les aliments riches ou épicés |
Diarrhée | Boire beaucoup d'eau pour remplacer les liquides perdus. |
Maux de tête | Buvez beaucoup d'eau et demandez à votre pharmacien de vous recommander un analgésique adapté. Si les maux de tête persistent, prévenez votre médecin |
Éruption cutanée | Contact your doctor for advice tout de suite . Do not take any more doses until you have spoken with a doctor |
Si vous ressentez d'autres symptômes qui pourraient être dus au médicament, demandez conseil à votre médecin ou à votre pharmacien.
How to store co-trimoxazole
Conservez tous les médicaments hors de la portée et de la vue des enfants.
Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.
Informations importantes sur tous les médicaments
Informations importantes sur tous les médicaments
Ne dépassez jamais la dose prescrite. Si vous pensez que vous ou quelqu'un d'autre avez pris une dose excessive de ce médicament, rendez-vous au service des accidents et des urgences de votre hôpital local. Emportez la boîte avec vous, même si elle est vide.
Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.
Ne gardez pas les médicaments périmés ou dont vous ne voulez plus. Apportez-les à votre pharmacie locale qui les éliminera pour vous.
Si vous avez des questions sur ce médicament, demandez à votre pharmacien.
Signaler les effets secondaires d'un médicament ou d'un vaccin
Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne sur le site web de la carte jaune.
Autres lectures et références
- Manufacturer's PIL, Co-Trimoxazole Tablets 80/400 mg; Aspen, The electronic Medicines Compendium. Dated July 2021.
- Médicaments Complet BNF 89ème éditionBritish Medical Association et Royal Pharmaceutical Society of Great Britain, Londres.
Historique de l'article
Les informations contenues dans cette page sont rédigées et évaluées par des cliniciens qualifiés.
Prochaine révision prévue : 18 septembre 2026
19 Sept 2023 | Dernière version

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