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Sachets de colestyramine

Questran

Mix the powder from each sachet with at least 150 ml of liquid. You can mix it with water, skimmed milk, thin soup, fruit juice or puréed fruit.

Avoid taking any other medicines at the same time as colestyramine. Either take your other medicines one hour before colestyramine, or wait until 4-6 hours afterwards.

The most common side-effect is constipation.

At a glance

  • Colestyramine is a powder that helps lower cholesterol, reduce itching, or ease diarrhoea.

  • It is a bile acid sequestrant, which means it binds to bile acids in your digestive system.

  • Mix the powder from each sachet into at least 150 ml of liquid before taking it.

  • Take other medicines at least one hour before or 4-6 hours after colestyramine.

  • Common side-effects include constipation and an upset stomach.

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About colestyramine

Type de médicament

A bile acid sequestrant (binder)

Utilisé pour

Lowering cholesterol; itching caused by damage to the bile ducts; diarrhoea

Aussi appelé

Cholestyramine (in US); Questran®; Questran® Light

Disponible sous forme de

Sachets of powder

Colestyramine is a powder which works in the body as a bile acid sequestrant. This means that it binds to bile acids in your digestive system. It prevents bile acids from being reabsorbed (recycled) into your body, and this action can be useful in a number of different conditions.

You may be prescribed colestyramine sachets to help lower the amount of cholestérol in your blood, or to reduce itching caused by a problem in your bile ducts (such as primary biliary cirrhosis), or to help reduce diarrhée caused by certain medical conditions or treatments.

When it is prescribed to lower cholesterol, by preventing the bile acids from being reabsorbed, your liver has to make more bile acids, which it does by using cholesterol from your blood. This lowers the amount of cholesterol in your blood and reduces your risk of blood vessel disease.

When colestyramine is prescribed for itching or diarrhoea, it helps to control your symptoms by reducing the amount of bile acids in your blood.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking colestyramine it is important that your doctor knows:

  • Si vous êtes enceinte, essayez d'avoir un bébé ou allaitez.

  • If you are taking other medicines, including those available to buy without a prescription, as well as herbal and complementary medicines.

  • Si vous avez déjà eu une réaction allergique à un médicament.

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  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about colestyramine and will provide you with a full list of the side-effects which you may experience from taking it.

  • Take the sachets exactly as your doctor tells you to. It is usual to be prescribed one or two sachets to take each day to begin with. Depending upon your symptoms, your doctor may slowly increase the number of sachets until you are taking 3-6 sachets daily. The maximum dose is nine sachets daily. You may need to take all your sachets as one dose or as separate doses up to four times a day.

  • The powder from each sachet should be added to at least 150 ml of water. Allow the mixture to stand for 1-2 minutes, and then stir it well. If you prefer, you can also mix colestyramine with skimmed milk, soup, fruit juice or fruit smoothies. Do not take the powder without mixing it into some liquid first.

  • If you forget to take a dose, take it as soon as you remember. Try to take the correct number of sachets each day.

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. You may need to have blood tests from time to time.

  • Avoid taking any other medicines at the same time as you take colestyramine because it can stop the other medicines from being absorbed by your body. Either take your other medicines at least an hour before you take colestyramine, or wait until 4-6 hours after taking colestyramine before you take the other medicines. If you have any problems planning when to take your medicines, speak with your doctor or pharmacist for advice.

  • Treatment with colestyramine is often long-term. Continue to take it unless you are advised otherwise.

  • Taking colestyramine over a period of time may reduce your body's absorption of fat-soluble vitamins (vitamins A, D and K) and folic acid. Your doctor may advise you to take a supplement containing these vitamins.

  • If you have been prescribed colestyramine to lower cholesterol, your doctor may give you advice about lifestyle changes that could help you get the most out of your treatment. This may include reducing the amount of salt in your diet, stopping smoking, losing weight, reducing the amount of alcohol you drink, and taking regular exercise. Following this advice will help you to reduce your risk of developing heart and blood vessel disease in the future.

  • Si vous subissez une opération ou un traitement dentaire, informez la personne qui effectue le traitement des médicaments que vous prenez.

  • If you buy any medicines 'over-the-counter', check with a pharmacist that they are suitable for you to take.

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Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with colestyramine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common

colestyramine side-effects

Que puis-je faire si je ressens cela ?

Constipation

Try to eat a well-balanced diet and drink several glasses of water each day. If it becomes troublesome, speak with your doctor

Upset stomach

Optez pour des repas simples - évitez les aliments riches ou épicés

Si vous ressentez d'autres symptômes que vous pensez être dus au médicament, parlez-en à votre médecin ou à votre pharmacien pour obtenir des conseils supplémentaires.

  • Gardez tous les médicaments hors de la portée et de la vue des enfants.

  • Conserver dans un endroit frais et sec, à l'abri de la chaleur et de la lumière directes.

Informations importantes sur tous les médicaments

Ne prenez jamais plus que la dose prescrite. Si vous soupçonnez que vous ou quelqu'un d'autre avez pris une surdose de ce médicament, rendez-vous au service des urgences de votre hôpital local. Emportez le contenant avec vous, même s'il est vide.

Ce médicament est pour vous. Ne le donnez jamais à d'autres personnes, même si leur état semble être le même que le vôtre.

Ne gardez pas de médicaments périmés ou indésirables. Apportez-les à votre pharmacie locale qui s'en débarrassera pour vous.

Si vous avez des questions concernant ce médicament, demandez à votre pharmacien.

Signaler les effets secondaires d'un médicament ou d'un vaccin

Si vous ressentez des effets secondaires, vous pouvez les signaler en ligne via le Yellow Card website.

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Vérifiez les interactions possibles entre les médicaments, les compléments et les aliments avant de les prendre ensemble.

Questions fréquemment posées

What is colestyramine and how does it generally work in the body?

Colestyramine is a powder that acts as a bile acid sequestrant. It works by binding to bile acids in your digestive system, preventing them from being reabsorbed and recycled into your body. This action is useful for various conditions.

How does colestyramine help to reduce cholesterol levels?

When colestyramine prevents bile acids from being reabsorbed, your liver needs to produce more bile acids. It does this by using cholesterol from your blood, which effectively lowers your blood cholesterol levels and reduces your risk of blood vessel disease.

Can colestyramine help with itching and diarrhoea?

Yes, colestyramine can help manage itching caused by bile duct problems (like primary biliary cirrhosis) and diarrhoea resulting from certain medical conditions or treatments. It does this by reducing the amount of bile acids in your blood, which helps control these symptoms.

Is there anything I need to know about taking colestyramine if I am pregnant or breastfeeding?

If you are pregnant, trying for a baby, or breastfeeding, it's important to inform your doctor before starting colestyramine. They will assess if it's suitable for you.

What should I mix the colestyramine powder with before taking it?

You should add the powder from each sachet to at least 150 ml of water, allow it to stand for 1-2 minutes, then stir it well. You can also mix it with skimmed milk, soup, fruit juice, or fruit smoothies if you prefer. Do not take the powder without mixing it into liquid first.

How long will I need to take colestyramine?

Treatment with colestyramine is often long-term. You should continue to take it unless your doctor advises you otherwise.

Are there any nutrients I might become deficient in while taking colestyramine?

Taking colestyramine over time may reduce your body's absorption of fat-soluble vitamins (vitamins A, D, and K) and folic acid. Your doctor might recommend a supplement containing these vitamins.

Lectures complémentaires et références

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About the authorView full bio

Author image

Michael Stewart, MRPharmS

Medicine Leaflet Review Manager – Contractor, Pharmacist

BPharm (Hons), MRPharmS

Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.

About the reviewer

Author image

Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

Historique de l'article

Les informations sur cette page sont rédigées et examinées par des cliniciens qualifiés.

  • Prochaine révision prévue : 29 août 2026
  • 30 août 2023 | Dernière version

    Dernière mise à jour par

    Michael Stewart, MRPharmS

    Revu par

    Sid Dajani
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